Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03162:Or10a3'

411462

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10a3

Ensembl Gene

ENSMUSG00000046431

Gene Name

olfactory receptor family 10 subfamily A member 3

Synonyms

Olfr518, MOR268-5, GA_x6K02T2PBJ9-11211854-11210853

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.165) question?

Stock #

IGL03162

Quality Score

Status

Chromosome

Chromosomal Location

108479810-108480811 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

T to C at 108480811 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 1 (M1V)

Ref Sequence

ENSEMBL: ENSMUSP00000151883 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059617] [ENSMUST00000217803]

AlphaFold

Q8VEW1

Predicted Effect

probably null
Transcript: ENSMUST00000059617
AA Change: M1V

SMART Domains

Protein: ENSMUSP00000050503
Gene: ENSMUSG00000046431
AA Change: M1V

Domain	Start	End	E-Value	Type
low complexity region	11	22	N/A	INTRINSIC
Pfam:7tm_4	50	327	7.1e-60	PFAM
Pfam:7tm_1	60	318	1.4e-23	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000217803
AA Change: M1V

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1bg	T	A	15: 60,791,581 (GRCm39)	D92V	probably damaging	Het
Acsl3	T	C	1: 78,676,887 (GRCm39)		probably null	Het
Adam5	T	C	8: 25,271,620 (GRCm39)	T596A	probably benign	Het
Adh6a	T	A	3: 138,034,880 (GRCm39)	Y336*	probably null	Het
Ak3	A	T	19: 29,000,236 (GRCm39)	V225D	possibly damaging	Het
Aldh1a7	T	A	19: 20,685,645 (GRCm39)	I302F	probably benign	Het
Amdhd1	T	C	10: 93,367,337 (GRCm39)		probably null	Het
Arhgef18	G	A	8: 3,491,301 (GRCm39)		probably null	Het
Caap1	A	T	4: 94,389,261 (GRCm39)		probably benign	Het
Cdhr4	G	A	9: 107,875,210 (GRCm39)	G70D	probably damaging	Het
Celsr3	T	C	9: 108,719,757 (GRCm39)	F2445S	probably damaging	Het
Cenpc1	A	G	5: 86,185,764 (GRCm39)	V249A	possibly damaging	Het
Clca3a2	C	A	3: 144,512,177 (GRCm39)	V80F	probably damaging	Het
Col6a1	T	A	10: 76,553,885 (GRCm39)		probably benign	Het
Commd10	T	A	18: 47,220,117 (GRCm39)	L198Q	probably damaging	Het
Cyp2d40	A	G	15: 82,644,243 (GRCm39)	L294P	unknown	Het
E2f6	T	A	12: 16,868,909 (GRCm39)	D77E	probably benign	Het
Elf5	T	A	2: 103,260,751 (GRCm39)	H38Q	possibly damaging	Het
Entrep1	T	G	19: 23,965,824 (GRCm39)	H225P	probably damaging	Het
Fcrl6	A	G	1: 172,425,820 (GRCm39)	V227A	probably damaging	Het
Fhip2b	G	T	14: 70,824,994 (GRCm39)	D447E	probably damaging	Het
Gabarapl2	T	A	8: 112,669,168 (GRCm39)	V42D	probably benign	Het
Gm3543	A	G	14: 41,802,022 (GRCm39)	I154T	possibly damaging	Het
Gpr150	T	A	13: 76,204,950 (GRCm39)		probably benign	Het
Gstp3	A	G	19: 4,109,255 (GRCm39)		probably benign	Het
Gzmm	C	T	10: 79,528,790 (GRCm39)	T64I	probably damaging	Het
Hs3st1	T	A	5: 39,771,792 (GRCm39)	K284*	probably null	Het
Ints7	A	G	1: 191,353,524 (GRCm39)		probably benign	Het
Itih2	A	T	2: 10,131,055 (GRCm39)	I94N	probably damaging	Het
Kif26b	A	G	1: 178,744,497 (GRCm39)	N1531S	probably benign	Het
Kif27	T	C	13: 58,459,021 (GRCm39)	S937G	probably benign	Het
Klhl2	A	G	8: 65,207,426 (GRCm39)	V311A	probably damaging	Het
Klrb1b	T	A	6: 128,795,892 (GRCm39)	Q109L	probably null	Het
Lrig2	A	G	3: 104,371,613 (GRCm39)	F697L	probably damaging	Het
Lrrc66	T	C	5: 73,764,725 (GRCm39)	R773G	probably benign	Het
Mrgpra2b	C	T	7: 47,113,815 (GRCm39)	V306I	probably benign	Het
Nipbl	T	C	15: 8,368,463 (GRCm39)	H1127R	probably benign	Het
Nr3c2	A	T	8: 77,944,213 (GRCm39)	D816V	probably damaging	Het
Ntmt2	T	A	1: 163,530,783 (GRCm39)	I219L	probably damaging	Het
Or5w19	A	C	2: 87,698,484 (GRCm39)	M50L	probably benign	Het
Pdxdc1	A	G	16: 13,675,281 (GRCm39)	L350P	probably damaging	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Pnpla7	T	C	2: 24,905,301 (GRCm39)		probably benign	Het
Ppan	T	G	9: 20,802,608 (GRCm39)	L283R	probably damaging	Het
Rbfox3	A	C	11: 118,387,257 (GRCm39)	S286A	probably benign	Het
Rbl2	A	G	8: 91,812,330 (GRCm39)	T273A	probably benign	Het
Recql4	G	T	15: 76,590,296 (GRCm39)		probably null	Het
Slc22a26	T	A	19: 7,779,466 (GRCm39)	M117L	probably benign	Het
Sult2a2	T	A	7: 13,468,822 (GRCm39)	I96K	probably damaging	Het
Tcf15	G	A	2: 151,990,626 (GRCm39)	R175H	probably benign	Het
Uggt1	A	T	1: 36,247,037 (GRCm39)	V320D	probably damaging	Het
Vmn2r102	A	G	17: 19,914,286 (GRCm39)	N617S	probably damaging	Het
Vpreb3	A	G	10: 75,785,133 (GRCm39)	Y77C	probably damaging	Het
Zbbx	A	T	3: 74,978,930 (GRCm39)		probably benign	Het
Zfand6	A	T	7: 84,283,185 (GRCm39)	S57R	probably benign	Het
Zmym2	A	G	14: 57,151,500 (GRCm39)	I462V	probably benign	Het

Other mutations in Or10a3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02713:Or10a3	APN	7	108,480,060 (GRCm39)	missense	probably damaging	0.99
IGL02995:Or10a3	APN	7	108,480,198 (GRCm39)	missense	probably damaging	1.00
IGL03389:Or10a3	APN	7	108,479,982 (GRCm39)	missense	probably damaging	0.99
R0731:Or10a3	UTSW	7	108,480,740 (GRCm39)	missense	probably damaging	1.00
R1669:Or10a3	UTSW	7	108,479,920 (GRCm39)	missense	probably benign	0.00
R2235:Or10a3	UTSW	7	108,480,172 (GRCm39)	missense	probably benign	0.09
R4740:Or10a3	UTSW	7	108,480,689 (GRCm39)	missense	probably benign	0.05
R4902:Or10a3	UTSW	7	108,480,624 (GRCm39)	missense	probably benign	0.00
R5343:Or10a3	UTSW	7	108,480,205 (GRCm39)	missense	possibly damaging	0.87
R6744:Or10a3	UTSW	7	108,480,037 (GRCm39)	missense	probably damaging	0.99
R7157:Or10a3	UTSW	7	108,480,475 (GRCm39)	missense	probably benign	0.03
R7326:Or10a3	UTSW	7	108,480,023 (GRCm39)	missense	probably damaging	1.00
R7713:Or10a3	UTSW	7	108,479,889 (GRCm39)	missense	probably damaging	1.00
R7819:Or10a3	UTSW	7	108,480,610 (GRCm39)	missense	probably damaging	0.99
R7939:Or10a3	UTSW	7	108,480,481 (GRCm39)	missense	probably benign	0.05
R8057:Or10a3	UTSW	7	108,480,571 (GRCm39)	missense	probably damaging	1.00
R8096:Or10a3	UTSW	7	108,480,248 (GRCm39)	nonsense	probably null
R8472:Or10a3	UTSW	7	108,479,973 (GRCm39)	missense	possibly damaging	0.95
R8766:Or10a3	UTSW	7	108,480,453 (GRCm39)	missense	probably benign	0.05
R9283:Or10a3	UTSW	7	108,480,289 (GRCm39)	missense	probably benign	0.03
R9570:Or10a3	UTSW	7	108,480,504 (GRCm39)	missense	possibly damaging	0.95
R9763:Or10a3	UTSW	7	108,480,874 (GRCm39)	start gained	probably benign
X0066:Or10a3	UTSW	7	108,480,679 (GRCm39)	missense	probably benign	0.00

Posted On

2016-08-02