Incidental Mutation 'IGL03142:Vmn2r121'
ID410705
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r121
Ensembl Gene ENSMUSG00000072049
Gene Namevomeronasal 2, receptor 121
SynonymsEG625699
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.100) question?
Stock #IGL03142
Quality Score
Status
ChromosomeX
Chromosomal Location124127339-124135910 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 124132938 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 174 (D174G)
Ref Sequence ENSEMBL: ENSMUSP00000092067 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094491]
Predicted Effect possibly damaging
Transcript: ENSMUST00000094491
AA Change: D174G

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: D174G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 448 3.2e-26 PFAM
Pfam:NCD3G 506 560 2.1e-19 PFAM
Pfam:7tm_3 593 828 3.8e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc88c T C 12: 100,947,198 S523G probably damaging Het
Ccnb1 A T 13: 100,783,531 D157E probably damaging Het
Cfap70 T C 14: 20,397,215 T1055A probably damaging Het
Fgfr1op T A 17: 8,192,209 S331R probably damaging Het
Fn1 C A 1: 71,637,296 R592L probably damaging Het
Frmpd4 T A X: 167,479,483 D550V possibly damaging Het
Gcm2 A G 13: 41,103,235 V346A probably benign Het
Gm10112 C T X: 111,168,350 T4I probably damaging Het
Gm3115 T C 14: 4,084,302 probably benign Het
Has2 A T 15: 56,682,095 I37N possibly damaging Het
Hmgn3 A G 9: 83,146,429 probably benign Het
Klhl29 T A 12: 5,137,603 N254Y probably damaging Het
Kti12 A G 4: 108,848,165 Y92C probably damaging Het
Mgat5 A C 1: 127,412,223 Q447P probably damaging Het
Mlh3 C A 12: 85,250,301 probably null Het
Mrpl45 T C 11: 97,315,925 W18R probably benign Het
Mtor A G 4: 148,453,899 D138G probably benign Het
Mycbp2 C T 14: 103,298,776 C246Y probably damaging Het
Mylk4 A T 13: 32,720,599 V415E probably damaging Het
Olfm3 A T 3: 115,097,030 Q124L probably damaging Het
Olfr1423 A T 19: 12,036,388 M118K probably damaging Het
Pam C T 1: 97,894,386 G298R probably damaging Het
Pappa2 A C 1: 158,854,931 I849R probably damaging Het
Pde3a T A 6: 141,492,299 D1031E probably benign Het
Pik3cb A T 9: 99,065,562 S521T probably benign Het
Pkn1 A G 8: 83,671,023 F824L possibly damaging Het
Pspn C T 17: 56,999,566 R121Q probably benign Het
Ric1 A G 19: 29,600,980 D1195G possibly damaging Het
Sin3b A G 8: 72,744,568 D381G probably damaging Het
Slc37a3 T C 6: 39,359,985 probably null Het
Smtn T A 11: 3,532,601 K124* probably null Het
Tbce A G 13: 14,019,864 V70A possibly damaging Het
Tmem251 G A 12: 102,744,674 S52N probably damaging Het
Tti1 A G 2: 158,000,677 Y811H probably damaging Het
Uggt2 T C 14: 118,998,191 Y1424C probably damaging Het
Upf1 A G 8: 70,333,327 V994A probably benign Het
Other mutations in Vmn2r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r121 APN X 124127802 missense probably benign 0.04
IGL00990:Vmn2r121 APN X 124127783 missense possibly damaging 0.95
IGL00990:Vmn2r121 APN X 124133716 missense probably benign 0.00
IGL01125:Vmn2r121 APN X 124132807 missense probably damaging 0.99
IGL01450:Vmn2r121 APN X 124131191 missense possibly damaging 0.57
IGL01619:Vmn2r121 APN X 124132300 missense probably benign
IGL01797:Vmn2r121 APN X 124131351 splice site probably benign
IGL02227:Vmn2r121 APN X 124132681 missense probably benign 0.44
IGL02971:Vmn2r121 APN X 124127894 missense probably damaging 1.00
IGL03058:Vmn2r121 APN X 124132921 missense probably benign 0.00
IGL03183:Vmn2r121 APN X 124132326 missense probably benign 0.03
E0370:Vmn2r121 UTSW X 124127920 missense probably benign 0.01
R0196:Vmn2r121 UTSW X 124132182 missense probably benign 0.03
R1381:Vmn2r121 UTSW X 124128140 missense probably damaging 1.00
R1399:Vmn2r121 UTSW X 124129848 missense possibly damaging 0.94
R1423:Vmn2r121 UTSW X 124129905 missense possibly damaging 0.52
R1687:Vmn2r121 UTSW X 124132791 missense probably benign 0.39
R2121:Vmn2r121 UTSW X 124133742 splice site probably null
R2124:Vmn2r121 UTSW X 124133742 splice site probably null
R3151:Vmn2r121 UTSW X 124131152 missense probably benign 0.20
R4460:Vmn2r121 UTSW X 124128584 missense probably benign 0.01
R4735:Vmn2r121 UTSW X 124128638 missense probably benign
R5332:Vmn2r121 UTSW X 124133575 missense probably benign
R6102:Vmn2r121 UTSW X 124133575 missense probably benign
X0023:Vmn2r121 UTSW X 124135657 missense possibly damaging 0.64
Posted On2016-08-02