Incidental Mutation 'IGL03128:Ifi205'
ID410204
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi205
Ensembl Gene ENSMUSG00000054203
Gene Nameinterferon activated gene 205
SynonymsD3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL03128
Quality Score
Status
Chromosome1
Chromosomal Location174011998-174031810 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 174015086 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 348 (V348E)
Ref Sequence ENSEMBL: ENSMUSP00000062409 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059226]
Predicted Effect probably damaging
Transcript: ENSMUST00000059226
AA Change: V348E

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000062409
Gene: ENSMUSG00000054203
AA Change: V348E

DomainStartEndE-ValueType
PYRIN 6 84 9.42e-13 SMART
low complexity region 102 112 N/A INTRINSIC
low complexity region 121 134 N/A INTRINSIC
low complexity region 168 185 N/A INTRINSIC
Pfam:HIN 204 372 2e-76 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox1 A T 11: 116,182,003 L114M probably damaging Het
Bahcc1 G A 11: 120,268,434 probably benign Het
Btrc T A 19: 45,513,520 I226N probably damaging Het
Cth C T 3: 157,921,035 G56D probably damaging Het
Dkk2 T C 3: 132,177,860 probably benign Het
Dock3 A T 9: 107,032,292 M271K probably benign Het
Fam78b T A 1: 167,078,941 L223Q probably damaging Het
Fgl2 A T 5: 21,373,293 M193L probably benign Het
Igkv4-70 T A 6: 69,268,014 K74N probably benign Het
Kdm3b A T 18: 34,827,427 K1355M probably damaging Het
Ltn1 A T 16: 87,415,944 N576K probably benign Het
Ms4a4c A T 19: 11,417,641 probably null Het
Nfic T C 10: 81,406,191 T328A probably benign Het
Npat T A 9: 53,550,033 probably benign Het
Nxpe2 T C 9: 48,319,498 I524V probably benign Het
Orc5 G T 5: 22,516,773 D360E probably damaging Het
Pappa2 C T 1: 158,936,484 E486K probably benign Het
Pde9a C T 17: 31,459,910 H216Y possibly damaging Het
Polr2k C A 15: 36,174,191 P31Q probably damaging Het
Prkdc G T 16: 15,700,744 probably benign Het
Raver1 A T 9: 21,080,742 L385Q probably damaging Het
Slc10a7 C A 8: 78,525,217 T80K probably damaging Het
Smg1 T C 7: 118,203,059 K272R probably benign Het
Supt20 A G 3: 54,708,287 I200V probably benign Het
Tbc1d9 A G 8: 83,166,085 N4S probably benign Het
Tor1aip1 A G 1: 156,007,035 S356P probably damaging Het
Trpm3 A G 19: 22,914,465 Y903C probably damaging Het
Vmn2r71 T G 7: 85,619,587 F333V probably damaging Het
Other mutations in Ifi205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Ifi205 APN 1 174027333 splice site probably benign
IGL02419:Ifi205 APN 1 174017614 missense probably damaging 0.99
IGL02476:Ifi205 APN 1 174015061 missense probably damaging 1.00
IGL03154:Ifi205 APN 1 174017666 splice site probably benign
R0211:Ifi205 UTSW 1 174028428 missense probably benign
R1932:Ifi205 UTSW 1 174028414 missense possibly damaging 0.47
R2397:Ifi205 UTSW 1 174017575 missense possibly damaging 0.64
R3115:Ifi205 UTSW 1 174028335 missense possibly damaging 0.95
R4534:Ifi205 UTSW 1 174017641 missense probably benign 0.16
R4544:Ifi205 UTSW 1 174026573 missense possibly damaging 0.96
R4715:Ifi205 UTSW 1 174028321 missense possibly damaging 0.51
R4977:Ifi205 UTSW 1 174015008 missense probably benign 0.07
R5844:Ifi205 UTSW 1 174026692 splice site probably null
R6061:Ifi205 UTSW 1 174027264 missense possibly damaging 0.91
R6510:Ifi205 UTSW 1 174017565 missense probably damaging 1.00
R7032:Ifi205 UTSW 1 174028350 missense possibly damaging 0.80
R7196:Ifi205 UTSW 1 174026543 missense probably damaging 0.96
R7244:Ifi205 UTSW 1 174017644 nonsense probably null
Posted On2016-08-02