Mutagenetix > Incidental Mutation

Incidental Mutation 'R0066:Pkd1l3'

41083

Institutional Source

Beutler Lab

Gene Symbol

Pkd1l3

Ensembl Gene

ENSMUSG00000048827

Gene Name

polycystic kidney disease 1 like 3

Synonyms

MMRRC Submission

038357-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0066 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

110340828-110399305 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 110347103 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Cysteine at position 159 (G159C)

Ref Sequence

ENSEMBL: ENSMUSP00000148592 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057344] [ENSMUST00000109242] [ENSMUST00000212537]

AlphaFold

Q2EG98

Predicted Effect

unknown
Transcript: ENSMUST00000057344
AA Change: G159C

SMART Domains

Protein: ENSMUSP00000051512
Gene: ENSMUSG00000048827
AA Change: G159C

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
CLECT	26	142	4.25e-1	SMART
internal_repeat_2	143	245	2.25e-8	PROSPERO
low complexity region	246	270	N/A	INTRINSIC
low complexity region	272	296	N/A	INTRINSIC
low complexity region	298	322	N/A	INTRINSIC
low complexity region	324	348	N/A	INTRINSIC
internal_repeat_1	349	431	1.22e-8	PROSPERO
internal_repeat_2	378	466	2.25e-8	PROSPERO
internal_repeat_1	518	731	1.22e-8	PROSPERO
GPS	1007	1056	3.62e-5	SMART
transmembrane domain	1075	1094	N/A	INTRINSIC
LH2	1119	1238	1.01e-9	SMART
transmembrane domain	1282	1304	N/A	INTRINSIC
transmembrane domain	1319	1341	N/A	INTRINSIC
low complexity region	1398	1408	N/A	INTRINSIC
low complexity region	1451	1460	N/A	INTRINSIC
low complexity region	1484	1497	N/A	INTRINSIC
transmembrane domain	1534	1556	N/A	INTRINSIC
transmembrane domain	1576	1595	N/A	INTRINSIC
Pfam:PKD_channel	1695	2110	2.8e-86	PFAM
Pfam:Ion_trans	1858	2114	2.9e-9	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000109242
AA Change: G159C

SMART Domains

Protein: ENSMUSP00000104865
Gene: ENSMUSG00000048827
AA Change: G159C

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
CLECT	26	142	4.25e-1	SMART
internal_repeat_2	143	245	2.63e-8	PROSPERO
low complexity region	246	270	N/A	INTRINSIC
low complexity region	272	296	N/A	INTRINSIC
low complexity region	298	322	N/A	INTRINSIC
low complexity region	324	348	N/A	INTRINSIC
internal_repeat_1	349	440	3.96e-14	PROSPERO
internal_repeat_2	378	466	2.63e-8	PROSPERO
internal_repeat_1	518	724	3.96e-14	PROSPERO
GPS	1017	1066	3.62e-5	SMART
transmembrane domain	1085	1104	N/A	INTRINSIC
LH2	1129	1248	1.01e-9	SMART
transmembrane domain	1292	1314	N/A	INTRINSIC
transmembrane domain	1329	1351	N/A	INTRINSIC
low complexity region	1408	1418	N/A	INTRINSIC
low complexity region	1461	1470	N/A	INTRINSIC
low complexity region	1494	1507	N/A	INTRINSIC
transmembrane domain	1544	1566	N/A	INTRINSIC
transmembrane domain	1586	1605	N/A	INTRINSIC
Pfam:PKD_channel	1705	2120	1.3e-86	PFAM
Pfam:Ion_trans	1868	2124	4.3e-9	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000212537
AA Change: G159C

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212609

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 93.0%

Validation Efficiency

100% (107/107)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and grossly normal and exhibit normal taste responsiveness in various behavioral and electrophysiological tests of taste function. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810064F22Rik	A	G	9: 22,119,177 (GRCm39)		noncoding transcript	Het
5530400C23Rik	A	T	6: 133,269,287 (GRCm39)		probably benign	Het
Aco2	T	C	15: 81,787,666 (GRCm39)		probably benign	Het
Arap3	A	T	18: 38,129,760 (GRCm39)	S134T	probably benign	Het
Arsa	T	A	15: 89,358,539 (GRCm39)	M288L	possibly damaging	Het
Atg2b	A	T	12: 105,614,708 (GRCm39)	D1074E	probably benign	Het
Baiap2l1	A	T	5: 144,221,372 (GRCm39)	I174N	probably damaging	Het
Bpifb9a	A	T	2: 154,108,761 (GRCm39)	N421Y	possibly damaging	Het
Btn2a2	T	A	13: 23,662,655 (GRCm39)	I432L	probably benign	Het
Ccdc150	A	G	1: 54,395,850 (GRCm39)	I778V	probably benign	Het
Cd200r2	G	A	16: 44,730,037 (GRCm39)	V194I	possibly damaging	Het
Cep350	A	C	1: 155,786,964 (GRCm39)	L1421R	probably damaging	Het
Col24a1	G	A	3: 145,250,899 (GRCm39)	A1633T	probably damaging	Het
Col6a6	A	T	9: 105,579,412 (GRCm39)	C1938S	probably damaging	Het
Cspg4	A	T	9: 56,795,418 (GRCm39)	D1051V	probably damaging	Het
Cstf1	T	A	2: 172,214,976 (GRCm39)	N32K	probably benign	Het
Ctrb1	G	A	8: 112,413,269 (GRCm39)	R248*	probably null	Het
Cyp2d11	T	A	15: 82,275,958 (GRCm39)	M208L	probably benign	Het
Dbt	A	G	3: 116,337,478 (GRCm39)	Q334R	probably benign	Het
Dcaf12	A	G	4: 41,298,338 (GRCm39)	V270A	probably damaging	Het
Dis3l	T	A	9: 64,226,447 (GRCm39)	N361I	probably benign	Het
Dnah10	A	T	5: 124,840,140 (GRCm39)	D1315V	probably benign	Het
Dnah11	A	G	12: 118,090,621 (GRCm39)	F1080S	probably benign	Het
Dnm3	A	G	1: 162,234,930 (GRCm39)	V70A	probably damaging	Het
Dpy19l1	A	C	9: 24,325,705 (GRCm39)	M700R	possibly damaging	Het
Dpy19l2	G	A	9: 24,557,679 (GRCm39)		probably benign	Het
Dst	C	A	1: 34,228,634 (GRCm39)	H2254N	possibly damaging	Het
Epm2aip1	A	G	9: 111,101,531 (GRCm39)	N168S	probably benign	Het
Fchsd2	A	G	7: 100,927,631 (GRCm39)	Y691C	possibly damaging	Het
Fndc8	A	T	11: 82,788,398 (GRCm39)	D76V	probably benign	Het
Frmd4a	T	C	2: 4,477,963 (GRCm39)	L48P	probably damaging	Het
Gimap6	T	A	6: 48,679,404 (GRCm39)	I211F	probably damaging	Het
Gm15130	A	G	2: 110,969,284 (GRCm39)		probably benign	Het
Gm43302	T	A	5: 105,438,766 (GRCm39)	I41F	probably damaging	Het
Gm5698	C	T	1: 31,016,614 (GRCm39)	V146I	probably benign	Het
Gpatch1	G	A	7: 34,986,652 (GRCm39)	S768L	probably damaging	Het
Grb14	T	G	2: 64,768,836 (GRCm39)		probably null	Het
Hnrnpd	T	C	5: 100,112,560 (GRCm39)	E222G	probably damaging	Het
Il4ra	C	T	7: 125,175,403 (GRCm39)	P537L	possibly damaging	Het
Kalrn	T	C	16: 34,024,327 (GRCm39)	D610G	probably damaging	Het
Kcnh4	T	C	11: 100,648,626 (GRCm39)	H26R	probably benign	Het
Kctd2	T	G	11: 115,320,343 (GRCm39)		probably benign	Het
Khdrbs3	T	A	15: 68,866,886 (GRCm39)		probably benign	Het
Macf1	G	A	4: 123,325,943 (GRCm39)	Q3066*	probably null	Het
Mfn2	G	A	4: 147,969,902 (GRCm39)		probably benign	Het
Mmab	T	C	5: 114,574,526 (GRCm39)		probably benign	Het
Mrc1	T	C	2: 14,266,011 (GRCm39)	S310P	probably benign	Het
Mrps21	T	C	3: 95,770,197 (GRCm39)	Y44C	probably null	Het
Myh10	T	A	11: 68,590,317 (GRCm39)	F121Y	probably damaging	Het
Myo1f	A	G	17: 33,820,677 (GRCm39)	D840G	probably damaging	Het
Neb	T	A	2: 52,196,542 (GRCm39)	D553V	probably damaging	Het
Nol6	G	T	4: 41,119,572 (GRCm39)		probably benign	Het
Npr2	G	T	4: 43,632,329 (GRCm39)	V49L	probably benign	Het
Ntsr2	T	C	12: 16,704,120 (GRCm39)	I207T	probably benign	Het
Nwd1	T	A	8: 73,438,484 (GRCm39)	S1552T	probably benign	Het
Oas3	T	A	5: 120,896,940 (GRCm39)	I894F	probably damaging	Het
Oprd1	A	G	4: 131,841,299 (GRCm39)	F220L	probably benign	Het
Or11j4	T	A	14: 50,630,659 (GRCm39)	F149I	probably benign	Het
Or2aj4	T	A	16: 19,384,799 (GRCm39)	Y278F	probably damaging	Het
Or2r2	A	T	6: 42,463,869 (GRCm39)	M86K	probably benign	Het
Or8b57	T	C	9: 40,003,983 (GRCm39)	N93S	possibly damaging	Het
Plcb4	T	C	2: 135,803,689 (GRCm39)	S521P	probably benign	Het
Plcl1	A	T	1: 55,752,634 (GRCm39)	I993F	probably damaging	Het
Plcxd1	T	A	5: 110,249,368 (GRCm39)	V65E	probably damaging	Het
Plekha7	T	C	7: 115,756,743 (GRCm39)	S640G	probably damaging	Het
Ptprn2	A	C	12: 117,240,222 (GRCm39)	N993T	probably benign	Het
Rabepk	T	C	2: 34,685,318 (GRCm39)	D26G	possibly damaging	Het
Reck	A	G	4: 43,930,936 (GRCm39)	N646D	probably damaging	Het
Rfx2	A	T	17: 57,093,736 (GRCm39)		probably benign	Het
Ripk2	G	A	4: 16,123,868 (GRCm39)	Q436*	probably null	Het
Ryr1	C	T	7: 28,704,992 (GRCm39)		probably benign	Het
Sema6b	A	G	17: 56,435,271 (GRCm39)	V324A	possibly damaging	Het
Sik2	C	A	9: 50,909,833 (GRCm39)	M73I	probably benign	Het
Slc39a6	T	C	18: 24,732,326 (GRCm39)	K321E	probably damaging	Het
Slc7a4	C	A	16: 17,391,875 (GRCm39)	V520F	probably benign	Het
Slitrk6	A	T	14: 110,987,364 (GRCm39)	L781H	probably damaging	Het
Spink14	T	C	18: 44,161,830 (GRCm39)	V2A	probably benign	Het
Sptan1	C	A	2: 29,893,679 (GRCm39)		probably benign	Het
Stab1	C	T	14: 30,879,027 (GRCm39)		probably benign	Het
Tbc1d17	C	T	7: 44,493,495 (GRCm39)		probably benign	Het
Tbcd	T	A	11: 121,394,590 (GRCm39)	L49*	probably null	Het
Tmco6	A	G	18: 36,875,160 (GRCm39)	T477A	probably benign	Het
Tmem208	C	T	8: 106,054,857 (GRCm39)	A53V	probably benign	Het
Tpp2	A	G	1: 44,020,908 (GRCm39)	T837A	possibly damaging	Het
Tulp4	A	T	17: 6,252,008 (GRCm39)	N60I	probably damaging	Het
Ubqlnl	A	T	7: 103,798,145 (GRCm39)	W451R	probably damaging	Het
Usp53	G	T	3: 122,746,956 (GRCm39)	C363*	probably null	Het
Usp7	A	T	16: 8,509,282 (GRCm39)	H1017Q	probably benign	Het
Utp4	A	G	8: 107,649,530 (GRCm39)	T660A	possibly damaging	Het
Vmn1r194	A	T	13: 22,428,641 (GRCm39)	Y86F	probably benign	Het
Vmn1r195	A	T	13: 22,463,409 (GRCm39)	H293L	possibly damaging	Het
Vmn1r231	T	C	17: 21,109,998 (GRCm39)	R306G	probably benign	Het
Vmn2r63	T	C	7: 42,576,514 (GRCm39)		probably benign	Het
Vmn2r77	T	C	7: 86,449,964 (GRCm39)	V70A	probably benign	Het
Vmn2r85	T	C	10: 130,261,770 (GRCm39)	D189G	probably damaging	Het
Vps8	A	G	16: 21,296,273 (GRCm39)	E515G	possibly damaging	Het
Wdr18	C	A	10: 79,796,937 (GRCm39)	Y104*	probably null	Het
Wnk4	A	T	11: 101,156,261 (GRCm39)	D43V	probably damaging	Het
Xab2	A	T	8: 3,663,880 (GRCm39)	N346K	probably damaging	Het
Xirp2	T	C	2: 67,342,484 (GRCm39)	V1575A	possibly damaging	Het
Zdhhc12	C	T	2: 29,982,547 (GRCm39)	R50H	probably damaging	Het
Zdhhc8	A	G	16: 18,043,064 (GRCm39)	S379P	probably benign	Het
Zfp458	G	A	13: 67,407,673 (GRCm39)	Q58*	probably null	Het
Zfp747	A	T	7: 126,973,772 (GRCm39)	S133T	probably benign	Het

Other mutations in Pkd1l3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Pkd1l3	APN	8	110,356,869 (GRCm39)	missense	possibly damaging	0.53
IGL00562:Pkd1l3	APN	8	110,382,779 (GRCm39)	missense	possibly damaging	0.53
IGL00563:Pkd1l3	APN	8	110,382,779 (GRCm39)	missense	possibly damaging	0.53
IGL01061:Pkd1l3	APN	8	110,365,338 (GRCm39)	missense	probably damaging	1.00
IGL01105:Pkd1l3	APN	8	110,388,873 (GRCm39)	missense	possibly damaging	0.81
IGL01574:Pkd1l3	APN	8	110,350,403 (GRCm39)	missense	probably benign	0.01
IGL01597:Pkd1l3	APN	8	110,350,153 (GRCm39)	missense	probably benign	0.33
IGL01634:Pkd1l3	APN	8	110,394,157 (GRCm39)	critical splice acceptor site	probably null
IGL01645:Pkd1l3	APN	8	110,361,934 (GRCm39)	missense	possibly damaging	0.59
IGL01770:Pkd1l3	APN	8	110,375,134 (GRCm39)	critical splice acceptor site	probably null
IGL01837:Pkd1l3	APN	8	110,356,798 (GRCm39)	missense	possibly damaging	0.85
IGL01862:Pkd1l3	APN	8	110,357,908 (GRCm39)	critical splice acceptor site	probably null
IGL01938:Pkd1l3	APN	8	110,361,933 (GRCm39)	missense	probably benign	0.00
IGL01990:Pkd1l3	APN	8	110,387,438 (GRCm39)	missense	probably damaging	1.00
IGL02056:Pkd1l3	APN	8	110,358,010 (GRCm39)	missense	probably benign	0.14
IGL02069:Pkd1l3	APN	8	110,362,012 (GRCm39)	missense	probably damaging	1.00
IGL02086:Pkd1l3	APN	8	110,392,217 (GRCm39)	missense	probably damaging	1.00
IGL02152:Pkd1l3	APN	8	110,395,924 (GRCm39)	missense	probably damaging	1.00
IGL02209:Pkd1l3	APN	8	110,365,296 (GRCm39)	missense	probably damaging	1.00
IGL02213:Pkd1l3	APN	8	110,357,977 (GRCm39)	missense	probably damaging	1.00
IGL02218:Pkd1l3	APN	8	110,387,434 (GRCm39)	missense	possibly damaging	0.92
IGL02225:Pkd1l3	APN	8	110,365,310 (GRCm39)	missense	probably damaging	1.00
IGL02252:Pkd1l3	APN	8	110,357,708 (GRCm39)	missense	possibly damaging	0.92
IGL02351:Pkd1l3	APN	8	110,373,129 (GRCm39)	unclassified	probably benign
IGL02358:Pkd1l3	APN	8	110,373,129 (GRCm39)	unclassified	probably benign
IGL02369:Pkd1l3	APN	8	110,342,977 (GRCm39)	missense	unknown
IGL02481:Pkd1l3	APN	8	110,341,414 (GRCm39)	missense	unknown
IGL02505:Pkd1l3	APN	8	110,359,848 (GRCm39)	missense	probably damaging	1.00
IGL02506:Pkd1l3	APN	8	110,374,132 (GRCm39)	missense	probably damaging	1.00
IGL02535:Pkd1l3	APN	8	110,367,522 (GRCm39)	nonsense	probably null
IGL02715:Pkd1l3	APN	8	110,353,458 (GRCm39)	missense	probably damaging	0.96
IGL02979:Pkd1l3	APN	8	110,388,736 (GRCm39)	splice site	probably benign
IGL03059:Pkd1l3	APN	8	110,374,999 (GRCm39)	missense	probably damaging	1.00
IGL03090:Pkd1l3	APN	8	110,382,165 (GRCm39)	nonsense	probably null
IGL03206:Pkd1l3	APN	8	110,350,345 (GRCm39)	missense	probably benign	0.18
IGL03328:Pkd1l3	APN	8	110,388,738 (GRCm39)	splice site	probably benign
BB006:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
PIT4453001:Pkd1l3	UTSW	8	110,387,433 (GRCm39)	missense	probably damaging	0.99
PIT4468001:Pkd1l3	UTSW	8	110,391,131 (GRCm39)	missense	possibly damaging	0.85
R0001:Pkd1l3	UTSW	8	110,355,265 (GRCm39)	splice site	probably benign
R0066:Pkd1l3	UTSW	8	110,347,103 (GRCm39)	missense	unknown
R0233:Pkd1l3	UTSW	8	110,377,412 (GRCm39)	nonsense	probably null
R0233:Pkd1l3	UTSW	8	110,377,412 (GRCm39)	nonsense	probably null
R0255:Pkd1l3	UTSW	8	110,365,386 (GRCm39)	missense	probably damaging	1.00
R0288:Pkd1l3	UTSW	8	110,373,131 (GRCm39)	splice site	probably null
R0311:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0311:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0403:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0403:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0441:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0446:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0465:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0465:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0466:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0467:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0468:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0488:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0488:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0515:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0534:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0650:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0689:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R1422:Pkd1l3	UTSW	8	110,348,340 (GRCm39)	missense	unknown
R1464:Pkd1l3	UTSW	8	110,363,059 (GRCm39)	splice site	probably benign
R1467:Pkd1l3	UTSW	8	110,343,000 (GRCm39)	missense	unknown
R1467:Pkd1l3	UTSW	8	110,343,000 (GRCm39)	missense	unknown
R1469:Pkd1l3	UTSW	8	110,373,585 (GRCm39)	missense	possibly damaging	0.72
R1469:Pkd1l3	UTSW	8	110,373,585 (GRCm39)	missense	possibly damaging	0.72
R1509:Pkd1l3	UTSW	8	110,367,402 (GRCm39)	missense	probably damaging	0.99
R1561:Pkd1l3	UTSW	8	110,341,445 (GRCm39)	missense	unknown
R1574:Pkd1l3	UTSW	8	110,341,445 (GRCm39)	missense	unknown
R1599:Pkd1l3	UTSW	8	110,363,016 (GRCm39)	missense	probably benign	0.01
R1688:Pkd1l3	UTSW	8	110,350,450 (GRCm39)	missense	probably benign	0.18
R1792:Pkd1l3	UTSW	8	110,359,237 (GRCm39)	missense	probably damaging	1.00
R1818:Pkd1l3	UTSW	8	110,375,038 (GRCm39)	missense	probably benign	0.03
R1896:Pkd1l3	UTSW	8	110,350,831 (GRCm39)	missense	possibly damaging	0.92
R2105:Pkd1l3	UTSW	8	110,374,205 (GRCm39)	nonsense	probably null
R2185:Pkd1l3	UTSW	8	110,359,827 (GRCm39)	missense	possibly damaging	0.95
R2192:Pkd1l3	UTSW	8	110,347,156 (GRCm39)	missense	unknown
R2260:Pkd1l3	UTSW	8	110,350,268 (GRCm39)	missense	probably benign	0.18
R2363:Pkd1l3	UTSW	8	110,355,341 (GRCm39)	missense	probably benign	0.01
R2418:Pkd1l3	UTSW	8	110,397,353 (GRCm39)	makesense	probably null
R2435:Pkd1l3	UTSW	8	110,377,334 (GRCm39)	missense	probably benign	0.07
R2443:Pkd1l3	UTSW	8	110,350,447 (GRCm39)	missense	probably benign	0.18
R2850:Pkd1l3	UTSW	8	110,350,622 (GRCm39)	missense	possibly damaging	0.92
R2910:Pkd1l3	UTSW	8	110,394,268 (GRCm39)	splice site	probably benign
R3755:Pkd1l3	UTSW	8	110,359,171 (GRCm39)	missense	probably damaging	1.00
R3791:Pkd1l3	UTSW	8	110,362,949 (GRCm39)	missense	probably damaging	0.99
R3905:Pkd1l3	UTSW	8	110,373,511 (GRCm39)	missense	probably benign	0.02
R4027:Pkd1l3	UTSW	8	110,350,603 (GRCm39)	missense	possibly damaging	0.68
R4028:Pkd1l3	UTSW	8	110,350,603 (GRCm39)	missense	possibly damaging	0.68
R4029:Pkd1l3	UTSW	8	110,350,603 (GRCm39)	missense	possibly damaging	0.68
R4274:Pkd1l3	UTSW	8	110,350,751 (GRCm39)	missense	possibly damaging	0.92
R4461:Pkd1l3	UTSW	8	110,359,345 (GRCm39)	splice site	probably null
R4893:Pkd1l3	UTSW	8	110,365,026 (GRCm39)	missense	probably benign	0.15
R4907:Pkd1l3	UTSW	8	110,367,475 (GRCm39)	missense	probably damaging	0.99
R5037:Pkd1l3	UTSW	8	110,392,268 (GRCm39)	missense	probably damaging	1.00
R5045:Pkd1l3	UTSW	8	110,349,787 (GRCm39)	missense	unknown
R5207:Pkd1l3	UTSW	8	110,359,823 (GRCm39)	missense	probably damaging	1.00
R5307:Pkd1l3	UTSW	8	110,367,424 (GRCm39)	missense	probably damaging	1.00
R5408:Pkd1l3	UTSW	8	110,393,684 (GRCm39)	missense	probably damaging	1.00
R5595:Pkd1l3	UTSW	8	110,382,152 (GRCm39)	missense	probably damaging	1.00
R5615:Pkd1l3	UTSW	8	110,356,842 (GRCm39)	missense	probably benign
R5623:Pkd1l3	UTSW	8	110,350,351 (GRCm39)	missense	possibly damaging	0.53
R5896:Pkd1l3	UTSW	8	110,353,468 (GRCm39)	missense	probably damaging	1.00
R6101:Pkd1l3	UTSW	8	110,367,478 (GRCm39)	missense	probably damaging	1.00
R6105:Pkd1l3	UTSW	8	110,367,478 (GRCm39)	missense	probably damaging	1.00
R6170:Pkd1l3	UTSW	8	110,349,811 (GRCm39)	missense	unknown
R6330:Pkd1l3	UTSW	8	110,373,541 (GRCm39)	missense	probably benign	0.00
R6346:Pkd1l3	UTSW	8	110,358,016 (GRCm39)	missense	probably damaging	0.98
R6395:Pkd1l3	UTSW	8	110,350,595 (GRCm39)	missense	probably benign	0.20
R6475:Pkd1l3	UTSW	8	110,349,844 (GRCm39)	missense	unknown
R6480:Pkd1l3	UTSW	8	110,365,019 (GRCm39)	nonsense	probably null
R6519:Pkd1l3	UTSW	8	110,355,404 (GRCm39)	missense	probably benign
R6654:Pkd1l3	UTSW	8	110,350,915 (GRCm39)	missense	probably benign	0.23
R6717:Pkd1l3	UTSW	8	110,341,401 (GRCm39)	missense	unknown
R6733:Pkd1l3	UTSW	8	110,375,126 (GRCm39)	splice site	probably null
R6753:Pkd1l3	UTSW	8	110,351,081 (GRCm39)	missense	probably damaging	1.00
R6777:Pkd1l3	UTSW	8	110,353,446 (GRCm39)	missense	probably benign	0.00
R6901:Pkd1l3	UTSW	8	110,341,246 (GRCm39)	missense	unknown
R6975:Pkd1l3	UTSW	8	110,387,539 (GRCm39)	missense	possibly damaging	0.73
R6991:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7018:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7083:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7139:Pkd1l3	UTSW	8	110,362,972 (GRCm39)	missense	probably damaging	0.96
R7153:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7235:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7238:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7252:Pkd1l3	UTSW	8	110,387,330 (GRCm39)	missense	probably benign	0.01
R7296:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7309:Pkd1l3	UTSW	8	110,374,893 (GRCm39)	splice site	probably null
R7362:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7462:Pkd1l3	UTSW	8	110,355,409 (GRCm39)	missense	probably benign	0.00
R7470:Pkd1l3	UTSW	8	110,365,008 (GRCm39)	missense	probably benign	0.09
R7478:Pkd1l3	UTSW	8	110,359,947 (GRCm39)	missense	probably damaging	1.00
R7483:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7516:Pkd1l3	UTSW	8	110,361,861 (GRCm39)	missense	probably damaging	1.00
R7553:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7559:Pkd1l3	UTSW	8	110,351,072 (GRCm39)	missense	probably benign	0.03
R7650:Pkd1l3	UTSW	8	110,399,217 (GRCm39)	missense	probably benign	0.23
R7654:Pkd1l3	UTSW	8	110,365,049 (GRCm39)	missense	probably damaging	1.00
R7742:Pkd1l3	UTSW	8	110,341,204 (GRCm39)	missense	unknown
R7749:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7751:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7755:Pkd1l3	UTSW	8	110,356,798 (GRCm39)	missense	possibly damaging	0.85
R7816:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7831:Pkd1l3	UTSW	8	110,357,990 (GRCm39)	missense	possibly damaging	0.47
R7835:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7849:Pkd1l3	UTSW	8	110,350,420 (GRCm39)	small deletion	probably benign
R7917:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7929:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7952:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8054:Pkd1l3	UTSW	8	110,373,008 (GRCm39)	missense	probably damaging	1.00
R8098:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8099:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8276:Pkd1l3	UTSW	8	110,397,353 (GRCm39)	makesense	probably null
R8352:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8376:Pkd1l3	UTSW	8	110,350,420 (GRCm39)	small deletion	probably benign
R8377:Pkd1l3	UTSW	8	110,361,982 (GRCm39)	missense	probably benign	0.08
R8398:Pkd1l3	UTSW	8	110,350,520 (GRCm39)	missense	possibly damaging	0.93
R8399:Pkd1l3	UTSW	8	110,350,520 (GRCm39)	missense	possibly damaging	0.93
R8400:Pkd1l3	UTSW	8	110,350,520 (GRCm39)	missense	possibly damaging	0.93
R8412:Pkd1l3	UTSW	8	110,360,022 (GRCm39)	missense	possibly damaging	0.85
R8530:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8539:Pkd1l3	UTSW	8	110,362,919 (GRCm39)	missense	probably damaging	1.00
R8546:Pkd1l3	UTSW	8	110,393,615 (GRCm39)	missense	possibly damaging	0.52
R8558:Pkd1l3	UTSW	8	110,362,012 (GRCm39)	missense	probably damaging	1.00
R8719:Pkd1l3	UTSW	8	110,341,255 (GRCm39)	missense	unknown
R8769:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8797:Pkd1l3	UTSW	8	110,374,946 (GRCm39)	missense	probably benign	0.15
R8840:Pkd1l3	UTSW	8	110,349,842 (GRCm39)	missense	unknown
R8846:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8874:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8893:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8956:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8963:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8968:Pkd1l3	UTSW	8	110,350,420 (GRCm39)	small deletion	probably benign
R9035:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9054:Pkd1l3	UTSW	8	110,392,304 (GRCm39)	missense	probably benign	0.08
R9058:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9119:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9134:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9138:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9158:Pkd1l3	UTSW	8	110,394,207 (GRCm39)	nonsense	probably null
R9180:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9181:Pkd1l3	UTSW	8	110,375,318 (GRCm39)	missense	probably damaging	0.98
R9218:Pkd1l3	UTSW	8	110,382,128 (GRCm39)	nonsense	probably null
R9249:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9269:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9338:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9383:Pkd1l3	UTSW	8	110,350,601 (GRCm39)	small deletion	probably benign
R9396:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9423:Pkd1l3	UTSW	8	110,350,312 (GRCm39)	missense	possibly damaging	0.53
R9514:Pkd1l3	UTSW	8	110,395,849 (GRCm39)	missense	probably damaging	1.00
R9515:Pkd1l3	UTSW	8	110,395,849 (GRCm39)	missense	probably damaging	1.00
R9567:Pkd1l3	UTSW	8	110,394,173 (GRCm39)	missense	probably damaging	0.99
R9668:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9684:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9748:Pkd1l3	UTSW	8	110,373,555 (GRCm39)	missense	probably benign	0.00
R9778:Pkd1l3	UTSW	8	110,357,937 (GRCm39)	missense	probably benign	0.00
RF016:Pkd1l3	UTSW	8	110,350,174 (GRCm39)	missense	probably benign	0.18
RF029:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
X0026:Pkd1l3	UTSW	8	110,341,185 (GRCm39)	missense	probably null
Z1176:Pkd1l3	UTSW	8	110,349,874 (GRCm39)	missense	unknown
Z31818:Pkd1l3	UTSW	8	110,395,924 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CGCCAAGGGAGATAATTTGCTCAGC -3'
(R):5'- AGGTTTGATAGCCAGCACCACG -3'

Sequencing Primer
(F):5'- GGAGATAATTTGCTCAGCATGTCC -3'
(R):5'- TACTCAGACACAAGTAGGTGCTTC -3'

Posted On

2013-05-23