Incidental Mutation 'IGL03141:Sec31b'
ID 410704
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sec31b
Ensembl Gene ENSMUSG00000051984
Gene Name SEC31 homolog B, COPII coat complex component
Synonyms Sec31l2, LOC240667
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # IGL03141
Quality Score
Status
Chromosome 19
Chromosomal Location 44505396-44534287 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 44514759 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107616 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063632] [ENSMUST00000111985]
AlphaFold Q3TZ89
Predicted Effect probably benign
Transcript: ENSMUST00000063632
SMART Domains Protein: ENSMUSP00000064900
Gene: ENSMUSG00000051984

DomainStartEndE-ValueType
Blast:WD40 56 101 5e-18 BLAST
WD40 110 150 4.76e-6 SMART
WD40 159 197 1.53e1 SMART
WD40 200 245 1.85e0 SMART
WD40 249 289 2.15e-4 SMART
WD40 292 332 6.19e-1 SMART
low complexity region 551 561 N/A INTRINSIC
low complexity region 822 841 N/A INTRINSIC
low complexity region 909 929 N/A INTRINSIC
low complexity region 1009 1018 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000111985
SMART Domains Protein: ENSMUSP00000107616
Gene: ENSMUSG00000051984

DomainStartEndE-ValueType
WD40 2 40 1.53e1 SMART
WD40 43 88 1.85e0 SMART
WD40 92 132 2.15e-4 SMART
WD40 135 175 6.19e-1 SMART
Pfam:Sec16_C 394 612 1.3e-7 PFAM
low complexity region 665 684 N/A INTRINSIC
low complexity region 752 772 N/A INTRINSIC
low complexity region 852 861 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adm2 T C 15: 89,207,531 (GRCm39) I14T probably benign Het
AY761185 G A 8: 21,434,576 (GRCm39) R51C possibly damaging Het
Cenpt T A 8: 106,578,573 (GRCm39) T15S probably damaging Het
Cotl1 T C 8: 120,537,022 (GRCm39) K131E possibly damaging Het
D5Ertd579e T A 5: 36,770,621 (GRCm39) D1258V possibly damaging Het
Decr1 A T 4: 15,932,902 (GRCm39) I88K probably damaging Het
Efcab3 T C 11: 104,986,696 (GRCm39) S5408P probably damaging Het
Gsto2 T C 19: 47,863,312 (GRCm39) Y63H probably damaging Het
Lrp2 A T 2: 69,307,370 (GRCm39) D2896E probably damaging Het
Lrrc3b T G 14: 15,358,390 (GRCm38) D72A probably damaging Het
Npas1 T C 7: 16,199,063 (GRCm39) E164G probably damaging Het
Or6f1 T A 7: 85,970,909 (GRCm39) I84F probably damaging Het
Parp14 C A 16: 35,659,663 (GRCm39) R1653L probably benign Het
Polq A G 16: 36,837,720 (GRCm39) probably benign Het
Slc7a11 C T 3: 50,336,334 (GRCm39) A337T possibly damaging Het
Snapc3 A G 4: 83,353,523 (GRCm39) I187M probably damaging Het
Sorcs2 T C 5: 36,222,699 (GRCm39) E352G probably benign Het
Spout1 A C 2: 30,065,067 (GRCm39) V311G probably damaging Het
Syne1 T A 10: 5,374,261 (GRCm39) K182M probably damaging Het
Vmn2r110 A G 17: 20,803,976 (GRCm39) S200P possibly damaging Het
Other mutations in Sec31b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Sec31b APN 19 44,515,480 (GRCm39) missense probably damaging 1.00
IGL01308:Sec31b APN 19 44,512,122 (GRCm39) missense probably benign 0.02
IGL02404:Sec31b APN 19 44,523,227 (GRCm39) missense probably damaging 0.99
IGL02663:Sec31b APN 19 44,522,717 (GRCm39) missense probably damaging 1.00
IGL02728:Sec31b APN 19 44,511,554 (GRCm39) missense probably damaging 0.96
IGL02830:Sec31b APN 19 44,520,142 (GRCm39) missense probably damaging 1.00
IGL03247:Sec31b APN 19 44,507,379 (GRCm39) missense possibly damaging 0.62
R0049:Sec31b UTSW 19 44,508,847 (GRCm39) splice site probably benign
R0137:Sec31b UTSW 19 44,522,821 (GRCm39) missense probably damaging 1.00
R0238:Sec31b UTSW 19 44,513,908 (GRCm39) unclassified probably benign
R0239:Sec31b UTSW 19 44,513,908 (GRCm39) unclassified probably benign
R0468:Sec31b UTSW 19 44,506,947 (GRCm39) splice site probably benign
R0504:Sec31b UTSW 19 44,523,225 (GRCm39) missense probably damaging 1.00
R0565:Sec31b UTSW 19 44,512,992 (GRCm39) missense probably damaging 1.00
R0627:Sec31b UTSW 19 44,514,046 (GRCm39) missense probably benign
R0749:Sec31b UTSW 19 44,512,945 (GRCm39) missense probably damaging 0.96
R0815:Sec31b UTSW 19 44,506,612 (GRCm39) nonsense probably null
R1162:Sec31b UTSW 19 44,506,087 (GRCm39) nonsense probably null
R1398:Sec31b UTSW 19 44,512,104 (GRCm39) missense probably benign 0.04
R1436:Sec31b UTSW 19 44,524,634 (GRCm39) missense probably damaging 0.99
R1538:Sec31b UTSW 19 44,507,025 (GRCm39) missense probably benign 0.42
R1599:Sec31b UTSW 19 44,511,592 (GRCm39) missense possibly damaging 0.92
R2044:Sec31b UTSW 19 44,524,595 (GRCm39) missense probably benign 0.07
R2135:Sec31b UTSW 19 44,523,135 (GRCm39) missense probably damaging 0.99
R2167:Sec31b UTSW 19 44,531,792 (GRCm39) missense possibly damaging 0.89
R2211:Sec31b UTSW 19 44,511,589 (GRCm39) missense probably damaging 1.00
R2938:Sec31b UTSW 19 44,524,618 (GRCm39) missense probably damaging 0.99
R3113:Sec31b UTSW 19 44,506,624 (GRCm39) nonsense probably null
R4110:Sec31b UTSW 19 44,512,968 (GRCm39) missense possibly damaging 0.62
R4111:Sec31b UTSW 19 44,512,968 (GRCm39) missense possibly damaging 0.62
R4113:Sec31b UTSW 19 44,512,968 (GRCm39) missense possibly damaging 0.62
R4158:Sec31b UTSW 19 44,513,625 (GRCm39) missense probably benign 0.34
R4226:Sec31b UTSW 19 44,520,149 (GRCm39) missense probably benign
R4646:Sec31b UTSW 19 44,515,060 (GRCm39) missense probably benign 0.00
R4732:Sec31b UTSW 19 44,521,116 (GRCm39) missense probably damaging 1.00
R4733:Sec31b UTSW 19 44,521,116 (GRCm39) missense probably damaging 1.00
R4795:Sec31b UTSW 19 44,520,185 (GRCm39) missense probably benign 0.00
R4877:Sec31b UTSW 19 44,524,172 (GRCm39) missense probably damaging 1.00
R5150:Sec31b UTSW 19 44,508,970 (GRCm39) missense probably benign 0.08
R5377:Sec31b UTSW 19 44,507,076 (GRCm39) missense probably damaging 1.00
R5381:Sec31b UTSW 19 44,522,810 (GRCm39) missense probably damaging 1.00
R5708:Sec31b UTSW 19 44,511,583 (GRCm39) missense probably damaging 1.00
R6002:Sec31b UTSW 19 44,524,203 (GRCm39) missense probably benign 0.04
R6185:Sec31b UTSW 19 44,531,723 (GRCm39) missense possibly damaging 0.77
R6675:Sec31b UTSW 19 44,512,214 (GRCm39) missense probably benign
R6946:Sec31b UTSW 19 44,522,755 (GRCm39) missense probably damaging 1.00
R7139:Sec31b UTSW 19 44,507,375 (GRCm39) missense probably benign 0.00
R7237:Sec31b UTSW 19 44,506,147 (GRCm39) missense probably damaging 1.00
R7270:Sec31b UTSW 19 44,511,482 (GRCm39) missense probably benign 0.00
R7340:Sec31b UTSW 19 44,517,161 (GRCm39) missense probably benign 0.00
R7505:Sec31b UTSW 19 44,532,146 (GRCm39) missense probably damaging 1.00
R7584:Sec31b UTSW 19 44,519,995 (GRCm39) splice site probably null
R7584:Sec31b UTSW 19 44,531,762 (GRCm39) missense probably damaging 0.99
R7763:Sec31b UTSW 19 44,512,274 (GRCm39) critical splice acceptor site probably null
R7777:Sec31b UTSW 19 44,512,212 (GRCm39) nonsense probably null
R7900:Sec31b UTSW 19 44,514,669 (GRCm39) missense probably damaging 1.00
R7952:Sec31b UTSW 19 44,508,979 (GRCm39) missense probably benign 0.01
R8057:Sec31b UTSW 19 44,507,804 (GRCm39) missense probably damaging 1.00
R8197:Sec31b UTSW 19 44,512,955 (GRCm39) missense probably benign 0.25
R8739:Sec31b UTSW 19 44,507,620 (GRCm39) missense probably benign 0.16
R8822:Sec31b UTSW 19 44,507,702 (GRCm39) missense probably benign 0.02
R8837:Sec31b UTSW 19 44,506,106 (GRCm39) nonsense probably null
R8916:Sec31b UTSW 19 44,520,783 (GRCm39) missense
R9069:Sec31b UTSW 19 44,507,741 (GRCm39) missense probably damaging 0.98
R9259:Sec31b UTSW 19 44,505,855 (GRCm39) missense probably damaging 1.00
R9493:Sec31b UTSW 19 44,509,021 (GRCm39) missense probably damaging 1.00
RF023:Sec31b UTSW 19 44,524,226 (GRCm39) missense probably damaging 1.00
Z1177:Sec31b UTSW 19 44,505,753 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02