Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03176:Rnf186'

411994

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rnf186

Ensembl Gene

ENSMUSG00000070661

Gene Name

ring finger protein 186

Synonyms

9130020G10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL03176

Quality Score

Status

Chromosome

Chromosomal Location

138694430-138695676 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 138695231 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 257 (N257S)

Ref Sequence

ENSEMBL: ENSMUSP00000111780 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043042] [ENSMUST00000050949] [ENSMUST00000116094] [ENSMUST00000123636]

AlphaFold

Q9D241

Predicted Effect

probably benign
Transcript: ENSMUST00000043042

SMART Domains

Protein: ENSMUSP00000041388
Gene: ENSMUSG00000041143

Domain	Start	End	E-Value	Type
Pfam:DUF726	182	518	1.1e-138	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000050949

SMART Domains

Protein: ENSMUSP00000059320
Gene: ENSMUSG00000041143

Domain	Start	End	E-Value	Type
Pfam:DUF726	182	518	5.3e-145	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000116094
AA Change: N257S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000111780
Gene: ENSMUSG00000070661
AA Change: N257S

Domain	Start	End	E-Value	Type
RING	93	138	4.99e-5	SMART
transmembrane domain	208	226	N/A	INTRINSIC
transmembrane domain	230	252	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000123636

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124835

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam23	C	A	1: 63,602,575 (GRCm39)	P579Q	probably damaging	Het
Adam6a	A	G	12: 113,509,822 (GRCm39)	T732A	probably benign	Het
Ahnak	T	A	19: 8,985,530 (GRCm39)	N2271K	possibly damaging	Het
Ahnak	T	C	19: 8,979,813 (GRCm39)	S366P	probably damaging	Het
Akr1a1	A	G	4: 116,496,272 (GRCm39)	L213S	probably damaging	Het
Ammecr1l	T	A	18: 31,905,102 (GRCm39)	D114E	possibly damaging	Het
Casq2	G	T	3: 102,033,970 (GRCm39)	V167L	possibly damaging	Het
Cd164l2	T	C	4: 132,951,565 (GRCm39)	I172T	possibly damaging	Het
Clec4g	C	T	8: 3,768,441 (GRCm39)	V97M	possibly damaging	Het
Dnah8	T	A	17: 30,913,011 (GRCm39)	N1068K	probably benign	Het
Epyc	A	G	10: 97,485,562 (GRCm39)	M1V	probably null	Het
Eya3	A	G	4: 132,439,233 (GRCm39)	E437G	possibly damaging	Het
Fbln1	C	T	15: 85,128,507 (GRCm39)	T568I	possibly damaging	Het
Fcrl1	A	T	3: 87,298,564 (GRCm39)	N353I	probably damaging	Het
Gm10272	A	T	10: 77,542,467 (GRCm39)	H3L	probably null	Het
Gm15130	A	G	2: 110,978,846 (GRCm39)	S32P	unknown	Het
Gm20379	C	A	13: 92,442,529 (GRCm39)		probably benign	Het
Igf2r	A	T	17: 12,935,559 (GRCm39)	Y644N	probably damaging	Het
Krtap4-9	T	C	11: 99,676,106 (GRCm39)		probably benign	Het
Man2c1	A	G	9: 57,048,030 (GRCm39)	N739D	probably benign	Het
Mcm5	C	T	8: 75,836,481 (GRCm39)	T49M	possibly damaging	Het
Otof	C	T	5: 30,562,520 (GRCm39)		probably null	Het
Ptgr2	C	T	12: 84,354,668 (GRCm39)	T283I	probably damaging	Het
Rhox4c	G	T	X: 36,662,181 (GRCm39)	G15V	probably benign	Het
Rnd1	A	T	15: 98,568,569 (GRCm39)	L203H	probably damaging	Het
Rsf1	T	C	7: 97,328,357 (GRCm39)		probably benign	Het
Ryr2	G	A	13: 11,756,909 (GRCm39)	Q1582*	probably null	Het
Sntg2	G	A	12: 30,317,022 (GRCm39)		probably benign	Het
Spata31d1c	A	G	13: 65,184,825 (GRCm39)	D789G	probably benign	Het
Strc	A	C	2: 121,202,661 (GRCm39)	L1168R	probably damaging	Het
Tmtc3	A	T	10: 100,301,993 (GRCm39)	S319T	possibly damaging	Het
Vmn1r88	A	T	7: 12,911,779 (GRCm39)	D45V	probably damaging	Het
Vps13d	A	T	4: 144,801,533 (GRCm39)	F3531I	probably benign	Het

Other mutations in Rnf186

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1856:Rnf186	UTSW	4	138,694,673 (GRCm39)	missense	probably benign	0.32
R4811:Rnf186	UTSW	4	138,694,498 (GRCm39)	missense	probably benign	0.08
R4871:Rnf186	UTSW	4	138,695,254 (GRCm39)	missense	probably benign	0.42
R5008:Rnf186	UTSW	4	138,694,540 (GRCm39)	missense	probably benign	0.00
R5619:Rnf186	UTSW	4	138,694,715 (GRCm39)	missense	probably benign	0.43
R6051:Rnf186	UTSW	4	138,695,277 (GRCm39)	missense	probably damaging	1.00
R6158:Rnf186	UTSW	4	138,694,565 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02