Incidental Mutation 'IGL03163:Fmo9'
| ID |
411524 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fmo9
|
| Ensembl Gene |
ENSMUSG00000026560 |
| Gene Name |
flavin containing monooxygenase 9 |
| Synonyms |
4831428F09Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.064)
|
| Stock # |
IGL03163
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
166489624-166509414 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 166502019 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 202
(V202A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000027843
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027843]
[ENSMUST00000148677]
|
| AlphaFold |
Q8C116 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000027843
AA Change: V202A
PolyPhen 2
Score 0.772 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000027843
Gene: ENSMUSG00000026560
AA Change: V202A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FMO-like
|
3 |
535 |
1.2e-252 |
PFAM |
|
Pfam:Pyr_redox_2
|
4 |
262 |
2.9e-12 |
PFAM |
|
Pfam:Pyr_redox_3
|
7 |
221 |
2.3e-14 |
PFAM |
|
Pfam:NAD_binding_8
|
8 |
83 |
1.2e-6 |
PFAM |
|
Pfam:K_oxygenase
|
77 |
334 |
8.9e-11 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000148677
AA Change: V151A
PolyPhen 2
Score 0.733 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000114750
Gene: ENSMUSG00000026560
AA Change: V151A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FMO-like
|
1 |
484 |
1.6e-222 |
PFAM |
|
Pfam:Pyr_redox_3
|
3 |
170 |
1.2e-12 |
PFAM |
|
Pfam:K_oxygenase
|
28 |
283 |
6.2e-11 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actn1 |
T |
A |
12: 80,228,191 (GRCm39) |
D393V |
probably benign |
Het |
| Amz2 |
C |
A |
11: 109,319,751 (GRCm39) |
Q46K |
probably benign |
Het |
| Ankhd1 |
G |
A |
18: 36,780,681 (GRCm39) |
R1911H |
probably damaging |
Het |
| Apba3 |
A |
G |
10: 81,105,057 (GRCm39) |
|
probably null |
Het |
| Atxn1l |
T |
C |
8: 110,459,017 (GRCm39) |
N415S |
probably damaging |
Het |
| Clu |
C |
T |
14: 66,217,235 (GRCm39) |
S356F |
probably benign |
Het |
| Cluh |
T |
C |
11: 74,556,894 (GRCm39) |
V1029A |
probably benign |
Het |
| Creb3 |
C |
T |
4: 43,566,315 (GRCm39) |
L274F |
probably damaging |
Het |
| Dcaf8 |
T |
C |
1: 172,000,475 (GRCm39) |
V211A |
probably damaging |
Het |
| Emilin3 |
G |
A |
2: 160,750,649 (GRCm39) |
Q320* |
probably null |
Het |
| Fam131c |
T |
C |
4: 141,110,069 (GRCm39) |
F156L |
probably damaging |
Het |
| Fbxw21 |
T |
A |
9: 108,974,552 (GRCm39) |
I323F |
probably benign |
Het |
| Gipr |
C |
T |
7: 18,896,481 (GRCm39) |
W205* |
probably null |
Het |
| Gm13941 |
A |
T |
2: 110,928,761 (GRCm39) |
I99K |
unknown |
Het |
| Gpr22 |
A |
T |
12: 31,759,171 (GRCm39) |
V317E |
possibly damaging |
Het |
| Hace1 |
T |
C |
10: 45,548,701 (GRCm39) |
I582T |
probably damaging |
Het |
| Iho1 |
G |
T |
9: 108,282,132 (GRCm39) |
L519I |
probably benign |
Het |
| Khdrbs1 |
T |
C |
4: 129,619,508 (GRCm39) |
E211G |
probably benign |
Het |
| Lonrf1 |
T |
C |
8: 36,697,484 (GRCm39) |
D500G |
probably benign |
Het |
| Lrp2 |
A |
C |
2: 69,331,870 (GRCm39) |
Y1628* |
probably null |
Het |
| Lrrc40 |
T |
C |
3: 157,747,224 (GRCm39) |
I112T |
possibly damaging |
Het |
| Matr3 |
G |
A |
18: 35,705,644 (GRCm39) |
D190N |
probably damaging |
Het |
| Or8c16 |
T |
C |
9: 38,130,710 (GRCm39) |
V194A |
probably benign |
Het |
| Ptpn13 |
A |
T |
5: 103,739,212 (GRCm39) |
D2326V |
probably damaging |
Het |
| Ptpn3 |
T |
C |
4: 57,222,020 (GRCm39) |
D557G |
probably damaging |
Het |
| Rangap1 |
A |
T |
15: 81,600,801 (GRCm39) |
N194K |
probably damaging |
Het |
| Rasgef1c |
T |
C |
11: 49,862,200 (GRCm39) |
V363A |
possibly damaging |
Het |
| Ric8b |
A |
G |
10: 84,837,686 (GRCm39) |
N498D |
probably damaging |
Het |
| Scn1a |
A |
C |
2: 66,148,418 (GRCm39) |
D22E |
probably benign |
Het |
| Spc25 |
T |
G |
2: 69,027,548 (GRCm39) |
I115L |
probably damaging |
Het |
| Sspo |
A |
G |
6: 48,461,266 (GRCm39) |
H3569R |
probably benign |
Het |
| Stra6l |
T |
C |
4: 45,881,455 (GRCm39) |
I439T |
probably benign |
Het |
| Trappc12 |
G |
T |
12: 28,796,653 (GRCm39) |
P293Q |
probably damaging |
Het |
| Trcg1 |
T |
C |
9: 57,155,630 (GRCm39) |
L761P |
possibly damaging |
Het |
| Usp15 |
A |
C |
10: 123,007,049 (GRCm39) |
M144R |
probably damaging |
Het |
| Vmn2r11 |
T |
C |
5: 109,201,692 (GRCm39) |
I271V |
probably benign |
Het |
| Zcchc2 |
T |
C |
1: 105,958,841 (GRCm39) |
V1104A |
probably damaging |
Het |
| Zftraf1 |
A |
T |
15: 76,543,474 (GRCm39) |
L13Q |
probably damaging |
Het |
|
| Other mutations in Fmo9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00886:Fmo9
|
APN |
1 |
166,507,714 (GRCm39) |
splice site |
probably null |
|
|
IGL01796:Fmo9
|
APN |
1 |
166,490,904 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL03005:Fmo9
|
APN |
1 |
166,502,088 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03115:Fmo9
|
APN |
1 |
166,505,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0089:Fmo9
|
UTSW |
1 |
166,494,878 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0570:Fmo9
|
UTSW |
1 |
166,502,031 (GRCm39) |
missense |
probably null |
0.00 |
|
R1520:Fmo9
|
UTSW |
1 |
166,495,024 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1779:Fmo9
|
UTSW |
1 |
166,490,868 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1783:Fmo9
|
UTSW |
1 |
166,501,217 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2858:Fmo9
|
UTSW |
1 |
166,501,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2859:Fmo9
|
UTSW |
1 |
166,501,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3851:Fmo9
|
UTSW |
1 |
166,490,936 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3924:Fmo9
|
UTSW |
1 |
166,492,221 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4470:Fmo9
|
UTSW |
1 |
166,507,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4728:Fmo9
|
UTSW |
1 |
166,490,880 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5538:Fmo9
|
UTSW |
1 |
166,501,198 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5650:Fmo9
|
UTSW |
1 |
166,491,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5820:Fmo9
|
UTSW |
1 |
166,492,170 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6163:Fmo9
|
UTSW |
1 |
166,494,962 (GRCm39) |
missense |
probably benign |
|
|
R6229:Fmo9
|
UTSW |
1 |
166,505,126 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6243:Fmo9
|
UTSW |
1 |
166,494,938 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6375:Fmo9
|
UTSW |
1 |
166,492,164 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7144:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7236:Fmo9
|
UTSW |
1 |
166,504,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Fmo9
|
UTSW |
1 |
166,491,215 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7341:Fmo9
|
UTSW |
1 |
166,504,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7382:Fmo9
|
UTSW |
1 |
166,491,229 (GRCm39) |
splice site |
probably null |
|
|
R7589:Fmo9
|
UTSW |
1 |
166,501,997 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7679:Fmo9
|
UTSW |
1 |
166,495,058 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8110:Fmo9
|
UTSW |
1 |
166,491,095 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8500:Fmo9
|
UTSW |
1 |
166,502,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9098:Fmo9
|
UTSW |
1 |
166,492,199 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9301:Fmo9
|
UTSW |
1 |
166,494,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9400:Fmo9
|
UTSW |
1 |
166,505,243 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9401:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Fmo9
|
UTSW |
1 |
166,501,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation