Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03189:Or5w19'

412559

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5w19

Ensembl Gene

ENSMUSG00000045225

Gene Name

olfactory receptor family 5 subfamily W member 19

Synonyms

Olfr1152, MOR177-12, GA_x6K02T2Q125-49372426-49373358

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.133) question?

Stock #

IGL03189

Quality Score

Status

Chromosome

Chromosomal Location

87698337-87699269 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 87698559 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 75 (A75T)

Ref Sequence

ENSEMBL: ENSMUSP00000151045 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051058] [ENSMUST00000213308]

AlphaFold

Q7TR34

Predicted Effect

possibly damaging
Transcript: ENSMUST00000051058
AA Change: A75T

PolyPhen 2 Score 0.762 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000054645
Gene: ENSMUSG00000045225
AA Change: A75T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	307	4e-46	PFAM
Pfam:7tm_1	40	290	1e-13	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121994

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213308
AA Change: A75T

PolyPhen 2 Score 0.762 (Sensitivity: 0.85; Specificity: 0.92)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	A	G	5: 8,895,814 (GRCm39)	T916A	probably benign	Het
Adam22	A	T	5: 8,161,897 (GRCm39)	Y50*	probably null	Het
Adprs	T	C	4: 126,211,087 (GRCm39)		probably benign	Het
Ahnak	G	A	19: 8,988,603 (GRCm39)	V3296M	possibly damaging	Het
Bfar	A	G	16: 13,505,365 (GRCm39)	D125G	possibly damaging	Het
Bmp3	A	T	5: 99,020,579 (GRCm39)	Q334L	probably benign	Het
Camsap2	A	T	1: 136,209,400 (GRCm39)	D697E	probably damaging	Het
Car11	A	G	7: 45,351,879 (GRCm39)	T103A	probably damaging	Het
Cecr2	T	A	6: 120,739,391 (GRCm39)	S1373T	probably benign	Het
Cenpm	A	G	15: 82,118,634 (GRCm39)	V160A	possibly damaging	Het
Chl1	A	T	6: 103,660,168 (GRCm39)	I365F	possibly damaging	Het
Col20a1	C	T	2: 180,651,200 (GRCm39)	Q1089*	probably null	Het
Csf1r	A	T	18: 61,239,058 (GRCm39)	T13S	probably benign	Het
Fam13a	T	C	6: 58,933,843 (GRCm39)	E249G	probably damaging	Het
Fgd6	G	A	10: 93,880,318 (GRCm39)	V391I	probably benign	Het
Fhdc1	G	A	3: 84,362,368 (GRCm39)		probably benign	Het
Fn3krp	T	C	11: 121,320,456 (GRCm39)	I267T	probably damaging	Het
Fras1	A	T	5: 96,890,930 (GRCm39)	I2820F	probably benign	Het
Fyb2	A	G	4: 104,872,939 (GRCm39)	I771V	probably damaging	Het
Gata3os	A	G	2: 9,888,634 (GRCm39)		probably benign	Het
Glis1	A	G	4: 107,472,248 (GRCm39)	Y275C	probably damaging	Het
Hdgf	A	G	3: 87,820,735 (GRCm39)	T62A	possibly damaging	Het
Hsd17b3	C	T	13: 64,210,901 (GRCm39)		probably null	Het
Ift56	C	T	6: 38,402,166 (GRCm39)	P553S	probably benign	Het
Iqgap1	T	A	7: 80,363,590 (GRCm39)	Y1655F	probably benign	Het
Izumo1	A	G	7: 45,274,588 (GRCm39)	D181G	probably damaging	Het
Lrp2	T	C	2: 69,268,822 (GRCm39)		probably benign	Het
Mark1	T	C	1: 184,651,890 (GRCm39)	N95S	probably damaging	Het
Mbd5	A	G	2: 49,147,763 (GRCm39)	K658E	probably damaging	Het
Mcm6	C	T	1: 128,272,039 (GRCm39)	D453N	probably damaging	Het
Mfsd14a	T	C	3: 116,435,504 (GRCm39)	D187G	probably benign	Het
Mrpl19	G	T	6: 81,938,974 (GRCm39)	S276*	probably null	Het
Ncoa2	G	A	1: 13,260,360 (GRCm39)	T105M	probably damaging	Het
Nop14	A	G	5: 34,807,972 (GRCm39)		probably benign	Het
Or2ah1	A	G	2: 85,653,902 (GRCm39)	T196A	probably benign	Het
Or2aj5	T	C	16: 19,425,341 (GRCm39)	T26A	probably benign	Het
Otud7b	G	A	3: 96,062,795 (GRCm39)	S678N	probably benign	Het
Pcdhb6	G	A	18: 37,469,205 (GRCm39)	V25M	probably damaging	Het
Prpf39	G	T	12: 65,090,076 (GRCm39)	G5*	probably null	Het
Serpinb9d	T	C	13: 33,386,895 (GRCm39)	V321A	probably damaging	Het
Sh2b1	A	G	7: 126,067,702 (GRCm39)	S613P	possibly damaging	Het
Snx30	T	C	4: 59,857,452 (GRCm39)	I55T	probably benign	Het
Spata13	T	C	14: 60,929,063 (GRCm39)	I207T	possibly damaging	Het
Suco	T	C	1: 161,684,906 (GRCm39)		probably benign	Het
Svs5	A	G	2: 164,079,032 (GRCm39)	S292P	possibly damaging	Het
Tcam1	A	G	11: 106,176,212 (GRCm39)	I313V	probably benign	Het
Tmem45a	A	T	16: 56,631,936 (GRCm39)	Y227*	probably null	Het
Tnfsf15	A	G	4: 63,648,289 (GRCm39)		probably benign	Het
Vmn2r4	C	A	3: 64,296,589 (GRCm39)	R732L	possibly damaging	Het
Wdr7	C	T	18: 63,893,672 (GRCm39)	T602I	probably benign	Het

Other mutations in Or5w19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01418:Or5w19	APN	2	87,698,809 (GRCm39)	missense	probably benign	0.00
IGL01618:Or5w19	APN	2	87,698,488 (GRCm39)	missense	probably damaging	0.96
IGL02326:Or5w19	APN	2	87,699,019 (GRCm39)	missense	probably damaging	1.00
IGL03162:Or5w19	APN	2	87,698,484 (GRCm39)	missense	probably benign	0.00
I2288:Or5w19	UTSW	2	87,698,479 (GRCm39)	missense	probably damaging	1.00
R0761:Or5w19	UTSW	2	87,698,880 (GRCm39)	missense	possibly damaging	0.88
R1558:Or5w19	UTSW	2	87,698,459 (GRCm39)	missense	probably damaging	1.00
R1938:Or5w19	UTSW	2	87,698,805 (GRCm39)	missense	probably benign	0.01
R3810:Or5w19	UTSW	2	87,698,745 (GRCm39)	missense	probably damaging	1.00
R3812:Or5w19	UTSW	2	87,698,745 (GRCm39)	missense	probably damaging	1.00
R4728:Or5w19	UTSW	2	87,698,779 (GRCm39)	missense	probably benign	0.13
R4928:Or5w19	UTSW	2	87,698,574 (GRCm39)	missense	probably benign	0.32
R5172:Or5w19	UTSW	2	87,699,171 (GRCm39)	missense	probably benign	0.20
R5174:Or5w19	UTSW	2	87,698,755 (GRCm39)	missense	possibly damaging	0.79
R6147:Or5w19	UTSW	2	87,699,061 (GRCm39)	missense	probably benign	0.03
R6195:Or5w19	UTSW	2	87,698,904 (GRCm39)	missense	possibly damaging	0.63
R6233:Or5w19	UTSW	2	87,698,904 (GRCm39)	missense	possibly damaging	0.63
R6541:Or5w19	UTSW	2	87,698,638 (GRCm39)	missense	probably benign	0.11
R7507:Or5w19	UTSW	2	87,698,713 (GRCm39)	missense	probably damaging	1.00
R8068:Or5w19	UTSW	2	87,698,995 (GRCm39)	missense	probably benign	0.20
R8407:Or5w19	UTSW	2	87,698,437 (GRCm39)	missense	probably damaging	1.00
R9110:Or5w19	UTSW	2	87,698,543 (GRCm39)	missense	probably damaging	1.00
R9408:Or5w19	UTSW	2	87,698,379 (GRCm39)	missense	probably damaging	1.00
R9797:Or5w19	UTSW	2	87,698,478 (GRCm39)	missense	possibly damaging	0.63

Posted On

2016-08-02