Incidental Mutation 'IGL03130:Oraov1'
ID410294
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oraov1
Ensembl Gene ENSMUSG00000031072
Gene Nameoral cancer overexpressed 1
SynonymsTAOS1, 2210010N10Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.905) question?
Stock #IGL03130
Quality Score
Status
Chromosome7
Chromosomal Location144915100-144931701 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 144916460 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 42 (E42G)
Ref Sequence ENSEMBL: ENSMUSP00000115840 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033388] [ENSMUST00000105895] [ENSMUST00000128057] [ENSMUST00000141737]
Predicted Effect possibly damaging
Transcript: ENSMUST00000033388
AA Change: E42G

PolyPhen 2 Score 0.853 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000033388
Gene: ENSMUSG00000031072
AA Change: E42G

DomainStartEndE-ValueType
Pfam:Yae1_N 36 74 2.6e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000093964
Predicted Effect possibly damaging
Transcript: ENSMUST00000105895
AA Change: E42G

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101515
Gene: ENSMUSG00000031072
AA Change: E42G

DomainStartEndE-ValueType
Pfam:Yae1_N 36 74 2e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000128057
AA Change: E42G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000115840
Gene: ENSMUSG00000031072
AA Change: E42G

DomainStartEndE-ValueType
Pfam:Yae1_N 36 74 7.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000141737
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147460
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207094
Predicted Effect probably benign
Transcript: ENSMUST00000207453
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227063
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtpbp1 T C 13: 59,474,589 E941G possibly damaging Het
AI314180 A T 4: 58,800,288 C1806S probably benign Het
Akap11 A T 14: 78,510,368 Y1526* probably null Het
Brd1 T C 15: 88,688,374 I1165V probably benign Het
Btbd11 G T 10: 85,388,483 probably null Het
Cdan1 T C 2: 120,727,912 D473G possibly damaging Het
Clstn3 G A 6: 124,459,263 L176F probably damaging Het
Ctif T C 18: 75,521,618 N279S probably benign Het
Dpy19l3 A G 7: 35,752,672 S16P probably benign Het
Fam151b T C 13: 92,450,193 Y244C probably benign Het
Gbf1 T C 19: 46,267,348 M750T possibly damaging Het
Gm11564 T A 11: 99,815,053 T184S unknown Het
Gnptab A G 10: 88,436,371 K958E possibly damaging Het
Hibch T C 1: 52,885,151 S162P possibly damaging Het
Itpr1 T C 6: 108,523,401 S2651P probably benign Het
Lyrm1 A G 7: 119,914,180 D56G probably damaging Het
Manba T C 3: 135,551,159 Y528H probably damaging Het
Npas2 A C 1: 39,313,028 E186D probably damaging Het
Olfr1314 A T 2: 112,091,821 D293E probably benign Het
Olfr371 A T 8: 85,230,629 I45F possibly damaging Het
Olfr867 C A 9: 20,055,372 L30F probably benign Het
Pcdhb6 T A 18: 37,335,587 Y520* probably null Het
Plekhm1 C T 11: 103,377,381 R588H probably benign Het
Psg23 A T 7: 18,610,416 H371Q probably benign Het
Ptpn12 T C 5: 21,002,612 probably benign Het
Rela T C 19: 5,639,881 C120R probably damaging Het
Rps6kc1 T A 1: 190,799,811 I665F probably damaging Het
Spg21 A G 9: 65,473,708 Q99R probably benign Het
St14 A G 9: 31,097,071 probably null Het
Sult1c2 A T 17: 53,830,071 N274K probably benign Het
Syk T C 13: 52,622,732 V256A probably benign Het
Tcte1 A G 17: 45,533,296 D66G probably damaging Het
Tgm4 C T 9: 123,056,515 T374M probably damaging Het
Tns4 T C 11: 99,068,269 H668R probably damaging Het
Tsn C T 1: 118,305,269 A102T possibly damaging Het
Uvssa T A 5: 33,391,845 S350T possibly damaging Het
Vmn1r3 T A 4: 3,185,214 Y31F possibly damaging Het
Vmn2r114 A T 17: 23,296,996 probably benign Het
Vmn2r27 T C 6: 124,192,317 D618G possibly damaging Het
Vmn2r91 T A 17: 18,110,111 probably benign Het
Vti1a T C 19: 55,391,847 Y143H probably damaging Het
Zfand4 T A 6: 116,273,659 Y17N probably damaging Het
Zfp729a T C 13: 67,619,642 probably null Het
Zfp827 A G 8: 79,060,957 T251A probably damaging Het
Other mutations in Oraov1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Oraov1 APN 7 144917668 missense possibly damaging 0.94
IGL00565:Oraov1 APN 7 144916483 missense probably damaging 0.99
PIT4382001:Oraov1 UTSW 7 144916444 missense probably damaging 1.00
R0784:Oraov1 UTSW 7 144919277 missense probably benign 0.33
R1938:Oraov1 UTSW 7 144916468 missense probably damaging 0.99
R4115:Oraov1 UTSW 7 144919646 missense possibly damaging 0.78
R4695:Oraov1 UTSW 7 144928978 unclassified probably null
R6056:Oraov1 UTSW 7 144915286 missense possibly damaging 0.76
R6364:Oraov1 UTSW 7 144919268 missense probably benign 0.00
Posted On2016-08-02