Incidental Mutation 'IGL03129:Sp9'
ID410252
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sp9
Ensembl Gene ENSMUSG00000068859
Gene Nametrans-acting transcription factor 9
Synonyms
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.598) question?
Stock #IGL03129
Quality Score
Status
Chromosome2
Chromosomal Location73271925-73284706 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 73273521 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 140 (T140A)
Ref Sequence ENSEMBL: ENSMUSP00000088322 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090813]
Predicted Effect probably benign
Transcript: ENSMUST00000090813
AA Change: T140A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000088322
Gene: ENSMUSG00000068859
AA Change: T140A

DomainStartEndE-ValueType
low complexity region 53 65 N/A INTRINSIC
low complexity region 71 88 N/A INTRINSIC
low complexity region 92 103 N/A INTRINSIC
low complexity region 233 257 N/A INTRINSIC
low complexity region 268 306 N/A INTRINSIC
ZnF_C2H2 332 356 2.63e0 SMART
ZnF_C2H2 362 386 1.84e-4 SMART
ZnF_C2H2 392 414 5.99e-4 SMART
low complexity region 416 427 N/A INTRINSIC
low complexity region 452 472 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147133
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A G 5: 99,229,379 V403A probably damaging Het
Adpgk T C 9: 59,313,805 L298P probably damaging Het
Akap6 A T 12: 53,140,306 D1501V probably damaging Het
Ank2 C A 3: 126,955,870 E503D probably damaging Het
Ankhd1 T A 18: 36,658,008 Y2478* probably null Het
Col6a3 A G 1: 90,821,862 Y417H probably damaging Het
Csmd1 A G 8: 15,961,521 F2511L probably damaging Het
Dzip3 T C 16: 48,942,083 M602V possibly damaging Het
Efna2 G A 10: 80,188,512 probably null Het
Fzd8 T C 18: 9,214,270 S451P probably damaging Het
Galntl6 A T 8: 58,427,716 D134E probably damaging Het
Gm10334 T C 6: 41,443,498 N98S probably benign Het
Grid2 T C 6: 64,063,904 S277P probably damaging Het
Lcn2 A G 2: 32,387,704 V91A possibly damaging Het
Lrp1b G A 2: 41,312,466 probably benign Het
Lrrc7 T A 3: 158,161,059 Y1015F probably benign Het
Mdn1 T A 4: 32,729,994 C2779S possibly damaging Het
Nlrp10 A T 7: 108,924,911 F454Y probably damaging Het
Obox5 T A 7: 15,758,759 L213Q probably damaging Het
Olfr97 T A 17: 37,232,196 Y58F probably damaging Het
Piezo2 T C 18: 63,114,972 M486V probably benign Het
Plcg1 A C 2: 160,774,526 probably null Het
Polr1b G A 2: 129,115,707 V561I probably benign Het
Polr3c A T 3: 96,719,454 probably benign Het
Prkg1 T A 19: 30,585,281 K523* probably null Het
Sema3b T A 9: 107,599,796 probably benign Het
Zfp507 T C 7: 35,794,206 R471G probably damaging Het
Other mutations in Sp9
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0604:Sp9 UTSW 2 73273638 missense probably benign 0.00
R0718:Sp9 UTSW 2 73273827 missense possibly damaging 0.70
R3423:Sp9 UTSW 2 73273971 missense probably benign 0.00
R3747:Sp9 UTSW 2 73274308 missense probably damaging 0.98
R4335:Sp9 UTSW 2 73274289 missense probably damaging 1.00
R4873:Sp9 UTSW 2 73273618 missense possibly damaging 0.86
R4875:Sp9 UTSW 2 73273618 missense possibly damaging 0.86
R5341:Sp9 UTSW 2 73274514 missense possibly damaging 0.92
R5389:Sp9 UTSW 2 73274297 missense probably damaging 0.99
R5891:Sp9 UTSW 2 73274251 missense probably damaging 1.00
R6938:Sp9 UTSW 2 73273272 missense probably damaging 0.99
R7092:Sp9 UTSW 2 73273771 missense probably damaging 0.99
Z1088:Sp9 UTSW 2 73273230 missense possibly damaging 0.94
Posted On2016-08-02