Incidental Mutation 'IGL03153:Tex33'
ID411155
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tex33
Ensembl Gene ENSMUSG00000062154
Gene Nametestis expressed 33
Synonyms1700061J05Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock #IGL03153
Quality Score
Status
Chromosome15
Chromosomal Location78378400-78395912 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 78385316 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 188 (D188G)
Ref Sequence ENSEMBL: ENSMUSP00000133264 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074380] [ENSMUST00000165170] [ENSMUST00000169575] [ENSMUST00000229878]
Predicted Effect probably damaging
Transcript: ENSMUST00000074380
AA Change: D188G

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000073984
Gene: ENSMUSG00000062154
AA Change: D188G

DomainStartEndE-ValueType
low complexity region 47 61 N/A INTRINSIC
low complexity region 63 71 N/A INTRINSIC
Pfam:TEX33 128 266 4.2e-73 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000165170
AA Change: D188G

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000133264
Gene: ENSMUSG00000062154
AA Change: D188G

DomainStartEndE-ValueType
low complexity region 47 61 N/A INTRINSIC
low complexity region 63 71 N/A INTRINSIC
Pfam:TEX33 128 265 1.7e-73 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000169575
AA Change: D163G

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000130849
Gene: ENSMUSG00000062154
AA Change: D163G

DomainStartEndE-ValueType
low complexity region 22 36 N/A INTRINSIC
low complexity region 38 46 N/A INTRINSIC
Pfam:TEX33 103 241 9.6e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000229878
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik A G 4: 62,547,326 E419G possibly damaging Het
Abcg3 A G 5: 104,974,765 probably benign Het
Adam17 T C 12: 21,345,697 D256G probably damaging Het
Adgrb3 G A 1: 25,531,897 R500* probably null Het
Aldh3a2 A G 11: 61,258,839 Y234H probably damaging Het
Alpk3 A G 7: 81,093,395 T987A probably benign Het
Amtn A G 5: 88,384,969 K148E possibly damaging Het
Asap1 G A 15: 64,160,274 T237M probably damaging Het
Ccdc124 A T 8: 70,868,929 probably null Het
Cdon T C 9: 35,477,959 Y787H probably damaging Het
Coro7 A G 16: 4,635,382 probably null Het
Dram2 T A 3: 106,555,174 probably benign Het
Drd5 T C 5: 38,319,781 V39A probably benign Het
Ern1 A G 11: 106,410,098 L490P possibly damaging Het
Fat1 A G 8: 45,030,123 T3083A possibly damaging Het
Irgm1 A G 11: 48,866,267 I239T probably damaging Het
Klhl10 A T 11: 100,456,932 T605S probably benign Het
Lcor T A 19: 41,558,356 S126R probably damaging Het
Lgi4 G T 7: 31,060,558 V60F probably damaging Het
Lin37 G A 7: 30,557,160 R84W probably damaging Het
Lmf1 A G 17: 25,585,650 S97G possibly damaging Het
Oasl2 A G 5: 114,901,332 T194A probably benign Het
Olfr199 A G 16: 59,216,203 S137P probably benign Het
Pnpo A T 11: 96,943,835 F12I probably damaging Het
Prdm4 T C 10: 85,907,996 T132A probably benign Het
Ptbp2 T C 3: 119,751,944 T118A probably benign Het
Ptf1a T A 2: 19,446,645 probably benign Het
Rev3l T A 10: 39,806,878 F331I probably damaging Het
Rfx6 C A 10: 51,723,121 S524* probably null Het
Scube3 A G 17: 28,167,058 S758G possibly damaging Het
Slc44a2 T C 9: 21,343,200 I257T probably benign Het
Spon1 A T 7: 114,030,344 I408F probably damaging Het
Srpk1 C A 17: 28,592,266 D541Y possibly damaging Het
Tenm4 A T 7: 96,873,762 I1467F probably damaging Het
Uggt1 A C 1: 36,202,818 V345G possibly damaging Het
Vmn1r23 A T 6: 57,925,932 I287K probably damaging Het
Whamm A G 7: 81,589,532 probably benign Het
Zeb1 A G 18: 5,770,511 D888G probably damaging Het
Zfp263 A G 16: 3,746,880 N253S possibly damaging Het
Zfp446 C A 7: 12,977,907 A19E probably benign Het
Other mutations in Tex33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00598:Tex33 APN 15 78386238 missense probably damaging 1.00
IGL02554:Tex33 APN 15 78378536 missense possibly damaging 0.92
R0201:Tex33 UTSW 15 78378828 missense probably damaging 0.96
R1557:Tex33 UTSW 15 78386274 missense probably damaging 0.99
R1828:Tex33 UTSW 15 78386388 missense possibly damaging 0.62
R1891:Tex33 UTSW 15 78378752 missense probably damaging 1.00
R5121:Tex33 UTSW 15 78386173 missense probably benign 0.40
R5438:Tex33 UTSW 15 78378840 missense possibly damaging 0.71
R6076:Tex33 UTSW 15 78386227 missense possibly damaging 0.66
R6156:Tex33 UTSW 15 78378813 missense probably damaging 1.00
R7105:Tex33 UTSW 15 78386118 missense possibly damaging 0.81
Posted On2016-08-02