Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03163:Vmn2r11'

411494

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r11

Ensembl Gene

ENSMUSG00000091450

Gene Name

vomeronasal 2, receptor 11

Synonyms

EG384219

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL03163

Quality Score

Status

Chromosome

Chromosomal Location

109194739-109207318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 109201692 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 271 (I271V)

Ref Sequence

ENSEMBL: ENSMUSP00000133218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164875]

AlphaFold

E9Q4X4

Predicted Effect

probably benign
Transcript: ENSMUST00000164875
AA Change: I271V

PolyPhen 2 Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: I271V

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	167	475	1.6e-29	PFAM
Pfam:NCD3G	520	574	9.1e-19	PFAM
Pfam:7tm_3	607	842	4.6e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn1	T	A	12: 80,228,191 (GRCm39)	D393V	probably benign	Het
Amz2	C	A	11: 109,319,751 (GRCm39)	Q46K	probably benign	Het
Ankhd1	G	A	18: 36,780,681 (GRCm39)	R1911H	probably damaging	Het
Apba3	A	G	10: 81,105,057 (GRCm39)		probably null	Het
Atxn1l	T	C	8: 110,459,017 (GRCm39)	N415S	probably damaging	Het
Clu	C	T	14: 66,217,235 (GRCm39)	S356F	probably benign	Het
Cluh	T	C	11: 74,556,894 (GRCm39)	V1029A	probably benign	Het
Creb3	C	T	4: 43,566,315 (GRCm39)	L274F	probably damaging	Het
Dcaf8	T	C	1: 172,000,475 (GRCm39)	V211A	probably damaging	Het
Emilin3	G	A	2: 160,750,649 (GRCm39)	Q320*	probably null	Het
Fam131c	T	C	4: 141,110,069 (GRCm39)	F156L	probably damaging	Het
Fbxw21	T	A	9: 108,974,552 (GRCm39)	I323F	probably benign	Het
Fmo9	A	G	1: 166,502,019 (GRCm39)	V202A	possibly damaging	Het
Gipr	C	T	7: 18,896,481 (GRCm39)	W205*	probably null	Het
Gm13941	A	T	2: 110,928,761 (GRCm39)	I99K	unknown	Het
Gpr22	A	T	12: 31,759,171 (GRCm39)	V317E	possibly damaging	Het
Hace1	T	C	10: 45,548,701 (GRCm39)	I582T	probably damaging	Het
Iho1	G	T	9: 108,282,132 (GRCm39)	L519I	probably benign	Het
Khdrbs1	T	C	4: 129,619,508 (GRCm39)	E211G	probably benign	Het
Lonrf1	T	C	8: 36,697,484 (GRCm39)	D500G	probably benign	Het
Lrp2	A	C	2: 69,331,870 (GRCm39)	Y1628*	probably null	Het
Lrrc40	T	C	3: 157,747,224 (GRCm39)	I112T	possibly damaging	Het
Matr3	G	A	18: 35,705,644 (GRCm39)	D190N	probably damaging	Het
Or8c16	T	C	9: 38,130,710 (GRCm39)	V194A	probably benign	Het
Ptpn13	A	T	5: 103,739,212 (GRCm39)	D2326V	probably damaging	Het
Ptpn3	T	C	4: 57,222,020 (GRCm39)	D557G	probably damaging	Het
Rangap1	A	T	15: 81,600,801 (GRCm39)	N194K	probably damaging	Het
Rasgef1c	T	C	11: 49,862,200 (GRCm39)	V363A	possibly damaging	Het
Ric8b	A	G	10: 84,837,686 (GRCm39)	N498D	probably damaging	Het
Scn1a	A	C	2: 66,148,418 (GRCm39)	D22E	probably benign	Het
Spc25	T	G	2: 69,027,548 (GRCm39)	I115L	probably damaging	Het
Sspo	A	G	6: 48,461,266 (GRCm39)	H3569R	probably benign	Het
Stra6l	T	C	4: 45,881,455 (GRCm39)	I439T	probably benign	Het
Trappc12	G	T	12: 28,796,653 (GRCm39)	P293Q	probably damaging	Het
Trcg1	T	C	9: 57,155,630 (GRCm39)	L761P	possibly damaging	Het
Usp15	A	C	10: 123,007,049 (GRCm39)	M144R	probably damaging	Het
Zcchc2	T	C	1: 105,958,841 (GRCm39)	V1104A	probably damaging	Het
Zftraf1	A	T	15: 76,543,474 (GRCm39)	L13Q	probably damaging	Het

Other mutations in Vmn2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Vmn2r11	APN	5	109,194,885 (GRCm39)	missense	probably benign	0.00
IGL01677:Vmn2r11	APN	5	109,201,823 (GRCm39)	missense	possibly damaging	0.50
IGL02048:Vmn2r11	APN	5	109,202,658 (GRCm39)	missense	probably benign	0.00
IGL02559:Vmn2r11	APN	5	109,200,046 (GRCm39)	missense	probably damaging	0.98
IGL02879:Vmn2r11	APN	5	109,201,704 (GRCm39)	missense	possibly damaging	0.95
IGL03084:Vmn2r11	APN	5	109,207,209 (GRCm39)	missense	probably benign	0.00
IGL03289:Vmn2r11	APN	5	109,196,788 (GRCm39)	splice site	probably benign
IGL03294:Vmn2r11	APN	5	109,201,935 (GRCm39)	missense	probably benign	0.22
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0421:Vmn2r11	UTSW	5	109,207,294 (GRCm39)	missense	probably benign	0.00
R0549:Vmn2r11	UTSW	5	109,199,963 (GRCm39)	missense	possibly damaging	0.80
R0628:Vmn2r11	UTSW	5	109,195,597 (GRCm39)	missense	possibly damaging	0.88
R1523:Vmn2r11	UTSW	5	109,201,707 (GRCm39)	missense	probably benign	0.25
R1660:Vmn2r11	UTSW	5	109,201,724 (GRCm39)	missense	possibly damaging	0.79
R1827:Vmn2r11	UTSW	5	109,199,938 (GRCm39)	missense	probably benign	0.01
R1913:Vmn2r11	UTSW	5	109,202,654 (GRCm39)	missense	probably benign
R2260:Vmn2r11	UTSW	5	109,201,657 (GRCm39)	nonsense	probably null
R2400:Vmn2r11	UTSW	5	109,199,928 (GRCm39)	missense	probably benign	0.03
R3933:Vmn2r11	UTSW	5	109,201,260 (GRCm39)	missense	probably damaging	0.97
R4091:Vmn2r11	UTSW	5	109,202,616 (GRCm39)	critical splice donor site	probably null
R4624:Vmn2r11	UTSW	5	109,200,101 (GRCm39)	missense	probably damaging	0.99
R4762:Vmn2r11	UTSW	5	109,195,436 (GRCm39)	missense	probably damaging	1.00
R5256:Vmn2r11	UTSW	5	109,202,658 (GRCm39)	missense	probably benign	0.26
R5370:Vmn2r11	UTSW	5	109,195,421 (GRCm39)	missense	probably damaging	1.00
R5419:Vmn2r11	UTSW	5	109,207,224 (GRCm39)	missense	possibly damaging	0.55
R5516:Vmn2r11	UTSW	5	109,195,032 (GRCm39)	missense	probably damaging	0.98
R5643:Vmn2r11	UTSW	5	109,194,869 (GRCm39)	missense	probably damaging	1.00
R5671:Vmn2r11	UTSW	5	109,202,772 (GRCm39)	missense	probably benign	0.03
R5679:Vmn2r11	UTSW	5	109,202,708 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r11	UTSW	5	109,207,114 (GRCm39)	critical splice donor site	probably null
R5746:Vmn2r11	UTSW	5	109,201,560 (GRCm39)	missense	probably benign	0.41
R5995:Vmn2r11	UTSW	5	109,194,921 (GRCm39)	missense	probably damaging	1.00
R6147:Vmn2r11	UTSW	5	109,202,700 (GRCm39)	missense	probably benign	0.04
R6220:Vmn2r11	UTSW	5	109,201,434 (GRCm39)	missense	probably benign	0.09
R6374:Vmn2r11	UTSW	5	109,201,679 (GRCm39)	missense	possibly damaging	0.65
R6491:Vmn2r11	UTSW	5	109,196,800 (GRCm39)	missense	possibly damaging	0.95
R6804:Vmn2r11	UTSW	5	109,201,350 (GRCm39)	missense	probably damaging	1.00
R6814:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R6872:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R7014:Vmn2r11	UTSW	5	109,201,289 (GRCm39)	missense	probably damaging	1.00
R7041:Vmn2r11	UTSW	5	109,202,816 (GRCm39)	missense	probably damaging	1.00
R7043:Vmn2r11	UTSW	5	109,200,098 (GRCm39)	missense	probably benign	0.00
R7050:Vmn2r11	UTSW	5	109,202,657 (GRCm39)	missense	probably benign	0.05
R7184:Vmn2r11	UTSW	5	109,201,281 (GRCm39)	missense	probably damaging	1.00
R7388:Vmn2r11	UTSW	5	109,202,742 (GRCm39)	missense	probably benign	0.05
R7477:Vmn2r11	UTSW	5	109,207,214 (GRCm39)	missense	possibly damaging	0.67
R7524:Vmn2r11	UTSW	5	109,201,848 (GRCm39)	missense	probably benign	0.01
R7682:Vmn2r11	UTSW	5	109,195,481 (GRCm39)	missense	probably benign	0.02
R7715:Vmn2r11	UTSW	5	109,195,307 (GRCm39)	missense	probably damaging	0.99
R7869:Vmn2r11	UTSW	5	109,199,986 (GRCm39)	missense	probably damaging	1.00
R8094:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8277:Vmn2r11	UTSW	5	109,202,833 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r11	UTSW	5	109,207,270 (GRCm39)	missense	probably benign	0.00
R8676:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8701:Vmn2r11	UTSW	5	109,195,556 (GRCm39)	missense	probably damaging	1.00
R8749:Vmn2r11	UTSW	5	109,195,319 (GRCm39)	missense	probably damaging	0.97
R9046:Vmn2r11	UTSW	5	109,202,850 (GRCm39)	missense	probably benign	0.00
R9138:Vmn2r11	UTSW	5	109,201,904 (GRCm39)	missense	probably damaging	1.00
R9267:Vmn2r11	UTSW	5	109,199,929 (GRCm39)	missense	possibly damaging	0.93
R9306:Vmn2r11	UTSW	5	109,196,831 (GRCm39)	missense	probably damaging	1.00
R9384:Vmn2r11	UTSW	5	109,201,266 (GRCm39)	missense	probably damaging	1.00
R9443:Vmn2r11	UTSW	5	109,195,159 (GRCm39)	nonsense	probably null
R9520:Vmn2r11	UTSW	5	109,201,455 (GRCm39)	missense	probably benign	0.35
R9596:Vmn2r11	UTSW	5	109,201,563 (GRCm39)	missense	possibly damaging	0.67
R9677:Vmn2r11	UTSW	5	109,201,332 (GRCm39)	missense

Posted On

2016-08-02