Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03188:Vmn2r85'

412507

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r85

Ensembl Gene

ENSMUSG00000092048

Gene Name

vomeronasal 2, receptor 85

Synonyms

EG623734

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

IGL03188

Quality Score

Status

Chromosome

Chromosomal Location

130253658-130266615 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 130254612 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 691 (M691V)

Ref Sequence

ENSEMBL: ENSMUSP00000128792 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171811]

AlphaFold

G3UW56

Predicted Effect

probably benign
Transcript: ENSMUST00000171811
AA Change: M691V

PolyPhen 2 Score 0.156 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: M691V

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	77	425	9e-26	PFAM
Pfam:NCD3G	508	562	1.1e-18	PFAM
Pfam:7tm_3	595	831	3.7e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts18	C	A	8: 114,425,656 (GRCm39)	C1202F	probably damaging	Het
Ago2	C	T	15: 72,995,182 (GRCm39)	V466I	probably benign	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Aptx	A	T	4: 40,695,143 (GRCm39)		probably null	Het
Aurka	A	T	2: 172,205,688 (GRCm39)	D123E	possibly damaging	Het
Btaf1	T	C	19: 36,926,508 (GRCm39)	I60T	possibly damaging	Het
Ccdc154	A	T	17: 25,383,067 (GRCm39)		probably null	Het
Cct5	T	C	15: 31,598,148 (GRCm39)	N55S	probably benign	Het
Cntnap3	A	G	13: 64,929,559 (GRCm39)	S547P	probably damaging	Het
Efl1	T	A	7: 82,320,909 (GRCm39)	I114N	probably damaging	Het
Gprin1	T	C	13: 54,886,465 (GRCm39)	D603G	probably benign	Het
Il16	A	G	7: 83,337,371 (GRCm39)	S115P	probably benign	Het
Kalrn	C	A	16: 34,134,562 (GRCm39)	V401L	probably benign	Het
Kcnq4	T	A	4: 120,561,623 (GRCm39)	K482I	possibly damaging	Het
L3mbtl3	C	T	10: 26,218,515 (GRCm39)	A114T	unknown	Het
Lig1	G	A	7: 13,045,032 (GRCm39)		probably benign	Het
Lnx1	G	A	5: 74,780,924 (GRCm39)	T199M	probably damaging	Het
Mapk13	A	G	17: 28,995,557 (GRCm39)		probably benign	Het
Mfsd2b	A	T	12: 4,916,538 (GRCm39)		probably null	Het
Mrpl3	A	G	9: 104,934,264 (GRCm39)	D137G	probably benign	Het
Muc15	A	G	2: 110,562,044 (GRCm39)	D160G	probably benign	Het
Myh4	T	C	11: 67,137,369 (GRCm39)		probably null	Het
Nipa2	T	G	7: 55,582,680 (GRCm39)	N355T	probably benign	Het
Or11h4	A	T	14: 50,974,315 (GRCm39)	Y101*	probably null	Het
Or2v2	T	C	11: 49,004,536 (GRCm39)	N6D	probably damaging	Het
Or51a43	A	G	7: 103,717,945 (GRCm39)	S98P	possibly damaging	Het
Or5p60	T	C	7: 107,723,841 (GRCm39)	T210A	probably benign	Het
Pfkm	G	T	15: 98,021,124 (GRCm39)		probably null	Het
Ppip5k1	A	G	2: 121,157,327 (GRCm39)		probably benign	Het
Ppp1r18	A	G	17: 36,178,857 (GRCm39)	D244G	possibly damaging	Het
Rimoc1	A	G	15: 4,018,187 (GRCm39)	Y163H	probably damaging	Het
Scn2a	T	C	2: 65,501,997 (GRCm39)	S107P	probably damaging	Het
Scn5a	A	T	9: 119,351,632 (GRCm39)	I783N	probably damaging	Het
Snx1	A	G	9: 66,001,734 (GRCm39)	W307R	probably damaging	Het
Spata31g1	A	G	4: 42,971,225 (GRCm39)	Y186C	possibly damaging	Het
Stk11ip	G	A	1: 75,511,079 (GRCm39)	V928M	probably benign	Het
Tgm4	A	G	9: 122,874,101 (GRCm39)	M114V	probably null	Het
Trpm2	G	A	10: 77,754,743 (GRCm39)	R1248C	probably benign	Het
Txnrd1	T	C	10: 82,720,880 (GRCm39)	I347T	possibly damaging	Het
Unc5a	A	G	13: 55,147,316 (GRCm39)	S106G	probably damaging	Het
Zfp58	T	A	13: 67,639,528 (GRCm39)	Q321L	probably benign	Het

Other mutations in Vmn2r85

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01160:Vmn2r85	APN	10	130,254,690 (GRCm39)	missense	probably benign	0.22
IGL01298:Vmn2r85	APN	10	130,254,690 (GRCm39)	missense	probably benign	0.22
IGL01361:Vmn2r85	APN	10	130,254,690 (GRCm39)	missense	probably benign	0.22
IGL02185:Vmn2r85	APN	10	130,254,561 (GRCm39)	missense	probably benign	0.13
IGL02505:Vmn2r85	APN	10	130,261,449 (GRCm39)	missense	probably damaging	1.00
IGL02607:Vmn2r85	APN	10	130,262,290 (GRCm39)	missense	possibly damaging	0.89
IGL02755:Vmn2r85	APN	10	130,261,381 (GRCm39)	missense	probably damaging	0.98
IGL03366:Vmn2r85	APN	10	130,262,328 (GRCm39)	missense	probably benign	0.00
IGL03397:Vmn2r85	APN	10	130,261,263 (GRCm39)	missense	probably damaging	1.00
PIT4445001:Vmn2r85	UTSW	10	130,261,572 (GRCm39)	missense	probably benign	0.00
R0066:Vmn2r85	UTSW	10	130,261,770 (GRCm39)	missense	probably damaging	1.00
R0128:Vmn2r85	UTSW	10	130,255,054 (GRCm39)	splice site	probably benign
R0130:Vmn2r85	UTSW	10	130,255,054 (GRCm39)	splice site	probably benign
R0503:Vmn2r85	UTSW	10	130,258,609 (GRCm39)	missense	probably damaging	1.00
R0827:Vmn2r85	UTSW	10	130,265,387 (GRCm39)	missense	possibly damaging	0.89
R1432:Vmn2r85	UTSW	10	130,261,155 (GRCm39)	missense	possibly damaging	0.74
R1521:Vmn2r85	UTSW	10	130,261,788 (GRCm39)	missense	probably damaging	0.99
R2029:Vmn2r85	UTSW	10	130,261,443 (GRCm39)	nonsense	probably null
R2034:Vmn2r85	UTSW	10	130,262,242 (GRCm39)	splice site	probably benign
R2852:Vmn2r85	UTSW	10	130,255,035 (GRCm39)	missense	probably benign	0.03
R2853:Vmn2r85	UTSW	10	130,255,035 (GRCm39)	missense	probably benign	0.03
R3084:Vmn2r85	UTSW	10	130,261,081 (GRCm39)	missense	probably benign	0.00
R3085:Vmn2r85	UTSW	10	130,261,081 (GRCm39)	missense	probably benign	0.00
R3430:Vmn2r85	UTSW	10	130,254,758 (GRCm39)	missense	probably damaging	0.97
R3694:Vmn2r85	UTSW	10	130,254,171 (GRCm39)	missense	probably damaging	0.99
R3932:Vmn2r85	UTSW	10	130,254,336 (GRCm39)	missense	probably damaging	1.00
R4207:Vmn2r85	UTSW	10	130,254,574 (GRCm39)	missense	probably damaging	1.00
R4628:Vmn2r85	UTSW	10	130,261,235 (GRCm39)	missense	probably benign	0.00
R4814:Vmn2r85	UTSW	10	130,254,567 (GRCm39)	missense	probably benign	0.12
R4948:Vmn2r85	UTSW	10	130,254,990 (GRCm39)	missense	probably damaging	1.00
R4951:Vmn2r85	UTSW	10	130,261,113 (GRCm39)	missense	probably damaging	1.00
R4959:Vmn2r85	UTSW	10	130,257,302 (GRCm39)	missense	probably damaging	1.00
R5336:Vmn2r85	UTSW	10	130,258,574 (GRCm39)	missense	possibly damaging	0.63
R5643:Vmn2r85	UTSW	10	130,262,343 (GRCm39)	missense	probably damaging	1.00
R6061:Vmn2r85	UTSW	10	130,261,531 (GRCm39)	missense	probably benign	0.09
R6115:Vmn2r85	UTSW	10	130,258,672 (GRCm39)	missense	probably damaging	1.00
R6190:Vmn2r85	UTSW	10	130,261,330 (GRCm39)	missense	possibly damaging	0.88
R6518:Vmn2r85	UTSW	10	130,265,281 (GRCm39)	missense	probably benign	0.00
R6533:Vmn2r85	UTSW	10	130,262,529 (GRCm39)	missense	probably benign	0.00
R6610:Vmn2r85	UTSW	10	130,261,838 (GRCm39)	missense	probably damaging	0.97
R6809:Vmn2r85	UTSW	10	130,261,795 (GRCm39)	missense	probably benign
R6962:Vmn2r85	UTSW	10	130,261,452 (GRCm39)	missense	probably damaging	0.99
R7075:Vmn2r85	UTSW	10	130,258,557 (GRCm39)	missense	probably benign	0.06
R7104:Vmn2r85	UTSW	10	130,262,376 (GRCm39)	missense	probably benign
R7424:Vmn2r85	UTSW	10	130,254,849 (GRCm39)	missense	probably damaging	1.00
R7516:Vmn2r85	UTSW	10	130,254,852 (GRCm39)	missense	probably damaging	1.00
R7537:Vmn2r85	UTSW	10	130,258,735 (GRCm39)	missense	probably benign	0.01
R7768:Vmn2r85	UTSW	10	130,254,562 (GRCm39)	missense	probably damaging	1.00
R7810:Vmn2r85	UTSW	10	130,261,081 (GRCm39)	missense	probably benign	0.00
R8078:Vmn2r85	UTSW	10	130,265,364 (GRCm39)	nonsense	probably null
R8115:Vmn2r85	UTSW	10	130,261,820 (GRCm39)	missense	probably benign	0.06
R8262:Vmn2r85	UTSW	10	130,254,738 (GRCm39)	missense	probably damaging	0.98
R8395:Vmn2r85	UTSW	10	130,261,797 (GRCm39)	missense	probably damaging	0.99
R8409:Vmn2r85	UTSW	10	130,261,257 (GRCm39)	missense	probably benign	0.16
R8547:Vmn2r85	UTSW	10	130,261,311 (GRCm39)	missense	probably damaging	1.00
R8875:Vmn2r85	UTSW	10	130,254,171 (GRCm39)	missense	probably damaging	0.99
R9035:Vmn2r85	UTSW	10	130,261,479 (GRCm39)	missense	probably benign
R9040:Vmn2r85	UTSW	10	130,254,311 (GRCm39)	missense	probably damaging	1.00
R9115:Vmn2r85	UTSW	10	130,254,153 (GRCm39)	missense	probably benign	0.00
R9182:Vmn2r85	UTSW	10	130,265,350 (GRCm39)	missense	probably benign	0.00
R9245:Vmn2r85	UTSW	10	130,261,534 (GRCm39)	missense	probably damaging	1.00
R9245:Vmn2r85	UTSW	10	130,255,033 (GRCm39)	missense	possibly damaging	0.92
R9405:Vmn2r85	UTSW	10	130,261,215 (GRCm39)	missense	probably damaging	0.99
R9502:Vmn2r85	UTSW	10	130,261,387 (GRCm39)	missense	probably damaging	0.99
R9520:Vmn2r85	UTSW	10	130,254,993 (GRCm39)	missense	probably benign
R9653:Vmn2r85	UTSW	10	130,261,694 (GRCm39)	missense	probably damaging	0.99
Z1176:Vmn2r85	UTSW	10	130,261,713 (GRCm39)	missense	probably damaging	0.99
Z1177:Vmn2r85	UTSW	10	130,254,776 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02