Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03189:Tmem45a'

412555

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem45a

Ensembl Gene

ENSMUSG00000022754

Gene Name

transmembrane protein 45a

Synonyms

C630002M10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL03189

Quality Score

Status

Chromosome

Chromosomal Location

56625524-56706529 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 56631936 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 227 (Y227*)

Ref Sequence

ENSEMBL: ENSMUSP00000023435 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023435]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000023435
AA Change: Y227*

SMART Domains

Protein: ENSMUSP00000023435
Gene: ENSMUSG00000022754
AA Change: Y227*

Domain	Start	End	E-Value	Type
transmembrane domain	10	27	N/A	INTRINSIC
transmembrane domain	51	73	N/A	INTRINSIC
transmembrane domain	88	110	N/A	INTRINSIC
Pfam:DUF716	119	239	8.9e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148452

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	A	G	5: 8,895,814 (GRCm39)	T916A	probably benign	Het
Adam22	A	T	5: 8,161,897 (GRCm39)	Y50*	probably null	Het
Adprs	T	C	4: 126,211,087 (GRCm39)		probably benign	Het
Ahnak	G	A	19: 8,988,603 (GRCm39)	V3296M	possibly damaging	Het
Bfar	A	G	16: 13,505,365 (GRCm39)	D125G	possibly damaging	Het
Bmp3	A	T	5: 99,020,579 (GRCm39)	Q334L	probably benign	Het
Camsap2	A	T	1: 136,209,400 (GRCm39)	D697E	probably damaging	Het
Car11	A	G	7: 45,351,879 (GRCm39)	T103A	probably damaging	Het
Cecr2	T	A	6: 120,739,391 (GRCm39)	S1373T	probably benign	Het
Cenpm	A	G	15: 82,118,634 (GRCm39)	V160A	possibly damaging	Het
Chl1	A	T	6: 103,660,168 (GRCm39)	I365F	possibly damaging	Het
Col20a1	C	T	2: 180,651,200 (GRCm39)	Q1089*	probably null	Het
Csf1r	A	T	18: 61,239,058 (GRCm39)	T13S	probably benign	Het
Fam13a	T	C	6: 58,933,843 (GRCm39)	E249G	probably damaging	Het
Fgd6	G	A	10: 93,880,318 (GRCm39)	V391I	probably benign	Het
Fhdc1	G	A	3: 84,362,368 (GRCm39)		probably benign	Het
Fn3krp	T	C	11: 121,320,456 (GRCm39)	I267T	probably damaging	Het
Fras1	A	T	5: 96,890,930 (GRCm39)	I2820F	probably benign	Het
Fyb2	A	G	4: 104,872,939 (GRCm39)	I771V	probably damaging	Het
Gata3os	A	G	2: 9,888,634 (GRCm39)		probably benign	Het
Glis1	A	G	4: 107,472,248 (GRCm39)	Y275C	probably damaging	Het
Hdgf	A	G	3: 87,820,735 (GRCm39)	T62A	possibly damaging	Het
Hsd17b3	C	T	13: 64,210,901 (GRCm39)		probably null	Het
Ift56	C	T	6: 38,402,166 (GRCm39)	P553S	probably benign	Het
Iqgap1	T	A	7: 80,363,590 (GRCm39)	Y1655F	probably benign	Het
Izumo1	A	G	7: 45,274,588 (GRCm39)	D181G	probably damaging	Het
Lrp2	T	C	2: 69,268,822 (GRCm39)		probably benign	Het
Mark1	T	C	1: 184,651,890 (GRCm39)	N95S	probably damaging	Het
Mbd5	A	G	2: 49,147,763 (GRCm39)	K658E	probably damaging	Het
Mcm6	C	T	1: 128,272,039 (GRCm39)	D453N	probably damaging	Het
Mfsd14a	T	C	3: 116,435,504 (GRCm39)	D187G	probably benign	Het
Mrpl19	G	T	6: 81,938,974 (GRCm39)	S276*	probably null	Het
Ncoa2	G	A	1: 13,260,360 (GRCm39)	T105M	probably damaging	Het
Nop14	A	G	5: 34,807,972 (GRCm39)		probably benign	Het
Or2ah1	A	G	2: 85,653,902 (GRCm39)	T196A	probably benign	Het
Or2aj5	T	C	16: 19,425,341 (GRCm39)	T26A	probably benign	Het
Or5w19	G	A	2: 87,698,559 (GRCm39)	A75T	possibly damaging	Het
Otud7b	G	A	3: 96,062,795 (GRCm39)	S678N	probably benign	Het
Pcdhb6	G	A	18: 37,469,205 (GRCm39)	V25M	probably damaging	Het
Prpf39	G	T	12: 65,090,076 (GRCm39)	G5*	probably null	Het
Serpinb9d	T	C	13: 33,386,895 (GRCm39)	V321A	probably damaging	Het
Sh2b1	A	G	7: 126,067,702 (GRCm39)	S613P	possibly damaging	Het
Snx30	T	C	4: 59,857,452 (GRCm39)	I55T	probably benign	Het
Spata13	T	C	14: 60,929,063 (GRCm39)	I207T	possibly damaging	Het
Suco	T	C	1: 161,684,906 (GRCm39)		probably benign	Het
Svs5	A	G	2: 164,079,032 (GRCm39)	S292P	possibly damaging	Het
Tcam1	A	G	11: 106,176,212 (GRCm39)	I313V	probably benign	Het
Tnfsf15	A	G	4: 63,648,289 (GRCm39)		probably benign	Het
Vmn2r4	C	A	3: 64,296,589 (GRCm39)	R732L	possibly damaging	Het
Wdr7	C	T	18: 63,893,672 (GRCm39)	T602I	probably benign	Het

Other mutations in Tmem45a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01609:Tmem45a	APN	16	56,631,928 (GRCm39)	missense	probably benign	0.01
R1481:Tmem45a	UTSW	16	56,631,965 (GRCm39)	missense	possibly damaging	0.62
R1698:Tmem45a	UTSW	16	56,643,933 (GRCm39)	missense	probably benign	0.10
R1748:Tmem45a	UTSW	16	56,642,701 (GRCm39)	missense	possibly damaging	0.94
R1759:Tmem45a	UTSW	16	56,642,765 (GRCm39)	missense	probably benign
R1921:Tmem45a	UTSW	16	56,642,665 (GRCm39)	missense	probably benign	0.11
R2277:Tmem45a	UTSW	16	56,643,882 (GRCm39)	missense	probably damaging	1.00
R2279:Tmem45a	UTSW	16	56,643,882 (GRCm39)	missense	probably damaging	1.00
R3899:Tmem45a	UTSW	16	56,627,101 (GRCm39)	missense	probably damaging	1.00
R4941:Tmem45a	UTSW	16	56,642,652 (GRCm39)	missense	possibly damaging	0.62
R5489:Tmem45a	UTSW	16	56,646,074 (GRCm39)	splice site	probably null
R6914:Tmem45a	UTSW	16	56,646,145 (GRCm39)	missense	probably benign	0.00
R6942:Tmem45a	UTSW	16	56,646,145 (GRCm39)	missense	probably benign	0.00
R7064:Tmem45a	UTSW	16	56,642,767 (GRCm39)	missense	probably benign	0.00
R7197:Tmem45a	UTSW	16	56,632,026 (GRCm39)	missense	probably damaging	0.99
R7746:Tmem45a	UTSW	16	56,646,100 (GRCm39)	missense	probably damaging	0.98
R9301:Tmem45a	UTSW	16	56,627,134 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02