Incidental Mutation 'IGL03144:Stk25'
ID 410815
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk25
Ensembl Gene ENSMUSG00000026277
Gene Name serine/threonine kinase 25 (yeast)
Synonyms SOK-1, Ste20-like, 1500019J11Rik, Ysk1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03144
Quality Score
Status
Chromosome 1
Chromosomal Location 93548473-93581937 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 93556858 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 53 (L53F)
Ref Sequence ENSEMBL: ENSMUSP00000140396 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027498] [ENSMUST00000133769] [ENSMUST00000186287]
AlphaFold Q9Z2W1
Predicted Effect probably damaging
Transcript: ENSMUST00000027498
AA Change: L53F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027498
Gene: ENSMUSG00000026277
AA Change: L53F

DomainStartEndE-ValueType
S_TKc 20 270 2.92e-98 SMART
low complexity region 292 314 N/A INTRINSIC
PDB:3W8H|B 355 426 8e-43 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125778
Predicted Effect probably damaging
Transcript: ENSMUST00000133769
AA Change: L53F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000117765
Gene: ENSMUSG00000026277
AA Change: L53F

DomainStartEndE-ValueType
Pfam:Pkinase 20 233 1.7e-63 PFAM
Pfam:Pkinase_Tyr 20 233 2.1e-47 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151068
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154008
Predicted Effect probably damaging
Transcript: ENSMUST00000186287
AA Change: L53F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140396
Gene: ENSMUSG00000026277
AA Change: L53F

DomainStartEndE-ValueType
STYKc 20 107 1.9e-4 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Germ line null mutants display normal cortical layers and neuronal migration. Acute loss of expression results in impaired neuronal migration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 C A 17: 24,600,938 (GRCm39) Q451K probably benign Het
Acly A T 11: 100,405,909 (GRCm39) D294E possibly damaging Het
Arid3a C T 10: 79,782,316 (GRCm39) probably benign Het
Ascc3 T C 10: 50,643,539 (GRCm39) V1830A probably benign Het
Atp6v1b1 T C 6: 83,735,333 (GRCm39) V467A probably benign Het
Ccdc171 A T 4: 83,736,327 (GRCm39) I1233L probably damaging Het
Ccdc74a C A 16: 17,466,730 (GRCm39) Q146K possibly damaging Het
Cdh26 A G 2: 178,109,967 (GRCm39) D420G probably damaging Het
Ceacam20 T C 7: 19,705,444 (GRCm39) V145A possibly damaging Het
Cmya5 C A 13: 93,227,376 (GRCm39) A2571S probably damaging Het
Cog2 T C 8: 125,267,763 (GRCm39) S360P probably damaging Het
Col26a1 G T 5: 136,794,202 (GRCm39) T132N probably damaging Het
Col6a2 T A 10: 76,450,259 (GRCm39) H224L probably benign Het
Cpm C T 10: 117,519,319 (GRCm39) S409L probably benign Het
Dock4 G T 12: 40,742,906 (GRCm39) probably benign Het
Dpy19l2 T A 9: 24,557,603 (GRCm39) N391Y possibly damaging Het
Exosc9 G A 3: 36,608,284 (GRCm39) G126D probably damaging Het
Eya3 T C 4: 132,420,453 (GRCm39) S256P probably benign Het
Fat3 T C 9: 16,286,541 (GRCm39) D994G probably damaging Het
Fat4 A G 3: 39,011,008 (GRCm39) Q2036R possibly damaging Het
Fryl T C 5: 73,258,798 (GRCm39) Q662R probably null Het
Gm13271 A G 4: 88,673,636 (GRCm39) R178G probably benign Het
Gpr165 T A X: 95,760,560 (GRCm39) L279Q probably damaging Het
Htr1b A G 9: 81,513,998 (GRCm39) L203P probably damaging Het
Kcnb2 T C 1: 15,780,112 (GRCm39) L328P probably damaging Het
Klhl26 C T 8: 70,905,214 (GRCm39) R198H probably damaging Het
Nhsl2 A G X: 101,123,115 (GRCm39) R973G possibly damaging Het
Nmi A T 2: 51,842,546 (GRCm39) F182Y probably damaging Het
Nop2 T A 6: 125,114,475 (GRCm39) probably null Het
Nrn1 C A 13: 36,914,080 (GRCm39) probably null Het
Ooep G T 9: 78,285,289 (GRCm39) A109E possibly damaging Het
Or1j21 A G 2: 36,684,093 (GRCm39) T282A probably benign Het
Pan3 T C 5: 147,387,591 (GRCm39) probably benign Het
Pcdhb6 A G 18: 37,467,459 (GRCm39) N127D probably damaging Het
Rabgap1 G A 2: 37,430,544 (GRCm39) R695H probably damaging Het
Rxrg G A 1: 167,426,327 (GRCm39) G3R possibly damaging Het
Slc17a3 T C 13: 24,030,423 (GRCm39) M178T probably benign Het
Slc39a8 A G 3: 135,589,971 (GRCm39) E287G probably benign Het
Slc44a5 G T 3: 153,949,177 (GRCm39) D217Y possibly damaging Het
Slc4a10 G T 2: 62,080,810 (GRCm39) V346L probably benign Het
Slc9a4 T C 1: 40,651,362 (GRCm39) Y547H probably damaging Het
St6galnac3 A C 3: 152,911,164 (GRCm39) Y266D probably damaging Het
Stard6 A T 18: 70,609,182 (GRCm39) Y3F possibly damaging Het
Tep1 A T 14: 51,081,474 (GRCm39) probably benign Het
Tmem151a T A 19: 5,135,400 (GRCm39) M1L probably benign Het
Trim10 T C 17: 37,187,740 (GRCm39) S319P probably damaging Het
Trmt44 G T 5: 35,721,766 (GRCm39) P466T probably benign Het
Unc79 T C 12: 103,008,401 (GRCm39) I256T probably damaging Het
Vmn2r125 G T 4: 156,702,314 (GRCm39) L33F possibly damaging Het
Other mutations in Stk25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01291:Stk25 APN 1 93,551,145 (GRCm39) splice site probably null
IGL02952:Stk25 APN 1 93,553,798 (GRCm39) missense probably damaging 1.00
ANU05:Stk25 UTSW 1 93,551,145 (GRCm39) splice site probably null
IGL02980:Stk25 UTSW 1 93,555,390 (GRCm39) missense probably damaging 1.00
PIT4531001:Stk25 UTSW 1 93,552,346 (GRCm39) missense probably benign
R0240:Stk25 UTSW 1 93,554,782 (GRCm39) missense probably damaging 1.00
R0240:Stk25 UTSW 1 93,554,782 (GRCm39) missense probably damaging 1.00
R0555:Stk25 UTSW 1 93,552,313 (GRCm39) missense probably benign 0.00
R1178:Stk25 UTSW 1 93,551,111 (GRCm39) unclassified probably benign
R1406:Stk25 UTSW 1 93,552,875 (GRCm39) unclassified probably benign
R1493:Stk25 UTSW 1 93,553,322 (GRCm39) missense probably benign 0.04
R2875:Stk25 UTSW 1 93,556,973 (GRCm39) missense possibly damaging 0.91
R4657:Stk25 UTSW 1 93,553,378 (GRCm39) unclassified probably benign
R4668:Stk25 UTSW 1 93,553,205 (GRCm39) missense probably damaging 1.00
R4686:Stk25 UTSW 1 93,551,142 (GRCm39) splice site probably null
R5089:Stk25 UTSW 1 93,552,330 (GRCm39) missense probably benign 0.05
R5493:Stk25 UTSW 1 93,563,031 (GRCm39) missense probably benign
R6013:Stk25 UTSW 1 93,553,181 (GRCm39) critical splice donor site probably null
R8723:Stk25 UTSW 1 93,553,666 (GRCm39) missense probably damaging 1.00
R8905:Stk25 UTSW 1 93,556,929 (GRCm39) missense probably damaging 1.00
R9249:Stk25 UTSW 1 93,552,806 (GRCm39) missense probably benign
R9274:Stk25 UTSW 1 93,552,806 (GRCm39) missense probably benign
X0063:Stk25 UTSW 1 93,553,683 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02