Incidental Mutation 'IGL03183:Vmn2r121'
ID412314
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r121
Ensembl Gene ENSMUSG00000072049
Gene Namevomeronasal 2, receptor 121
SynonymsEG625699
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL03183
Quality Score
Status
ChromosomeX
Chromosomal Location124127339-124135910 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 124132326 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 378 (T378I)
Ref Sequence ENSEMBL: ENSMUSP00000092067 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094491]
Predicted Effect probably benign
Transcript: ENSMUST00000094491
AA Change: T378I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: T378I

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 448 3.2e-26 PFAM
Pfam:NCD3G 506 560 2.1e-19 PFAM
Pfam:7tm_3 593 828 3.8e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh6a1 A G 12: 84,436,440 probably null Het
Ano2 A T 6: 125,710,629 K32N probably benign Het
Asic1 A G 15: 99,672,017 H73R probably benign Het
B3glct A G 5: 149,754,142 D412G probably damaging Het
Baz2b T C 2: 59,903,296 I1891V probably benign Het
Cc2d2a A G 5: 43,732,379 E1278G probably damaging Het
Ccdc116 T C 16: 17,142,854 E33G probably benign Het
Celf4 T A 18: 25,537,739 Q129L probably benign Het
Celf4 G T 18: 25,537,740 Q129K probably benign Het
Col18a1 A G 10: 77,073,754 S817P probably damaging Het
Corin A G 5: 72,301,586 V940A probably damaging Het
Dlgap2 A T 8: 14,727,525 N257Y possibly damaging Het
Dnah2 C A 11: 69,458,488 V2441L possibly damaging Het
Evpl C T 11: 116,221,612 E1751K probably damaging Het
Fam35a T C 14: 34,245,186 T690A probably benign Het
Fat1 G A 8: 44,950,586 E125K probably damaging Het
Fras1 A T 5: 96,733,781 probably benign Het
Fryl G A 5: 73,076,695 P1496S probably benign Het
G3bp2 A C 5: 92,055,046 M362R possibly damaging Het
Grk5 T C 19: 61,069,336 F158S probably damaging Het
Hmbox1 G T 14: 64,887,599 Q188K probably damaging Het
Ift172 A T 5: 31,272,004 D604E probably benign Het
Igkv6-32 T A 6: 70,074,572 T5S probably benign Het
Impa1 A G 3: 10,322,994 Y123H probably damaging Het
Itgb4 C T 11: 115,988,724 T612M probably damaging Het
Med12l T A 3: 59,037,555 probably null Het
Meis2 A G 2: 116,059,521 L160S probably damaging Het
Micu1 C T 10: 59,728,048 R31* probably null Het
Nlrp9a G T 7: 26,557,457 A167S probably damaging Het
Olfr1408 A G 1: 173,130,858 Y120H probably damaging Het
Olfr1425 A T 19: 12,074,028 N201K probably damaging Het
Plpp6 A G 19: 28,964,671 N224S possibly damaging Het
Sdk2 T A 11: 113,850,984 H803L probably benign Het
Slc36a1 T A 11: 55,228,191 Y331N probably damaging Het
Spata31d1c A T 13: 65,035,195 I184F possibly damaging Het
Stat3 T C 11: 100,902,756 I338V possibly damaging Het
Stk10 T A 11: 32,604,143 V610E possibly damaging Het
Syna A G 5: 134,558,290 S602P probably benign Het
Tap2 T A 17: 34,205,425 probably benign Het
Tln1 T C 4: 43,539,084 probably benign Het
Tra2b C A 16: 22,254,553 probably benign Het
Ttc7b T C 12: 100,373,709 probably null Het
Wdr1 A T 5: 38,533,482 probably null Het
Wdr66 A G 5: 123,254,619 probably benign Het
Other mutations in Vmn2r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r121 APN X 124127802 missense probably benign 0.04
IGL00990:Vmn2r121 APN X 124127783 missense possibly damaging 0.95
IGL00990:Vmn2r121 APN X 124133716 missense probably benign 0.00
IGL01125:Vmn2r121 APN X 124132807 missense probably damaging 0.99
IGL01450:Vmn2r121 APN X 124131191 missense possibly damaging 0.57
IGL01619:Vmn2r121 APN X 124132300 missense probably benign
IGL01797:Vmn2r121 APN X 124131351 splice site probably benign
IGL02227:Vmn2r121 APN X 124132681 missense probably benign 0.44
IGL02971:Vmn2r121 APN X 124127894 missense probably damaging 1.00
IGL03058:Vmn2r121 APN X 124132921 missense probably benign 0.00
IGL03142:Vmn2r121 APN X 124132938 missense possibly damaging 0.94
E0370:Vmn2r121 UTSW X 124127920 missense probably benign 0.01
R0196:Vmn2r121 UTSW X 124132182 missense probably benign 0.03
R1381:Vmn2r121 UTSW X 124128140 missense probably damaging 1.00
R1399:Vmn2r121 UTSW X 124129848 missense possibly damaging 0.94
R1423:Vmn2r121 UTSW X 124129905 missense possibly damaging 0.52
R1687:Vmn2r121 UTSW X 124132791 missense probably benign 0.39
R2121:Vmn2r121 UTSW X 124133742 splice site probably null
R2124:Vmn2r121 UTSW X 124133742 splice site probably null
R3151:Vmn2r121 UTSW X 124131152 missense probably benign 0.20
R4460:Vmn2r121 UTSW X 124128584 missense probably benign 0.01
R4735:Vmn2r121 UTSW X 124128638 missense probably benign
R5332:Vmn2r121 UTSW X 124133575 missense probably benign
R6102:Vmn2r121 UTSW X 124133575 missense probably benign
X0023:Vmn2r121 UTSW X 124135657 missense possibly damaging 0.64
Posted On2016-08-02