Incidental Mutation 'IGL03171:Gm4778'
ID411825
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm4778
Ensembl Gene ENSMUSG00000089696
Gene Namepredicted gene 4778
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.920) question?
Stock #IGL03171
Quality Score
Status
Chromosome3
Chromosomal Location94264036-94266784 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 94266455 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Asparagine at position 257 (H257N)
Ref Sequence ENSEMBL: ENSMUSP00000096477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098878] [ENSMUST00000159517]
Predicted Effect probably benign
Transcript: ENSMUST00000098878
AA Change: H257N

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000096477
Gene: ENSMUSG00000089696
AA Change: H257N

DomainStartEndE-ValueType
MATH 25 134 6.01e-8 SMART
BTB 192 291 7.66e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159517
AA Change: H253N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000123868
Gene: ENSMUSG00000089696
AA Change: H253N

DomainStartEndE-ValueType
MATH 21 130 6.01e-8 SMART
BTB 188 287 7.66e-26 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003E16Rik T A 6: 83,162,395 F434Y possibly damaging Het
Adam19 G T 11: 46,138,854 A709S probably damaging Het
Adgrf3 A T 5: 30,196,294 L42Q probably damaging Het
D430041D05Rik T C 2: 104,241,163 N1264S possibly damaging Het
Dnah9 T G 11: 65,981,241 K2721T probably benign Het
Efr3b C T 12: 3,968,622 A575T probably benign Het
Esco1 T C 18: 10,594,263 E341G probably damaging Het
Ezh2 G A 6: 47,540,781 R574* probably null Het
Fam169a G T 13: 97,110,014 probably benign Het
Fry T C 5: 150,380,809 Y555H probably damaging Het
Gm17175 A C 14: 51,571,608 S100R probably damaging Het
Gm527 T C 12: 64,921,157 Y118H probably damaging Het
Gm8765 T A 13: 50,702,352 S675R probably benign Het
H2-M10.4 G T 17: 36,461,250 T202N probably damaging Het
Igf1 A T 10: 87,864,821 T36S probably damaging Het
Ints8 C T 4: 11,231,702 V428I probably benign Het
Itga6 G A 2: 71,841,329 probably null Het
Jmjd1c A G 10: 67,225,498 E1210G possibly damaging Het
Kdm2a A T 19: 4,356,764 V134E probably damaging Het
Limch1 C A 5: 67,034,194 N947K possibly damaging Het
Met T C 6: 17,562,273 probably benign Het
Neb A G 2: 52,216,364 probably benign Het
Ogg1 A G 6: 113,333,414 I274V possibly damaging Het
Ola1 A T 2: 73,156,853 I145K probably benign Het
Olfr458 G A 6: 42,460,530 T163I possibly damaging Het
Pacrg A G 17: 10,576,533 V166A possibly damaging Het
Pira2 T A 7: 3,842,605 E260V probably damaging Het
Prickle3 T C X: 7,665,287 C277R probably damaging Het
Psen1 A G 12: 83,714,864 T147A probably damaging Het
Pxk C T 14: 8,151,014 probably benign Het
Scn11a G A 9: 119,819,847 P50L probably benign Het
Scn4a C A 11: 106,345,592 V281L probably benign Het
Shcbp1 A G 8: 4,739,166 I551T probably benign Het
Snx13 T A 12: 35,100,540 I281N probably benign Het
Tdo2 T C 3: 81,967,029 K209E probably benign Het
Trip6 C T 5: 137,312,884 R190Q probably benign Het
Ttc30a1 C T 2: 75,980,507 A411T probably benign Het
Ubqln1 T A 13: 58,180,858 E426D probably damaging Het
Zfp607b C A 7: 27,693,595 N49K possibly damaging Het
Other mutations in Gm4778
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01767:Gm4778 APN 3 94266484 missense probably benign 0.00
IGL02032:Gm4778 APN 3 94266333 missense probably damaging 1.00
IGL02694:Gm4778 APN 3 94266152 missense probably benign
R0195:Gm4778 UTSW 3 94265922 missense possibly damaging 0.79
R0739:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1064:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1149:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1149:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1150:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1152:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1284:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1286:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1287:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1349:Gm4778 UTSW 3 94266128 missense possibly damaging 0.94
R1358:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1372:Gm4778 UTSW 3 94266128 missense possibly damaging 0.94
R1383:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1399:Gm4778 UTSW 3 94265795 missense probably benign 0.17
R1756:Gm4778 UTSW 3 94266218 missense probably benign
R1996:Gm4778 UTSW 3 94265711 missense probably benign 0.00
R2679:Gm4778 UTSW 3 94265910 missense probably damaging 1.00
R2878:Gm4778 UTSW 3 94266480 missense possibly damaging 0.69
R5108:Gm4778 UTSW 3 94265835 missense probably damaging 1.00
R5706:Gm4778 UTSW 3 94266652 missense possibly damaging 0.91
R6251:Gm4778 UTSW 3 94265901 missense probably damaging 1.00
R6928:Gm4778 UTSW 3 94266548 missense probably benign 0.31
R7091:Gm4778 UTSW 3 94266638 missense probably damaging 1.00
R7264:Gm4778 UTSW 3 94265738 missense possibly damaging 0.86
R7503:Gm4778 UTSW 3 94266473 missense probably benign 0.29
Posted On2016-08-02