Incidental Mutation 'IGL03127:Ptger2'
ID410201
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ptger2
Ensembl Gene ENSMUSG00000037759
Gene Nameprostaglandin E receptor 2 (subtype EP2)
SynonymsEP2 receptor, Ptgerep2, EP2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03127
Quality Score
Status
Chromosome14
Chromosomal Location44988195-45003820 bp(+) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) T to C at 45002005 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000038483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046891]
Predicted Effect probably benign
Transcript: ENSMUST00000046891
SMART Domains Protein: ENSMUSP00000038483
Gene: ENSMUSG00000037759

DomainStartEndE-ValueType
low complexity region 35 53 N/A INTRINSIC
Pfam:7tm_1 57 315 5e-26 PFAM
Pfam:7TM_GPCR_Srx 65 243 7.4e-7 PFAM
Pfam:7TM_GPCR_Srsx 66 319 1.2e-7 PFAM
low complexity region 338 356 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168000
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygotes for one targeted null mutation exhibit increased blood pressure when fed a high-salt diet. Female mutants for 2 null alleles have small litters due to impaired ovulation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1b A G 15: 101,203,078 R374G probably damaging Het
Amdhd2 A G 17: 24,157,738 probably null Het
Apol7c A G 15: 77,525,906 M280T probably benign Het
Atl2 T C 17: 79,852,854 M264V probably damaging Het
Ccdc141 C T 2: 77,029,235 probably null Het
Dtx4 T C 19: 12,486,500 probably benign Het
Dyrk4 G A 6: 126,897,171 T152I possibly damaging Het
F5 T A 1: 164,193,538 I1194N probably benign Het
Gadl1 C T 9: 115,948,664 T126M probably damaging Het
Gcnt7 A T 2: 172,454,411 C110* probably null Het
H2-M9 C T 17: 36,640,822 V254M possibly damaging Het
Hadha A T 5: 30,134,186 Het
Kit T C 5: 75,641,188 M621T probably benign Het
Krt73 T C 15: 101,795,840 M422V probably benign Het
Neil2 T C 14: 63,191,808 H12R probably benign Het
Nrsn1 A G 13: 25,253,717 L76P probably damaging Het
Olfr1393 T G 11: 49,280,772 V208G possibly damaging Het
Olfr906 C A 9: 38,488,586 Q186K probably benign Het
Olfr924 T A 9: 38,848,209 Y32N probably damaging Het
Pot1a G A 6: 25,794,616 A23V probably benign Het
Ppp1r14d A G 2: 119,218,360 *147Q probably null Het
Syne3 A T 12: 104,943,428 D716E probably benign Het
Tbc1d9 A G 8: 83,249,473 N554D probably damaging Het
Ushbp1 T A 8: 71,394,376 Q204L possibly damaging Het
Other mutations in Ptger2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00490:Ptger2 APN 14 45001741 splice site probably benign
R0533:Ptger2 UTSW 14 44988982 missense possibly damaging 0.90
R0720:Ptger2 UTSW 14 44989133 missense probably benign
R0973:Ptger2 UTSW 14 44989500 missense probably damaging 1.00
R1643:Ptger2 UTSW 14 44988966 start codon destroyed probably null 0.98
R1737:Ptger2 UTSW 14 45001771 missense probably benign 0.04
R2281:Ptger2 UTSW 14 44989650 missense probably damaging 1.00
R3846:Ptger2 UTSW 14 44989327 missense probably damaging 1.00
R4623:Ptger2 UTSW 14 44989014 missense possibly damaging 0.91
R4735:Ptger2 UTSW 14 45001838 missense possibly damaging 0.89
R5001:Ptger2 UTSW 14 44989367 missense probably damaging 1.00
R5438:Ptger2 UTSW 14 44989644 missense possibly damaging 0.47
R5613:Ptger2 UTSW 14 44989503 missense possibly damaging 0.88
R5767:Ptger2 UTSW 14 44989142 missense probably benign 0.01
Posted On2016-08-02