Incidental Mutation 'IGL03168:Or5ac16'
ID 411708
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5ac16
Ensembl Gene ENSMUSG00000052537
Gene Name olfactory receptor family 5 subfamily AC member 16
Synonyms MOR182-8, GA_x54KRFPKG5P-55416332-55415412, Olfr198
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL03168
Quality Score
Status
Chromosome 16
Chromosomal Location 59021867-59022787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59022610 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 60 (Y60H)
Ref Sequence ENSEMBL: ENSMUSP00000146813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064452] [ENSMUST00000208244]
AlphaFold Q7TS40
Predicted Effect probably damaging
Transcript: ENSMUST00000064452
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000065535
Gene: ENSMUSG00000052537
AA Change: Y60H

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 4.9e-45 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208244
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c6 T C 13: 4,486,280 (GRCm39) V29A probably benign Het
Ankk1 C A 9: 49,327,068 (GRCm39) A704S possibly damaging Het
Aph1c G A 9: 66,740,619 (GRCm39) probably benign Het
Arglu1 T A 8: 8,733,960 (GRCm39) I119L probably benign Het
Brwd1 A T 16: 95,818,877 (GRCm39) S1318R possibly damaging Het
Calhm4 C T 10: 33,917,552 (GRCm39) V300I probably benign Het
Chd3 A G 11: 69,239,741 (GRCm39) probably benign Het
Colq T C 14: 31,246,377 (GRCm39) Y445C probably damaging Het
Cyp2a4 A T 7: 26,012,975 (GRCm39) probably benign Het
Cyp2j7 C T 4: 96,118,274 (GRCm39) M106I probably benign Het
Erfe T G 1: 91,299,164 (GRCm39) N302K probably damaging Het
Fggy A T 4: 95,815,046 (GRCm39) probably benign Het
Gata3 A G 2: 9,873,625 (GRCm39) Y290H probably damaging Het
Grik4 T C 9: 42,582,539 (GRCm39) T136A probably damaging Het
Hc G T 2: 34,914,210 (GRCm39) N832K probably benign Het
Jhy A T 9: 40,828,848 (GRCm39) S353T possibly damaging Het
Krt40 T A 11: 99,433,854 (GRCm39) Q44L possibly damaging Het
Ksr2 T C 5: 117,886,846 (GRCm39) F794S probably damaging Het
Or2l13 A T 16: 19,305,969 (GRCm39) H127L probably benign Het
Or2n1e A C 17: 38,585,682 (GRCm39) S7R probably damaging Het
Or4p7 A G 2: 88,221,938 (GRCm39) M116V probably damaging Het
Or5t9 A G 2: 86,659,607 (GRCm39) I170M possibly damaging Het
Or8b1c A G 9: 38,384,315 (GRCm39) T91A probably benign Het
Pcdhb17 A G 18: 37,618,825 (GRCm39) E205G probably benign Het
Pon3 A T 6: 5,256,177 (GRCm39) I17K possibly damaging Het
Prkd2 A G 7: 16,584,188 (GRCm39) D347G possibly damaging Het
Prkdc A G 16: 15,652,030 (GRCm39) I3806V probably benign Het
Qpct C A 17: 79,359,753 (GRCm39) A20E unknown Het
Rap1a A G 3: 105,657,587 (GRCm39) S11P probably damaging Het
Rnf145 C A 11: 44,445,985 (GRCm39) T273K probably damaging Het
Speg T C 1: 75,364,831 (GRCm39) I298T probably damaging Het
Syt6 G A 3: 103,494,943 (GRCm39) V303M probably damaging Het
Tpr A G 1: 150,284,508 (GRCm39) I324M probably benign Het
Uggt2 A G 14: 119,315,080 (GRCm39) F330L probably damaging Het
Unc45a A T 7: 79,982,881 (GRCm39) L348Q probably damaging Het
Vmn1r17 T A 6: 57,337,583 (GRCm39) I212F probably benign Het
Vmn2r68 A C 7: 84,870,972 (GRCm39) N770K probably damaging Het
Zfhx3 T C 8: 109,673,132 (GRCm39) V1394A probably damaging Het
Other mutations in Or5ac16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Or5ac16 APN 16 59,022,460 (GRCm39) missense possibly damaging 0.94
IGL03053:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
R1355:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1370:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1510:Or5ac16 UTSW 16 59,022,546 (GRCm39) missense probably damaging 0.99
R1777:Or5ac16 UTSW 16 59,022,379 (GRCm39) missense probably benign 0.35
R1962:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R1964:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R5409:Or5ac16 UTSW 16 59,021,920 (GRCm39) missense probably damaging 1.00
R5642:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R5704:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R6323:Or5ac16 UTSW 16 59,022,645 (GRCm39) missense probably damaging 1.00
R6829:Or5ac16 UTSW 16 59,021,898 (GRCm39) missense probably damaging 1.00
R7315:Or5ac16 UTSW 16 59,022,496 (GRCm39) missense probably benign 0.00
R7738:Or5ac16 UTSW 16 59,022,318 (GRCm39) missense probably benign 0.00
R8540:Or5ac16 UTSW 16 59,022,323 (GRCm39) missense possibly damaging 0.56
R8815:Or5ac16 UTSW 16 59,022,264 (GRCm39) missense possibly damaging 0.78
R8844:Or5ac16 UTSW 16 59,021,929 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02