Incidental Mutation 'IGL03165:Cyp2g1'
| ID |
411601 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cyp2g1
|
| Ensembl Gene |
ENSMUSG00000049685 |
| Gene Name |
cytochrome P450, family 2, subfamily g, polypeptide 1 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03165
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
26508352-26520622 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 26509201 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 92
(V92M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047150
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040944]
|
| AlphaFold |
Q9WV19 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000040944
AA Change: V92M
PolyPhen 2
Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000047150
Gene: ENSMUSG00000049685
AA Change: V92M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
12 |
23 |
N/A |
INTRINSIC |
|
Pfam:p450
|
34 |
491 |
4e-150 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb3 |
T |
C |
1: 25,133,475 (GRCm39) |
I334V |
probably benign |
Het |
| Axdnd1 |
T |
A |
1: 156,205,959 (GRCm39) |
Y519F |
probably benign |
Het |
| C4b |
A |
G |
17: 34,958,929 (GRCm39) |
F500S |
probably benign |
Het |
| Cacng2 |
A |
T |
15: 77,879,863 (GRCm39) |
I153N |
possibly damaging |
Het |
| Ces1d |
T |
A |
8: 93,916,147 (GRCm39) |
H160L |
probably benign |
Het |
| Cnnm3 |
T |
G |
1: 36,564,313 (GRCm39) |
|
probably benign |
Het |
| Ctnna3 |
A |
G |
10: 64,781,720 (GRCm39) |
T728A |
probably damaging |
Het |
| Dock2 |
C |
A |
11: 34,578,360 (GRCm39) |
V35F |
probably damaging |
Het |
| Eif2a |
C |
A |
3: 58,456,049 (GRCm39) |
Y349* |
probably null |
Het |
| Erp44 |
C |
T |
4: 48,236,872 (GRCm39) |
|
probably null |
Het |
| Flg2 |
C |
T |
3: 93,121,918 (GRCm39) |
H1363Y |
unknown |
Het |
| Flnc |
G |
T |
6: 29,449,377 (GRCm39) |
G1425W |
probably damaging |
Het |
| Frem3 |
A |
G |
8: 81,339,158 (GRCm39) |
N484D |
probably benign |
Het |
| Fstl3 |
A |
G |
10: 79,615,799 (GRCm39) |
D95G |
probably benign |
Het |
| Gldc |
A |
G |
19: 30,076,393 (GRCm39) |
S1018P |
possibly damaging |
Het |
| Gstk1 |
T |
G |
6: 42,226,368 (GRCm39) |
I159S |
probably benign |
Het |
| Herc2 |
A |
G |
7: 55,841,660 (GRCm39) |
E3513G |
probably damaging |
Het |
| Hpca |
A |
T |
4: 129,012,383 (GRCm39) |
I51N |
probably damaging |
Het |
| Hsd17b7 |
C |
T |
1: 169,780,649 (GRCm39) |
E320K |
probably damaging |
Het |
| Igkv4-74 |
T |
C |
6: 69,162,289 (GRCm39) |
|
probably benign |
Het |
| Kdm7a |
C |
A |
6: 39,147,848 (GRCm39) |
|
probably benign |
Het |
| Or1e23 |
A |
T |
11: 73,407,710 (GRCm39) |
L105* |
probably null |
Het |
| Or52z14 |
T |
C |
7: 103,253,218 (GRCm39) |
I119T |
probably damaging |
Het |
| Or5al6 |
A |
C |
2: 85,976,412 (GRCm39) |
L222R |
possibly damaging |
Het |
| Pa2g4 |
A |
T |
10: 128,394,929 (GRCm39) |
|
probably null |
Het |
| Pdlim3 |
T |
A |
8: 46,372,035 (GRCm39) |
L360Q |
possibly damaging |
Het |
| Pkd1l2 |
G |
A |
8: 117,792,484 (GRCm39) |
T436I |
probably benign |
Het |
| Polk |
T |
A |
13: 96,653,196 (GRCm39) |
Q68L |
probably benign |
Het |
| Ppfia2 |
T |
G |
10: 106,603,348 (GRCm39) |
L195R |
probably damaging |
Het |
| Ranbp1 |
A |
T |
16: 18,065,145 (GRCm39) |
|
probably benign |
Het |
| Rbm12b1 |
A |
G |
4: 12,145,845 (GRCm39) |
R606G |
possibly damaging |
Het |
| Ryr1 |
A |
G |
7: 28,804,465 (GRCm39) |
V488A |
probably benign |
Het |
| Sall2 |
A |
T |
14: 52,551,625 (GRCm39) |
D521E |
probably damaging |
Het |
| Sntg1 |
A |
T |
1: 8,515,328 (GRCm39) |
C402S |
probably damaging |
Het |
| Spg7 |
T |
C |
8: 123,807,551 (GRCm39) |
|
probably null |
Het |
| Stk31 |
G |
A |
6: 49,422,198 (GRCm39) |
E750K |
probably damaging |
Het |
| Tlr2 |
A |
G |
3: 83,745,255 (GRCm39) |
I276T |
probably benign |
Het |
| Trav12-2 |
A |
T |
14: 53,854,206 (GRCm39) |
H60L |
probably benign |
Het |
| Urb1 |
A |
G |
16: 90,577,192 (GRCm39) |
L775S |
probably damaging |
Het |
| Utp14b |
A |
G |
1: 78,642,237 (GRCm39) |
D45G |
probably damaging |
Het |
|
| Other mutations in Cyp2g1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01134:Cyp2g1
|
APN |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01137:Cyp2g1
|
APN |
7 |
26,513,684 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02052:Cyp2g1
|
APN |
7 |
26,513,719 (GRCm39) |
splice site |
probably benign |
|
|
IGL02338:Cyp2g1
|
APN |
7 |
26,514,229 (GRCm39) |
splice site |
probably benign |
|
|
IGL02452:Cyp2g1
|
APN |
7 |
26,510,871 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02523:Cyp2g1
|
APN |
7 |
26,518,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03230:Cyp2g1
|
APN |
7 |
26,518,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4472001:Cyp2g1
|
UTSW |
7 |
26,513,619 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Cyp2g1
|
UTSW |
7 |
26,513,720 (GRCm39) |
splice site |
probably benign |
|
|
R0697:Cyp2g1
|
UTSW |
7 |
26,514,152 (GRCm39) |
nonsense |
probably null |
|
|
R0830:Cyp2g1
|
UTSW |
7 |
26,514,216 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1660:Cyp2g1
|
UTSW |
7 |
26,509,107 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2093:Cyp2g1
|
UTSW |
7 |
26,518,858 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2131:Cyp2g1
|
UTSW |
7 |
26,520,135 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4606:Cyp2g1
|
UTSW |
7 |
26,513,579 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5030:Cyp2g1
|
UTSW |
7 |
26,520,226 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5574:Cyp2g1
|
UTSW |
7 |
26,520,165 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5877:Cyp2g1
|
UTSW |
7 |
26,516,065 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6745:Cyp2g1
|
UTSW |
7 |
26,513,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7040:Cyp2g1
|
UTSW |
7 |
26,520,184 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7223:Cyp2g1
|
UTSW |
7 |
26,514,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7934:Cyp2g1
|
UTSW |
7 |
26,518,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8112:Cyp2g1
|
UTSW |
7 |
26,518,886 (GRCm39) |
missense |
probably benign |
|
|
R8177:Cyp2g1
|
UTSW |
7 |
26,518,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8194:Cyp2g1
|
UTSW |
7 |
26,514,159 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9043:Cyp2g1
|
UTSW |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9406:Cyp2g1
|
UTSW |
7 |
26,518,910 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9441:Cyp2g1
|
UTSW |
7 |
26,514,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
X0067:Cyp2g1
|
UTSW |
7 |
26,520,187 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
| Posted On |
2016-08-02 |
Incidental Mutation