Incidental Mutation 'IGL03155:Vmn2r63'
| ID |
411214 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r63
|
| Ensembl Gene |
ENSMUSG00000090751 |
| Gene Name |
vomeronasal 2, receptor 63 |
| Synonyms |
EG435975 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
IGL03155
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
42552675-42583213 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 42552878 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 793
(V793I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163803]
|
| AlphaFold |
E9Q0K5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163803
AA Change: V793I
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: V793I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
3.5e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
3.5e-51 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adra1d |
C |
T |
2: 131,388,001 (GRCm39) |
R518H |
probably benign |
Het |
| Akr7a5 |
T |
A |
4: 139,041,837 (GRCm39) |
C190* |
probably null |
Het |
| Cct2 |
A |
T |
10: 116,896,576 (GRCm39) |
L209Q |
probably damaging |
Het |
| Chordc1 |
T |
A |
9: 18,215,616 (GRCm39) |
S123T |
possibly damaging |
Het |
| Crtap |
T |
C |
9: 114,209,117 (GRCm39) |
D309G |
possibly damaging |
Het |
| Csf2 |
T |
C |
11: 54,138,497 (GRCm39) |
T115A |
possibly damaging |
Het |
| Dgkb |
T |
A |
12: 38,189,458 (GRCm39) |
I287N |
probably damaging |
Het |
| Dyrk1b |
G |
A |
7: 27,882,112 (GRCm39) |
D98N |
probably benign |
Het |
| Eif4g1 |
T |
C |
16: 20,511,167 (GRCm39) |
S1550P |
probably damaging |
Het |
| Fam83e |
A |
G |
7: 45,376,499 (GRCm39) |
E404G |
possibly damaging |
Het |
| Fryl |
G |
A |
5: 73,234,038 (GRCm39) |
P1496S |
probably benign |
Het |
| Fsip1 |
A |
T |
2: 118,082,220 (GRCm39) |
N71K |
probably benign |
Het |
| Gm5092 |
A |
T |
17: 21,314,970 (GRCm39) |
|
noncoding transcript |
Het |
| Gnb1l |
T |
A |
16: 18,359,282 (GRCm39) |
|
probably null |
Het |
| Got1l1 |
T |
C |
8: 27,689,360 (GRCm39) |
Y233C |
probably damaging |
Het |
| Katnbl1 |
T |
A |
2: 112,239,577 (GRCm39) |
|
probably null |
Het |
| Kcnn2 |
A |
G |
18: 45,818,382 (GRCm39) |
E493G |
probably damaging |
Het |
| Kif26b |
C |
T |
1: 178,701,693 (GRCm39) |
R691W |
probably damaging |
Het |
| Lrp2 |
A |
T |
2: 69,285,796 (GRCm39) |
|
probably benign |
Het |
| Mast3 |
A |
G |
8: 71,241,861 (GRCm39) |
S107P |
probably damaging |
Het |
| Mrc1 |
A |
G |
2: 14,335,912 (GRCm39) |
N1433D |
probably benign |
Het |
| Mycbp2 |
G |
A |
14: 103,392,889 (GRCm39) |
S3114L |
probably benign |
Het |
| Naip6 |
T |
A |
13: 100,452,932 (GRCm39) |
H43L |
possibly damaging |
Het |
| Nin |
A |
T |
12: 70,078,544 (GRCm39) |
C1681S |
probably damaging |
Het |
| Nnmt |
C |
T |
9: 48,503,352 (GRCm39) |
V225M |
probably damaging |
Het |
| Or2ag1b |
A |
T |
7: 106,288,446 (GRCm39) |
M164K |
probably damaging |
Het |
| Or4c125 |
A |
T |
2: 89,170,310 (GRCm39) |
M112K |
probably damaging |
Het |
| Phf21a |
T |
G |
2: 92,150,611 (GRCm39) |
V64G |
probably damaging |
Het |
| Ptprd |
A |
T |
4: 75,984,456 (GRCm39) |
S800R |
possibly damaging |
Het |
| Scarf2 |
C |
T |
16: 17,625,413 (GRCm39) |
P823S |
probably benign |
Het |
| Scn5a |
T |
C |
9: 119,341,248 (GRCm39) |
T1212A |
possibly damaging |
Het |
| Slc38a10 |
C |
T |
11: 119,995,945 (GRCm39) |
V1043I |
probably damaging |
Het |
| Stxbp5 |
A |
T |
10: 9,692,034 (GRCm39) |
L370Q |
probably null |
Het |
| Tas1r2 |
T |
C |
4: 139,396,467 (GRCm39) |
V602A |
possibly damaging |
Het |
| Tatdn1 |
T |
C |
15: 58,788,045 (GRCm39) |
|
probably benign |
Het |
| Tdrd6 |
A |
T |
17: 43,936,398 (GRCm39) |
L1550Q |
probably damaging |
Het |
| Tet3 |
G |
T |
6: 83,345,365 (GRCm39) |
R1556S |
probably damaging |
Het |
| Tnpo2 |
T |
A |
8: 85,771,709 (GRCm39) |
I249N |
probably benign |
Het |
| Tnxb |
G |
T |
17: 34,932,569 (GRCm39) |
V2263F |
probably damaging |
Het |
| Trim75 |
C |
T |
8: 65,435,992 (GRCm39) |
V153M |
possibly damaging |
Het |
| Ttc21a |
T |
A |
9: 119,773,042 (GRCm39) |
|
probably null |
Het |
| Tuft1 |
T |
A |
3: 94,541,821 (GRCm39) |
I61L |
possibly damaging |
Het |
| Usp43 |
T |
C |
11: 67,767,315 (GRCm39) |
D680G |
probably damaging |
Het |
| Vac14 |
A |
G |
8: 111,362,975 (GRCm39) |
I274V |
possibly damaging |
Het |
| Vmn1r222 |
T |
A |
13: 23,416,863 (GRCm39) |
R117W |
probably damaging |
Het |
| Vmn1r83 |
T |
C |
7: 12,055,617 (GRCm39) |
M147V |
probably benign |
Het |
| Vmn2r43 |
T |
A |
7: 8,258,068 (GRCm39) |
I382L |
possibly damaging |
Het |
| Vopp1 |
A |
G |
6: 57,739,492 (GRCm39) |
Y19H |
possibly damaging |
Het |
| Yeats2 |
T |
C |
16: 20,048,323 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r63 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01399:Vmn2r63
|
APN |
7 |
42,553,543 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01765:Vmn2r63
|
APN |
7 |
42,552,788 (GRCm39) |
missense |
probably benign |
|
|
IGL02203:Vmn2r63
|
APN |
7 |
42,553,432 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02825:Vmn2r63
|
APN |
7 |
42,576,274 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03260:Vmn2r63
|
APN |
7 |
42,578,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03411:Vmn2r63
|
APN |
7 |
42,577,368 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4280001:Vmn2r63
|
UTSW |
7 |
42,553,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Vmn2r63
|
UTSW |
7 |
42,576,514 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r63
|
UTSW |
7 |
42,552,699 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0344:Vmn2r63
|
UTSW |
7 |
42,553,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0554:Vmn2r63
|
UTSW |
7 |
42,583,129 (GRCm39) |
nonsense |
probably null |
|
|
R0555:Vmn2r63
|
UTSW |
7 |
42,577,952 (GRCm39) |
nonsense |
probably null |
|
|
R0685:Vmn2r63
|
UTSW |
7 |
42,577,434 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0751:Vmn2r63
|
UTSW |
7 |
42,577,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1372:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1416:Vmn2r63
|
UTSW |
7 |
42,577,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Vmn2r63
|
UTSW |
7 |
42,578,015 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1563:Vmn2r63
|
UTSW |
7 |
42,553,550 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1652:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1693:Vmn2r63
|
UTSW |
7 |
42,577,743 (GRCm39) |
missense |
probably benign |
|
|
R1698:Vmn2r63
|
UTSW |
7 |
42,583,038 (GRCm39) |
missense |
probably benign |
|
|
R1753:Vmn2r63
|
UTSW |
7 |
42,577,669 (GRCm39) |
nonsense |
probably null |
|
|
R2136:Vmn2r63
|
UTSW |
7 |
42,576,297 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2175:Vmn2r63
|
UTSW |
7 |
42,583,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2261:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2262:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2263:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3413:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3426:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3427:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3802:Vmn2r63
|
UTSW |
7 |
42,552,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4319:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4321:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4323:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4346:Vmn2r63
|
UTSW |
7 |
42,577,537 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4568:Vmn2r63
|
UTSW |
7 |
42,583,250 (GRCm39) |
splice site |
probably null |
|
|
R4649:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4653:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4679:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4741:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4748:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4806:Vmn2r63
|
UTSW |
7 |
42,576,314 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4933:Vmn2r63
|
UTSW |
7 |
42,553,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5198:Vmn2r63
|
UTSW |
7 |
42,553,169 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5399:Vmn2r63
|
UTSW |
7 |
42,577,701 (GRCm39) |
missense |
probably benign |
|
|
R5400:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6158:Vmn2r63
|
UTSW |
7 |
42,583,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6185:Vmn2r63
|
UTSW |
7 |
42,578,435 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6267:Vmn2r63
|
UTSW |
7 |
42,578,059 (GRCm39) |
splice site |
probably null |
|
|
R6362:Vmn2r63
|
UTSW |
7 |
42,552,721 (GRCm39) |
missense |
probably benign |
|
|
R6706:Vmn2r63
|
UTSW |
7 |
42,578,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6764:Vmn2r63
|
UTSW |
7 |
42,552,695 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7104:Vmn2r63
|
UTSW |
7 |
42,577,959 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7503:Vmn2r63
|
UTSW |
7 |
42,583,014 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7506:Vmn2r63
|
UTSW |
7 |
42,576,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7658:Vmn2r63
|
UTSW |
7 |
42,574,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Vmn2r63
|
UTSW |
7 |
42,576,466 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7702:Vmn2r63
|
UTSW |
7 |
42,577,553 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7918:Vmn2r63
|
UTSW |
7 |
42,552,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8826:Vmn2r63
|
UTSW |
7 |
42,576,441 (GRCm39) |
missense |
probably benign |
0.38 |
|
R8973:Vmn2r63
|
UTSW |
7 |
42,577,919 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9024:Vmn2r63
|
UTSW |
7 |
42,577,874 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9154:Vmn2r63
|
UTSW |
7 |
42,576,413 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9731:Vmn2r63
|
UTSW |
7 |
42,553,361 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1088:Vmn2r63
|
UTSW |
7 |
42,577,983 (GRCm39) |
missense |
probably benign |
0.09 |
|
| Posted On |
2016-08-02 |
Incidental Mutation