Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03173:Tti1'

411930

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tti1

Ensembl Gene

ENSMUSG00000027650

Gene Name

TELO2 interacting protein 1

Synonyms

2610036D13Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.957) question?

Stock #

IGL03173

Quality Score

Status

Chromosome

Chromosomal Location

157823723-157870353 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 157848932 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000116592 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029179] [ENSMUST00000109522] [ENSMUST00000124338]

AlphaFold

Q91V83

Predicted Effect

probably benign
Transcript: ENSMUST00000029179

SMART Domains

Protein: ENSMUSP00000029179
Gene: ENSMUSG00000027650

Domain	Start	End	E-Value	Type
low complexity region	89	101	N/A	INTRINSIC
low complexity region	175	189	N/A	INTRINSIC
low complexity region	194	206	N/A	INTRINSIC
low complexity region	306	319	N/A	INTRINSIC
low complexity region	401	411	N/A	INTRINSIC
low complexity region	494	504	N/A	INTRINSIC
low complexity region	752	768	N/A	INTRINSIC
SCOP:d1gw5a_	855	1044	3e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109522

SMART Domains

Protein: ENSMUSP00000105148
Gene: ENSMUSG00000027650

Domain	Start	End	E-Value	Type
low complexity region	89	101	N/A	INTRINSIC
low complexity region	175	189	N/A	INTRINSIC
low complexity region	194	206	N/A	INTRINSIC
low complexity region	306	319	N/A	INTRINSIC
low complexity region	401	411	N/A	INTRINSIC
low complexity region	494	504	N/A	INTRINSIC
low complexity region	752	768	N/A	INTRINSIC
SCOP:d1gw5a_	855	1044	3e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000124338

SMART Domains

Protein: ENSMUSP00000116592
Gene: ENSMUSG00000027650

Domain	Start	End	E-Value	Type
low complexity region	89	101	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126541

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atg2b	T	C	12: 105,624,553 (GRCm39)	K649E	possibly damaging	Het
Cnnm4	A	G	1: 36,512,173 (GRCm39)		probably benign	Het
Cntrob	C	T	11: 69,200,853 (GRCm39)	A503T	possibly damaging	Het
D3Ertd751e	T	A	3: 41,710,497 (GRCm39)	Y170N	probably damaging	Het
Ddx23	T	C	15: 98,548,885 (GRCm39)	I306V	probably benign	Het
Ep400	A	G	5: 110,856,737 (GRCm39)		probably benign	Het
Gmps	T	C	3: 63,897,750 (GRCm39)	V234A	probably damaging	Het
Hivep2	G	T	10: 14,003,726 (GRCm39)	G108V	possibly damaging	Het
Irgc	T	C	7: 24,132,727 (GRCm39)	E30G	probably damaging	Het
Krt75	T	C	15: 101,481,162 (GRCm39)	Y204C	probably damaging	Het
Ms4a14	G	A	19: 11,281,560 (GRCm39)	L333F	possibly damaging	Het
Or51l4	A	G	7: 103,404,183 (GRCm39)	V203A	probably benign	Het
Or5an6	T	A	19: 12,372,410 (GRCm39)	M261K	possibly damaging	Het
Or8k27	A	T	2: 86,275,788 (GRCm39)	C179*	probably null	Het
Pitpnm3	G	A	11: 71,983,389 (GRCm39)	T80I	probably benign	Het
Pou2f2	T	C	7: 24,799,371 (GRCm39)		probably benign	Het
Slc34a1	T	C	13: 55,561,089 (GRCm39)	L518P	probably damaging	Het
Sorbs1	T	A	19: 40,351,706 (GRCm39)	T235S	probably damaging	Het
Ssxa1	C	T	X: 20,985,224 (GRCm39)	R41C	probably benign	Het
Syt2	A	G	1: 134,671,317 (GRCm39)	N142D	possibly damaging	Het
Taf3	A	G	2: 9,957,738 (GRCm39)	V143A	probably damaging	Het
Trav13-5	T	C	14: 54,033,534 (GRCm39)		probably benign	Het
Vmn2r13	T	C	5: 109,319,645 (GRCm39)	E445G	possibly damaging	Het
Zfp663	G	T	2: 165,194,419 (GRCm39)	T600K	probably damaging	Het
Zfp750	G	A	11: 121,404,651 (GRCm39)	Q75*	probably null	Het

Other mutations in Tti1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00434:Tti1	APN	2	157,850,885 (GRCm39)	missense	probably damaging	1.00
IGL00434:Tti1	APN	2	157,850,886 (GRCm39)	missense	probably damaging	1.00
IGL00820:Tti1	APN	2	157,850,888 (GRCm39)	missense	probably damaging	1.00
IGL00949:Tti1	APN	2	157,824,319 (GRCm39)	missense	probably benign	0.00
IGL01080:Tti1	APN	2	157,824,379 (GRCm39)	missense	probably damaging	1.00
IGL01084:Tti1	APN	2	157,824,379 (GRCm39)	missense	probably damaging	1.00
IGL01339:Tti1	APN	2	157,851,050 (GRCm39)	missense	possibly damaging	0.80
IGL01685:Tti1	APN	2	157,842,705 (GRCm39)	missense	probably benign	0.01
IGL01866:Tti1	APN	2	157,849,618 (GRCm39)	missense	probably benign	0.27
IGL01903:Tti1	APN	2	157,842,542 (GRCm39)	missense	probably benign	0.01
IGL03142:Tti1	APN	2	157,842,597 (GRCm39)	missense	probably damaging	0.99
IGL03385:Tti1	APN	2	157,834,945 (GRCm39)	missense	possibly damaging	0.86
R0413:Tti1	UTSW	2	157,837,396 (GRCm39)	missense	probably benign	0.00
R0601:Tti1	UTSW	2	157,835,292 (GRCm39)	missense	probably damaging	0.99
R1718:Tti1	UTSW	2	157,850,144 (GRCm39)	missense	probably benign	0.40
R1760:Tti1	UTSW	2	157,834,955 (GRCm39)	missense	possibly damaging	0.87
R1761:Tti1	UTSW	2	157,849,617 (GRCm39)	missense	probably benign	0.01
R1968:Tti1	UTSW	2	157,850,966 (GRCm39)	missense	possibly damaging	0.66
R2054:Tti1	UTSW	2	157,849,365 (GRCm39)	missense	possibly damaging	0.79
R2131:Tti1	UTSW	2	157,842,663 (GRCm39)	missense	probably benign
R3886:Tti1	UTSW	2	157,850,870 (GRCm39)	missense	possibly damaging	0.74
R4479:Tti1	UTSW	2	157,850,315 (GRCm39)	missense	possibly damaging	0.95
R4647:Tti1	UTSW	2	157,848,940 (GRCm39)	unclassified	probably benign
R5124:Tti1	UTSW	2	157,850,115 (GRCm39)	missense	probably damaging	0.99
R5145:Tti1	UTSW	2	157,850,432 (GRCm39)	missense	probably benign	0.30
R5852:Tti1	UTSW	2	157,842,593 (GRCm39)	missense	probably damaging	1.00
R6667:Tti1	UTSW	2	157,850,347 (GRCm39)	nonsense	probably null
R6714:Tti1	UTSW	2	157,848,971 (GRCm39)	missense	possibly damaging	0.73
R6719:Tti1	UTSW	2	157,824,220 (GRCm39)	missense	probably benign	0.01
R7143:Tti1	UTSW	2	157,849,596 (GRCm39)	missense	probably benign
R7490:Tti1	UTSW	2	157,837,392 (GRCm39)	missense	probably damaging	1.00
R7540:Tti1	UTSW	2	157,849,916 (GRCm39)	missense	probably benign	0.43
R7549:Tti1	UTSW	2	157,849,088 (GRCm39)	missense	probably damaging	1.00
R7641:Tti1	UTSW	2	157,850,949 (GRCm39)	missense	possibly damaging	0.92
R7654:Tti1	UTSW	2	157,850,474 (GRCm39)	missense	probably benign	0.00
R7716:Tti1	UTSW	2	157,842,618 (GRCm39)	missense	probably benign	0.43
R7722:Tti1	UTSW	2	157,849,527 (GRCm39)	missense	probably benign	0.00
R7898:Tti1	UTSW	2	157,835,390 (GRCm39)	missense	probably benign	0.00
R8117:Tti1	UTSW	2	157,849,418 (GRCm39)	missense	probably damaging	1.00
R8145:Tti1	UTSW	2	157,849,509 (GRCm39)	nonsense	probably null
R8249:Tti1	UTSW	2	157,842,635 (GRCm39)	missense	probably benign
R8712:Tti1	UTSW	2	157,834,930 (GRCm39)	missense	probably damaging	1.00
R8784:Tti1	UTSW	2	157,850,514 (GRCm39)	missense	probably benign	0.02
R8912:Tti1	UTSW	2	157,851,188 (GRCm39)	missense	probably benign	0.00
R9352:Tti1	UTSW	2	157,842,692 (GRCm39)	missense	probably benign	0.00
R9725:Tti1	UTSW	2	157,849,304 (GRCm39)	missense	probably benign	0.13
Z1176:Tti1	UTSW	2	157,824,349 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02