Incidental Mutation 'IGL03160:Zfp87'
| ID |
411364 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp87
|
| Ensembl Gene |
ENSMUSG00000097333 |
| Gene Name |
zinc finger protein 87 |
| Synonyms |
Mzf22, 2210039O17Rik, 4631412O18Rik, Zfp72, KRAB4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.096)
|
| Stock # |
IGL03160
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
67663900-67674296 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 67669392 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 18
(E18G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138087
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167914]
[ENSMUST00000180536]
[ENSMUST00000181341]
[ENSMUST00000181573]
[ENSMUST00000181767]
|
| AlphaFold |
Q8K2A4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167914
AA Change: E18G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000137830
Gene: ENSMUSG00000097565
AA Change: E18G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
4.41e-34 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000180536
AA Change: E18G
PolyPhen 2
Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000137812
Gene: ENSMUSG00000097333
AA Change: E18G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
51 |
7.02e-19 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000181341
AA Change: E18G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000137689
Gene: ENSMUSG00000097333
AA Change: E18G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
4.41e-34 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000181573
AA Change: E18G
PolyPhen 2
Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000138011
Gene: ENSMUSG00000097333
AA Change: E18G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
51 |
7.02e-19 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000181767
AA Change: E18G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000138087
Gene: ENSMUSG00000097333
AA Change: E18G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
4.41e-34 |
SMART |
|
ZnF_C2H2
|
109 |
131 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
137 |
159 |
9.22e-5 |
SMART |
|
ZnF_C2H2
|
165 |
187 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
193 |
215 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
221 |
243 |
9.22e-5 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
445 |
467 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
472 |
494 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
4.47e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actbl2 |
T |
C |
13: 111,392,462 (GRCm39) |
S266P |
probably benign |
Het |
| Agrn |
A |
T |
4: 156,254,820 (GRCm39) |
F1525Y |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,380,165 (GRCm39) |
V2165A |
probably damaging |
Het |
| Ccn6 |
T |
C |
10: 39,029,233 (GRCm39) |
T232A |
probably damaging |
Het |
| Cd109 |
G |
T |
9: 78,568,338 (GRCm39) |
|
probably null |
Het |
| Cdhr4 |
A |
C |
9: 107,873,068 (GRCm39) |
T339P |
probably benign |
Het |
| Chek1 |
T |
C |
9: 36,633,941 (GRCm39) |
H128R |
probably damaging |
Het |
| Clcn7 |
T |
A |
17: 25,365,427 (GRCm39) |
|
probably benign |
Het |
| Dnah9 |
A |
G |
11: 65,998,880 (GRCm39) |
F1056S |
probably damaging |
Het |
| Eml3 |
A |
T |
19: 8,912,319 (GRCm39) |
Q372L |
probably benign |
Het |
| Fam161b |
T |
C |
12: 84,400,599 (GRCm39) |
T458A |
probably benign |
Het |
| Fbxo3 |
T |
A |
2: 103,860,692 (GRCm39) |
C36* |
probably null |
Het |
| Gm28042 |
T |
A |
2: 119,866,309 (GRCm39) |
I369N |
possibly damaging |
Het |
| Gpc1 |
A |
G |
1: 92,785,579 (GRCm39) |
Y423C |
probably damaging |
Het |
| Heatr5a |
A |
G |
12: 51,931,279 (GRCm39) |
|
probably benign |
Het |
| Hectd4 |
A |
T |
5: 121,397,942 (GRCm39) |
Y290F |
probably benign |
Het |
| Ifi207 |
T |
C |
1: 173,562,670 (GRCm39) |
|
probably benign |
Het |
| Kndc1 |
A |
T |
7: 139,500,605 (GRCm39) |
K657* |
probably null |
Het |
| Lama5 |
T |
C |
2: 179,822,128 (GRCm39) |
T2927A |
probably damaging |
Het |
| Lepr |
A |
T |
4: 101,622,103 (GRCm39) |
N345I |
probably damaging |
Het |
| Mtbp |
T |
C |
15: 55,484,013 (GRCm39) |
|
probably benign |
Het |
| Muc1 |
G |
A |
3: 89,140,331 (GRCm39) |
V608I |
possibly damaging |
Het |
| Or56a3 |
A |
G |
7: 104,735,520 (GRCm39) |
N199S |
probably damaging |
Het |
| P2ry13 |
A |
G |
3: 59,117,496 (GRCm39) |
L94P |
probably damaging |
Het |
| Retreg3 |
G |
T |
11: 100,990,501 (GRCm39) |
Q89K |
probably benign |
Het |
| Rhoq |
A |
C |
17: 87,304,349 (GRCm39) |
Y160S |
probably damaging |
Het |
| Samd9l |
A |
T |
6: 3,374,894 (GRCm39) |
V789D |
probably damaging |
Het |
| Slc35f5 |
T |
C |
1: 125,502,472 (GRCm39) |
S275P |
probably damaging |
Het |
| Slc51a |
G |
A |
16: 32,297,568 (GRCm39) |
R110C |
probably damaging |
Het |
| Snapc1 |
T |
A |
12: 74,016,978 (GRCm39) |
H205Q |
probably damaging |
Het |
| Stard3 |
G |
T |
11: 98,269,737 (GRCm39) |
R352L |
probably damaging |
Het |
| Stat5a |
A |
G |
11: 100,752,671 (GRCm39) |
I85V |
possibly damaging |
Het |
| Tenm3 |
A |
T |
8: 49,099,453 (GRCm39) |
D117E |
probably benign |
Het |
| Tg |
T |
A |
15: 66,711,152 (GRCm39) |
C971* |
probably null |
Het |
| Tnrc6c |
T |
A |
11: 117,640,651 (GRCm39) |
|
probably benign |
Het |
| Tra2a |
C |
T |
6: 49,240,798 (GRCm39) |
V4I |
possibly damaging |
Het |
| Trim54 |
C |
T |
5: 31,289,424 (GRCm39) |
T145I |
probably damaging |
Het |
| Vmn2r75 |
T |
C |
7: 85,797,644 (GRCm39) |
D723G |
probably damaging |
Het |
| Wnk1 |
T |
C |
6: 119,903,594 (GRCm39) |
T2042A |
probably damaging |
Het |
|
| Other mutations in Zfp87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02165:Zfp87
|
APN |
13 |
67,665,989 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02372:Zfp87
|
APN |
13 |
67,668,739 (GRCm39) |
splice site |
probably benign |
|
|
R0653:Zfp87
|
UTSW |
13 |
74,520,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0711:Zfp87
|
UTSW |
13 |
74,524,544 (GRCm39) |
splice site |
probably benign |
|
|
R1498:Zfp87
|
UTSW |
13 |
74,520,736 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3801:Zfp87
|
UTSW |
13 |
67,669,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4032:Zfp87
|
UTSW |
13 |
74,520,449 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4629:Zfp87
|
UTSW |
13 |
74,520,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4950:Zfp87
|
UTSW |
13 |
67,666,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5604:Zfp87
|
UTSW |
13 |
67,665,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6111:Zfp87
|
UTSW |
13 |
74,520,504 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6130:Zfp87
|
UTSW |
13 |
74,520,460 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R6277:Zfp87
|
UTSW |
13 |
74,520,643 (GRCm39) |
nonsense |
probably null |
|
|
R6392:Zfp87
|
UTSW |
13 |
67,664,986 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6800:Zfp87
|
UTSW |
13 |
74,520,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6909:Zfp87
|
UTSW |
13 |
74,519,861 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7009:Zfp87
|
UTSW |
13 |
67,665,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7183:Zfp87
|
UTSW |
13 |
67,665,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7298:Zfp87
|
UTSW |
13 |
74,520,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7330:Zfp87
|
UTSW |
13 |
74,523,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7341:Zfp87
|
UTSW |
13 |
74,520,467 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7448:Zfp87
|
UTSW |
13 |
67,665,163 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7597:Zfp87
|
UTSW |
13 |
67,665,412 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8696:Zfp87
|
UTSW |
13 |
74,520,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9280:Zfp87
|
UTSW |
13 |
74,520,803 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9429:Zfp87
|
UTSW |
13 |
74,520,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9780:Zfp87
|
UTSW |
13 |
67,665,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Zfp87
|
UTSW |
13 |
74,520,932 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF014:Zfp87
|
UTSW |
13 |
74,523,173 (GRCm39) |
missense |
probably benign |
0.17 |
|
Z1176:Zfp87
|
UTSW |
13 |
67,674,275 (GRCm39) |
start gained |
probably benign |
|
|
Z1177:Zfp87
|
UTSW |
13 |
74,519,911 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2016-08-02 |
Incidental Mutation