Incidental Mutation 'IGL03194:Map3k21'
ID 412741
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Map3k21
Ensembl Gene ENSMUSG00000031853
Gene Name mitogen-activated protein kinase kinase kinase 21
Synonyms BC021891
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # IGL03194
Quality Score
Status
Chromosome 8
Chromosomal Location 126637189-126674179 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 126650801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 268 (T268A)
Ref Sequence ENSEMBL: ENSMUSP00000034316 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034316]
AlphaFold Q8VDG6
Predicted Effect possibly damaging
Transcript: ENSMUST00000034316
AA Change: T268A

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000034316
Gene: ENSMUSG00000031853
AA Change: T268A

DomainStartEndE-ValueType
SH3 27 87 1.1e-18 SMART
TyrKc 110 382 6.04e-82 SMART
coiled coil region 402 474 N/A INTRINSIC
low complexity region 478 492 N/A INTRINSIC
low complexity region 661 677 N/A INTRINSIC
low complexity region 740 758 N/A INTRINSIC
low complexity region 766 788 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre5 T C 8: 84,460,647 (GRCm39) S64G possibly damaging Het
Clcn7 T C 17: 25,369,522 (GRCm39) V306A probably damaging Het
Clec4b2 G A 6: 123,177,946 (GRCm39) G87D probably benign Het
Disp2 A T 2: 118,618,110 (GRCm39) R219W probably damaging Het
Dnaaf11 A T 15: 66,314,048 (GRCm39) D317E probably benign Het
Dstyk A T 1: 132,384,054 (GRCm39) probably benign Het
F830045P16Rik T C 2: 129,302,240 (GRCm39) S451G possibly damaging Het
Fat2 T A 11: 55,201,821 (GRCm39) T418S probably benign Het
Fto G A 8: 92,136,415 (GRCm39) D228N probably damaging Het
Gins4 A T 8: 23,724,762 (GRCm39) probably benign Het
Gm10220 T A 5: 26,326,231 (GRCm39) R40W probably damaging Het
Gm11149 G A 9: 49,457,646 (GRCm39) probably benign Het
Gm5431 T G 11: 48,786,364 (GRCm39) probably benign Het
Hebp1 A G 6: 135,132,190 (GRCm39) M59T probably benign Het
Lrp1 A T 10: 127,404,554 (GRCm39) V1989D probably damaging Het
Ltc4s T C 11: 50,127,398 (GRCm39) *151W probably null Het
Mdp1 A G 14: 55,896,444 (GRCm39) L164P probably damaging Het
Mroh4 T C 15: 74,483,388 (GRCm39) T650A probably damaging Het
Mss51 T C 14: 20,535,165 (GRCm39) N202D probably benign Het
Mtus2 G A 5: 148,043,913 (GRCm39) A834T probably damaging Het
Nalf1 T C 8: 9,282,975 (GRCm39) D358G probably damaging Het
Ncoa6 A G 2: 155,257,788 (GRCm39) M585T possibly damaging Het
Nelfcd G A 2: 174,268,625 (GRCm39) A559T possibly damaging Het
Npvf A C 6: 50,627,878 (GRCm39) D180E possibly damaging Het
Nup188 A T 2: 30,194,346 (GRCm39) Y173F possibly damaging Het
Oas3 C A 5: 120,897,018 (GRCm39) A868S probably damaging Het
Pkhd1l1 A G 15: 44,381,531 (GRCm39) T1086A probably damaging Het
Pla2g6 G A 15: 79,201,985 (GRCm39) P62L probably damaging Het
Rara T C 11: 98,862,490 (GRCm39) M297T possibly damaging Het
Tmc1 T C 19: 20,782,017 (GRCm39) E567G probably damaging Het
Tnxb C T 17: 34,914,921 (GRCm39) Q1970* probably null Het
Usp11 T C X: 20,578,656 (GRCm39) I162T probably benign Het
Utrn A G 10: 12,282,173 (GRCm39) probably benign Het
Zfhx3 A G 8: 109,521,359 (GRCm39) E827G probably damaging Het
Other mutations in Map3k21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00494:Map3k21 APN 8 126,671,412 (GRCm39) missense possibly damaging 0.52
IGL01919:Map3k21 APN 8 126,668,871 (GRCm39) missense probably damaging 0.97
IGL02065:Map3k21 APN 8 126,668,397 (GRCm39) missense probably benign 0.01
IGL02123:Map3k21 APN 8 126,652,849 (GRCm39) missense probably damaging 1.00
IGL02127:Map3k21 APN 8 126,668,886 (GRCm39) missense probably benign
IGL02863:Map3k21 APN 8 126,654,280 (GRCm39) missense probably benign 0.02
PIT4142001:Map3k21 UTSW 8 126,664,047 (GRCm39) missense probably damaging 0.98
R0238:Map3k21 UTSW 8 126,671,709 (GRCm39) missense possibly damaging 0.67
R0238:Map3k21 UTSW 8 126,671,709 (GRCm39) missense possibly damaging 0.67
R0454:Map3k21 UTSW 8 126,668,858 (GRCm39) missense probably benign
R0654:Map3k21 UTSW 8 126,668,759 (GRCm39) missense probably benign 0.07
R1141:Map3k21 UTSW 8 126,668,471 (GRCm39) missense probably benign 0.32
R1177:Map3k21 UTSW 8 126,671,577 (GRCm39) missense probably benign 0.31
R1463:Map3k21 UTSW 8 126,668,876 (GRCm39) missense probably benign 0.00
R1472:Map3k21 UTSW 8 126,668,417 (GRCm39) missense probably benign
R1759:Map3k21 UTSW 8 126,671,519 (GRCm39) missense probably benign
R1988:Map3k21 UTSW 8 126,654,294 (GRCm39) missense probably benign 0.07
R2058:Map3k21 UTSW 8 126,665,461 (GRCm39) missense probably benign 0.01
R2117:Map3k21 UTSW 8 126,650,781 (GRCm39) missense probably benign 0.19
R2157:Map3k21 UTSW 8 126,664,005 (GRCm39) missense probably benign
R2436:Map3k21 UTSW 8 126,668,354 (GRCm39) nonsense probably null
R2507:Map3k21 UTSW 8 126,666,677 (GRCm39) missense possibly damaging 0.73
R3125:Map3k21 UTSW 8 126,668,593 (GRCm39) missense probably benign 0.26
R3746:Map3k21 UTSW 8 126,661,839 (GRCm39) missense probably damaging 1.00
R4016:Map3k21 UTSW 8 126,637,924 (GRCm39) missense probably damaging 1.00
R4647:Map3k21 UTSW 8 126,668,850 (GRCm39) missense probably benign
R4648:Map3k21 UTSW 8 126,668,850 (GRCm39) missense probably benign
R4864:Map3k21 UTSW 8 126,654,294 (GRCm39) missense probably benign 0.04
R5642:Map3k21 UTSW 8 126,665,563 (GRCm39) missense probably benign 0.17
R5694:Map3k21 UTSW 8 126,671,507 (GRCm39) missense probably benign 0.04
R5950:Map3k21 UTSW 8 126,668,499 (GRCm39) missense possibly damaging 0.93
R5982:Map3k21 UTSW 8 126,638,169 (GRCm39) missense probably damaging 1.00
R6440:Map3k21 UTSW 8 126,637,876 (GRCm39) missense probably damaging 1.00
R6550:Map3k21 UTSW 8 126,664,031 (GRCm39) missense probably damaging 1.00
R6664:Map3k21 UTSW 8 126,668,610 (GRCm39) missense probably benign 0.01
R6668:Map3k21 UTSW 8 126,652,852 (GRCm39) missense possibly damaging 0.60
R6788:Map3k21 UTSW 8 126,666,605 (GRCm39) missense probably benign 0.28
R7369:Map3k21 UTSW 8 126,637,855 (GRCm39) missense possibly damaging 0.86
R7371:Map3k21 UTSW 8 126,661,804 (GRCm39) missense probably damaging 0.99
R7381:Map3k21 UTSW 8 126,671,717 (GRCm39) missense possibly damaging 0.83
R7388:Map3k21 UTSW 8 126,654,336 (GRCm39) missense probably damaging 1.00
R7397:Map3k21 UTSW 8 126,661,855 (GRCm39) missense probably damaging 1.00
R7497:Map3k21 UTSW 8 126,654,340 (GRCm39) missense probably damaging 0.99
R7562:Map3k21 UTSW 8 126,665,539 (GRCm39) missense probably damaging 1.00
R7564:Map3k21 UTSW 8 126,654,447 (GRCm39) critical splice donor site probably null
R7824:Map3k21 UTSW 8 126,637,702 (GRCm39) missense probably benign 0.01
R8286:Map3k21 UTSW 8 126,637,498 (GRCm39) missense probably benign 0.00
R8351:Map3k21 UTSW 8 126,671,472 (GRCm39) missense probably benign 0.00
R8451:Map3k21 UTSW 8 126,671,472 (GRCm39) missense probably benign 0.00
R8461:Map3k21 UTSW 8 126,671,361 (GRCm39) missense probably benign 0.05
R9005:Map3k21 UTSW 8 126,637,471 (GRCm39) missense
R9074:Map3k21 UTSW 8 126,664,050 (GRCm39) missense probably damaging 0.98
R9156:Map3k21 UTSW 8 126,665,463 (GRCm39) missense possibly damaging 0.81
R9217:Map3k21 UTSW 8 126,638,027 (GRCm39) missense possibly damaging 0.47
R9474:Map3k21 UTSW 8 126,650,903 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02