Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03172:Zdhhc21'

411902

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zdhhc21

Ensembl Gene

ENSMUSG00000028403

Gene Name

zinc finger, DHHC domain containing 21

Synonyms

9130404H11Rik, D130004H04Rik, dep

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.126) question?

Stock #

IGL03172

Quality Score

Status

Chromosome

Chromosomal Location

82716975-82778195 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

G to A at 82724564 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000133630 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030110] [ENSMUST00000107239] [ENSMUST00000173741]

AlphaFold

Q9D270

Predicted Effect

probably benign
Transcript: ENSMUST00000030110

SMART Domains

Protein: ENSMUSP00000030110
Gene: ENSMUSG00000028403

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
low complexity region	43	58	N/A	INTRINSIC
Pfam:zf-DHHC	61	217	5.6e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000107239

SMART Domains

Protein: ENSMUSP00000102859
Gene: ENSMUSG00000028403

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
transmembrane domain	45	65	N/A	INTRINSIC
Pfam:zf-DHHC	85	218	3.6e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000173741

SMART Domains

Protein: ENSMUSP00000133630
Gene: ENSMUSG00000028403

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
low complexity region	43	58	N/A	INTRINSIC
Pfam:zf-DHHC	61	125	1.5e-16	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutants of this epidermal acting gene have thin, short hair, many misshapen and disoriented hair follicles, and clumps of pigment reflecting remains of degenerating follicles. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930111J21Rik1	T	C	11: 48,839,003 (GRCm39)	H528R	probably damaging	Het
A530053G22Rik	A	T	6: 60,379,047 (GRCm39)		noncoding transcript	Het
Aagab	A	G	9: 63,542,676 (GRCm39)		probably benign	Het
Aknad1	A	T	3: 108,688,519 (GRCm39)	I616F	possibly damaging	Het
Ap2a1	A	C	7: 44,553,479 (GRCm39)	D629E	probably benign	Het
Apc2	C	A	10: 80,149,220 (GRCm39)	Q1425K	probably damaging	Het
Asf1b	A	C	8: 84,694,542 (GRCm39)	H102P	probably benign	Het
Celf6	C	T	9: 59,489,565 (GRCm39)	A90V	probably damaging	Het
Chrna2	A	T	14: 66,379,688 (GRCm39)	Q9L	probably benign	Het
Csnk1g3	A	G	18: 54,086,356 (GRCm39)	I420M	possibly damaging	Het
Eml3	T	C	19: 8,916,543 (GRCm39)		probably benign	Het
Epn3	T	C	11: 94,382,456 (GRCm39)	N508S	possibly damaging	Het
Fam120a	T	C	13: 49,063,812 (GRCm39)	Y608C	probably damaging	Het
Fbn1	A	C	2: 125,162,888 (GRCm39)	C2133G	possibly damaging	Het
Fhl5	A	G	4: 25,211,309 (GRCm39)	F128L	probably damaging	Het
Fn1	T	C	1: 71,680,421 (GRCm39)	N428S	probably damaging	Het
Fxr2	T	C	11: 69,540,665 (GRCm39)		probably null	Het
Gabrp	T	C	11: 33,504,388 (GRCm39)	Y309C	probably damaging	Het
Golga2	A	G	2: 32,182,168 (GRCm39)	I50V	probably benign	Het
Ifi203	C	T	1: 173,764,158 (GRCm39)	G105R	possibly damaging	Het
Itgav	A	T	2: 83,596,190 (GRCm39)	Q201L	possibly damaging	Het
Jade2	T	C	11: 51,716,198 (GRCm39)	T336A	probably damaging	Het
Kdm4b	A	G	17: 56,708,649 (GRCm39)	D996G	probably damaging	Het
Me2	A	G	18: 73,903,797 (GRCm39)	I557T	probably benign	Het
Memo1	A	C	17: 74,551,996 (GRCm39)	L100R	probably damaging	Het
Mrps2	A	G	2: 28,359,818 (GRCm39)	N225S	probably damaging	Het
Ndufa2	A	G	18: 36,877,278 (GRCm39)		probably null	Het
Or2g7	G	T	17: 38,378,275 (GRCm39)	C71F	probably damaging	Het
Or7g19	G	A	9: 18,856,757 (GRCm39)	S271N	probably benign	Het
Pak5	G	T	2: 135,940,310 (GRCm39)	Y501*	probably null	Het
Pot1b	A	T	17: 56,002,206 (GRCm39)	F123I	possibly damaging	Het
Rev3l	T	C	10: 39,700,786 (GRCm39)	V1761A	probably benign	Het
Samd3	T	A	10: 26,106,064 (GRCm39)	V14E	probably damaging	Het
Slc4a8	G	A	15: 100,697,598 (GRCm39)	A605T	probably benign	Het
Smgc	A	T	15: 91,744,642 (GRCm39)	D333V	probably damaging	Het
Spata4	A	G	8: 55,055,440 (GRCm39)	I147V	probably benign	Het
Ttc23l	G	A	15: 10,537,652 (GRCm39)	S206L	probably benign	Het
Vmn2r73	G	A	7: 85,507,495 (GRCm39)	H606Y	probably benign	Het
Vsig8	A	G	1: 172,387,916 (GRCm39)	N2S	probably damaging	Het
Wdr17	A	C	8: 55,114,515 (GRCm39)	I667R	probably damaging	Het
Yif1b	A	G	7: 28,937,873 (GRCm39)		probably null	Het
Zbtb5	A	T	4: 44,994,003 (GRCm39)	H460Q	possibly damaging	Het
Zfp944	A	T	17: 22,559,018 (GRCm39)	H76Q	probably damaging	Het
Zkscan1	A	G	5: 138,092,264 (GRCm39)	Q146R	probably benign	Het

Other mutations in Zdhhc21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02887:Zdhhc21	APN	4	82,762,427 (GRCm39)	missense	probably benign	0.43
cornu	UTSW	4	82,725,292 (GRCm39)	missense	probably damaging	1.00
hadrosaur	UTSW	4	82,738,568 (GRCm39)	missense	possibly damaging	0.68
R4393:Zdhhc21	UTSW	4	82,765,891 (GRCm39)	missense	possibly damaging	0.90
R4701:Zdhhc21	UTSW	4	82,738,571 (GRCm39)	missense	possibly damaging	0.92
R4910:Zdhhc21	UTSW	4	82,738,568 (GRCm39)	missense	possibly damaging	0.68
R5288:Zdhhc21	UTSW	4	82,765,929 (GRCm39)	missense	probably damaging	1.00
R5339:Zdhhc21	UTSW	4	82,756,550 (GRCm39)	missense	probably damaging	1.00
R6363:Zdhhc21	UTSW	4	82,765,911 (GRCm39)	missense	probably damaging	1.00
R8435:Zdhhc21	UTSW	4	82,753,714 (GRCm39)	missense	probably damaging	0.99
R8723:Zdhhc21	UTSW	4	82,762,439 (GRCm39)	missense	probably benign	0.00
R9089:Zdhhc21	UTSW	4	82,725,292 (GRCm39)	missense	probably damaging	1.00
R9400:Zdhhc21	UTSW	4	82,753,687 (GRCm39)	missense	probably benign	0.28

Posted On

2016-08-02