Incidental Mutation 'IGL03151:Prss21'
ID 411087
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss21
Ensembl Gene ENSMUSG00000024116
Gene Name serine protease 21
Synonyms TESP5, mT4, 1700023E12Rik, testisin
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # IGL03151
Quality Score
Status
Chromosome 17
Chromosomal Location 24087046-24092087 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24088376 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 114 (T114A)
Ref Sequence ENSEMBL: ENSMUSP00000024928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024928]
AlphaFold Q9JHJ7
Predicted Effect probably damaging
Transcript: ENSMUST00000024928
AA Change: T114A

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000024928
Gene: ENSMUSG00000024116
AA Change: T114A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Tryp_SPc 54 291 1.18e-94 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for one knock-out allele impaires fertilization of epididymal sperm only in an in vitro experiment. Mice homozygous for another knock-out allele exhibit defective sperm maturation during passage through the epididymis and decreased spermfertilization capability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot1 G A 12: 84,061,326 (GRCm39) A211T probably damaging Het
Ampd1 T C 3: 102,999,786 (GRCm39) probably null Het
Armc3 T G 2: 19,243,509 (GRCm39) L75R probably damaging Het
Atp9b T C 18: 80,820,065 (GRCm39) D573G probably benign Het
Baz1a T A 12: 54,955,934 (GRCm39) probably null Het
C1ra A T 6: 124,496,730 (GRCm39) I389F probably benign Het
Ccdc87 T A 19: 4,891,585 (GRCm39) N692K probably benign Het
Ccr9 A G 9: 123,603,638 (GRCm39) probably benign Het
Ces4a G T 8: 105,874,829 (GRCm39) probably null Het
Dazap1 G A 10: 80,116,754 (GRCm39) probably benign Het
Dock5 A G 14: 68,103,516 (GRCm39) Y45H probably damaging Het
Eloa A T 4: 135,737,732 (GRCm39) Y409* probably null Het
Fam170a A G 18: 50,414,708 (GRCm39) E118G probably damaging Het
Fut2 C T 7: 45,300,193 (GRCm39) G193E possibly damaging Het
Glra1 C T 11: 55,418,206 (GRCm39) V180I probably damaging Het
Il17rb T C 14: 29,728,810 (GRCm39) T28A probably benign Het
Ints9 T A 14: 65,269,789 (GRCm39) V493E possibly damaging Het
Kcnq5 C T 1: 21,605,293 (GRCm39) C204Y probably damaging Het
Npc1 A T 18: 12,352,332 (GRCm39) N122K probably benign Het
Or2b4 G A 17: 38,116,159 (GRCm39) G41D probably damaging Het
Podnl1 G A 8: 84,858,818 (GRCm39) V548I probably benign Het
Prss59 A G 6: 40,902,946 (GRCm39) F142S probably damaging Het
Rab10 G A 12: 3,299,812 (GRCm39) T193M probably benign Het
Serpini1 T A 3: 75,520,603 (GRCm39) S67T probably benign Het
Slc35b1 T C 11: 95,281,212 (GRCm39) probably null Het
Sorbs2 A T 8: 46,252,750 (GRCm39) H388L probably benign Het
Tfap2c T A 2: 172,399,110 (GRCm39) C427* probably null Het
Trappc14 A G 5: 138,260,934 (GRCm39) L237S possibly damaging Het
Ttn G T 2: 76,632,732 (GRCm39) F14107L probably damaging Het
Upf1 G T 8: 70,788,037 (GRCm39) T774K probably damaging Het
Vmn1r170 G A 7: 23,306,002 (GRCm39) V135M probably benign Het
Vmn2r14 C T 5: 109,364,260 (GRCm39) C552Y probably damaging Het
Zfp367 A G 13: 64,293,445 (GRCm39) I147T probably damaging Het
Zfp952 T C 17: 33,221,982 (GRCm39) S116P probably benign Het
Other mutations in Prss21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01921:Prss21 APN 17 24,091,414 (GRCm39) missense possibly damaging 0.48
R1136:Prss21 UTSW 17 24,091,968 (GRCm39) missense probably damaging 1.00
R2299:Prss21 UTSW 17 24,088,563 (GRCm39) missense probably benign 0.18
R3615:Prss21 UTSW 17 24,091,805 (GRCm39) missense probably benign 0.20
R3616:Prss21 UTSW 17 24,091,805 (GRCm39) missense probably benign 0.20
R4589:Prss21 UTSW 17 24,091,796 (GRCm39) missense possibly damaging 0.96
R5691:Prss21 UTSW 17 24,087,759 (GRCm39) splice site probably null
R6946:Prss21 UTSW 17 24,087,138 (GRCm39) missense possibly damaging 0.92
R7835:Prss21 UTSW 17 24,088,425 (GRCm39) missense possibly damaging 0.57
R8243:Prss21 UTSW 17 24,088,376 (GRCm39) missense probably damaging 0.98
R8421:Prss21 UTSW 17 24,088,342 (GRCm39) missense possibly damaging 0.92
Posted On 2016-08-02