Incidental Mutation 'IGL03154:Olfr739'
ID411180
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr739
Ensembl Gene ENSMUSG00000057903
Gene Nameolfactory receptor 739
SynonymsMOR106-2, GA_x6K02T2PMLR-6121675-6122604
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock #IGL03154
Quality Score
Status
Chromosome14
Chromosomal Location50418626-50427888 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 50424623 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 35 (I35F)
Ref Sequence ENSEMBL: ENSMUSP00000150559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075261] [ENSMUST00000216949]
Predicted Effect probably benign
Transcript: ENSMUST00000075261
AA Change: I35F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000074740
Gene: ENSMUSG00000057903
AA Change: I35F

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 1.1e-53 PFAM
Pfam:7tm_1 43 292 1.9e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216949
AA Change: I35F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a1 A G 19: 20,630,768 E318G probably benign Het
Alpi A T 1: 87,100,088 W257R probably damaging Het
Arap2 T C 5: 62,642,925 E1253G probably damaging Het
Fam208b A T 13: 3,575,255 M1565K possibly damaging Het
Fbxw13 G T 9: 109,181,465 F368L probably damaging Het
Gm7030 T A 17: 36,127,875 N208I probably benign Het
Herc2 T A 7: 56,202,159 D3655E probably damaging Het
Hkdc1 T A 10: 62,385,705 D858V probably damaging Het
Ifi205 A C 1: 174,017,666 probably benign Het
Ighv10-3 T A 12: 114,523,887 M1L probably benign Het
Igkv4-90 C T 6: 68,807,272 G87R probably damaging Het
Insc G A 7: 114,842,189 G413S probably null Het
Iqch T A 9: 63,454,682 T850S probably damaging Het
Kcnd2 A G 6: 21,216,708 Y137C probably damaging Het
Lhx6 A T 2: 36,094,443 probably null Het
Lrp2 A G 2: 69,549,042 S109P probably damaging Het
Mroh1 T C 15: 76,452,838 L1617P probably damaging Het
Olfr346 A T 2: 36,688,643 I214F possibly damaging Het
Olfr464 A T 11: 87,914,246 V220D possibly damaging Het
Olfr549 G T 7: 102,554,706 V141L probably benign Het
Prex2 T C 1: 11,153,633 V727A possibly damaging Het
Ralgapb A G 2: 158,432,866 H229R probably damaging Het
Rusc2 G A 4: 43,425,806 G1304S probably benign Het
Sbsn A G 7: 30,751,728 N56S possibly damaging Het
Skint8 T A 4: 111,939,510 probably null Het
Uso1 C A 5: 92,180,618 S358* probably null Het
Other mutations in Olfr739
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Olfr739 APN 14 50424561 missense possibly damaging 0.88
IGL02430:Olfr739 APN 14 50425151 missense probably benign
IGL02603:Olfr739 APN 14 50425200 missense probably damaging 1.00
IGL02959:Olfr739 APN 14 50424932 missense possibly damaging 0.76
R0455:Olfr739 UTSW 14 50424902 missense possibly damaging 0.45
R1984:Olfr739 UTSW 14 50425391 missense possibly damaging 0.93
R3160:Olfr739 UTSW 14 50425031 missense probably damaging 0.99
R3161:Olfr739 UTSW 14 50425031 missense probably damaging 0.99
R3162:Olfr739 UTSW 14 50425031 missense probably damaging 0.99
R4821:Olfr739 UTSW 14 50424749 missense possibly damaging 0.96
R4880:Olfr739 UTSW 14 50425301 missense possibly damaging 0.90
R5047:Olfr739 UTSW 14 50425239 missense probably damaging 1.00
R5384:Olfr739 UTSW 14 50425389 missense possibly damaging 0.77
R5385:Olfr739 UTSW 14 50425389 missense possibly damaging 0.77
R5386:Olfr739 UTSW 14 50425389 missense possibly damaging 0.77
R5640:Olfr739 UTSW 14 50424654 missense probably benign 0.18
R5809:Olfr739 UTSW 14 50425448 makesense probably null
R6035:Olfr739 UTSW 14 50424527 missense probably benign
R6035:Olfr739 UTSW 14 50424527 missense probably benign
R6229:Olfr739 UTSW 14 50425205 missense probably benign 0.38
R6614:Olfr739 UTSW 14 50425089 missense probably benign 0.00
Posted On2016-08-02