Incidental Mutation 'IGL00577:Tas2r119'
ID 4108
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r119
Ensembl Gene ENSMUSG00000045267
Gene Name taste receptor, type 2, member 119
Synonyms mt2r19, mGR19, Tas2r19, T2R19
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00577
Quality Score
Status
Chromosome 15
Chromosomal Location 32177435-32178440 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32177599 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 55 (I55T)
Ref Sequence ENSEMBL: ENSMUSP00000050277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057633]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000057633
AA Change: I55T

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: I55T

DomainStartEndE-ValueType
Pfam:TAS2R 1 293 1.1e-90 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ang6 T A 14: 44,239,458 (GRCm39) Y90F probably benign Het
Arhgef6 T A X: 56,290,992 (GRCm39) probably null Het
Ccdc88a A G 11: 29,374,772 (GRCm39) E115G probably damaging Het
Ceacam12 T A 7: 17,801,186 (GRCm39) V55E probably damaging Het
Depdc1a A T 3: 159,228,375 (GRCm39) R376* probably null Het
Dop1a A T 9: 86,402,999 (GRCm39) I1398F probably damaging Het
Eif2s1 T G 12: 78,913,420 (GRCm39) N40K possibly damaging Het
Epb41 T A 4: 131,702,042 (GRCm39) H531L probably benign Het
Frrs1 T A 3: 116,696,049 (GRCm39) W523R probably damaging Het
Gpatch8 T C 11: 102,369,704 (GRCm39) D1278G probably damaging Het
Mybpc1 C T 10: 88,372,246 (GRCm39) A795T probably damaging Het
Nrdc T C 4: 108,903,884 (GRCm39) probably benign Het
Os9 C T 10: 126,933,845 (GRCm39) R524K probably benign Het
Pisd T C 5: 32,895,756 (GRCm39) I441V probably benign Het
Plekha5 T A 6: 140,515,822 (GRCm39) probably benign Het
Prnp A G 2: 131,779,031 (GRCm39) R228G probably benign Het
Prrc2c G A 1: 162,525,685 (GRCm39) P307L unknown Het
Prss1 T C 6: 41,439,645 (GRCm39) V126A possibly damaging Het
Ptpn21 G A 12: 98,699,860 (GRCm39) S18F probably damaging Het
Setdb1 T C 3: 95,245,888 (GRCm39) D678G probably damaging Het
Sltm G T 9: 70,486,624 (GRCm39) V430L probably damaging Het
Sphkap A G 1: 83,256,565 (GRCm39) S395P probably damaging Het
Tmc3 A C 7: 83,252,682 (GRCm39) E361A probably null Het
Uggt2 A T 14: 119,272,312 (GRCm39) S922T possibly damaging Het
Znhit1 A T 5: 137,011,437 (GRCm39) Y125* probably null Het
Other mutations in Tas2r119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01522:Tas2r119 APN 15 32,178,339 (GRCm39) missense probably benign 0.15
IGL01548:Tas2r119 APN 15 32,178,123 (GRCm39) missense probably damaging 1.00
IGL01826:Tas2r119 APN 15 32,177,548 (GRCm39) missense probably damaging 1.00
IGL02432:Tas2r119 APN 15 32,177,853 (GRCm39) missense probably benign 0.06
IGL02585:Tas2r119 APN 15 32,177,679 (GRCm39) missense probably benign 0.04
R2248:Tas2r119 UTSW 15 32,178,297 (GRCm39) missense possibly damaging 0.51
R2432:Tas2r119 UTSW 15 32,178,165 (GRCm39) missense possibly damaging 0.80
R5098:Tas2r119 UTSW 15 32,178,228 (GRCm39) missense probably benign 0.03
R5624:Tas2r119 UTSW 15 32,178,114 (GRCm39) missense probably damaging 1.00
R5819:Tas2r119 UTSW 15 32,177,452 (GRCm39) missense probably damaging 1.00
R5901:Tas2r119 UTSW 15 32,177,932 (GRCm39) missense possibly damaging 0.84
R6363:Tas2r119 UTSW 15 32,178,034 (GRCm39) missense possibly damaging 0.91
R6495:Tas2r119 UTSW 15 32,177,676 (GRCm39) missense probably benign
R6521:Tas2r119 UTSW 15 32,178,319 (GRCm39) missense probably damaging 1.00
R7574:Tas2r119 UTSW 15 32,178,279 (GRCm39) missense probably damaging 1.00
R9004:Tas2r119 UTSW 15 32,178,109 (GRCm39) missense probably damaging 1.00
R9015:Tas2r119 UTSW 15 32,178,226 (GRCm39) missense probably damaging 1.00
R9193:Tas2r119 UTSW 15 32,177,932 (GRCm39) missense probably benign 0.02
X0063:Tas2r119 UTSW 15 32,178,301 (GRCm39) missense possibly damaging 0.95
Posted On 2012-04-20