Incidental Mutation 'IGL03194:Mtus2'
ID 412757
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mtus2
Ensembl Gene ENSMUSG00000029651
Gene Name microtubule associated tumor suppressor candidate 2
Synonyms C130038G02Rik, A730013O20Rik, 5730592G18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # IGL03194
Quality Score
Status
Chromosome 5
Chromosomal Location 147894130-148252875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 148043913 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 834 (A834T)
Ref Sequence ENSEMBL: ENSMUSP00000082694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085558]
AlphaFold Q3UHD3
Predicted Effect probably damaging
Transcript: ENSMUST00000085558
AA Change: A834T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000082694
Gene: ENSMUSG00000029651
AA Change: A834T

DomainStartEndE-ValueType
internal_repeat_1 57 290 2.46e-5 PROSPERO
internal_repeat_1 312 525 2.46e-5 PROSPERO
low complexity region 530 541 N/A INTRINSIC
low complexity region 802 818 N/A INTRINSIC
low complexity region 841 852 N/A INTRINSIC
low complexity region 893 904 N/A INTRINSIC
coiled coil region 1029 1080 N/A INTRINSIC
SCOP:d1fxkc_ 1167 1294 3e-4 SMART
low complexity region 1332 1349 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128423
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149336
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre5 T C 8: 84,460,647 (GRCm39) S64G possibly damaging Het
Clcn7 T C 17: 25,369,522 (GRCm39) V306A probably damaging Het
Clec4b2 G A 6: 123,177,946 (GRCm39) G87D probably benign Het
Disp2 A T 2: 118,618,110 (GRCm39) R219W probably damaging Het
Dnaaf11 A T 15: 66,314,048 (GRCm39) D317E probably benign Het
Dstyk A T 1: 132,384,054 (GRCm39) probably benign Het
F830045P16Rik T C 2: 129,302,240 (GRCm39) S451G possibly damaging Het
Fat2 T A 11: 55,201,821 (GRCm39) T418S probably benign Het
Fto G A 8: 92,136,415 (GRCm39) D228N probably damaging Het
Gins4 A T 8: 23,724,762 (GRCm39) probably benign Het
Gm10220 T A 5: 26,326,231 (GRCm39) R40W probably damaging Het
Gm11149 G A 9: 49,457,646 (GRCm39) probably benign Het
Gm5431 T G 11: 48,786,364 (GRCm39) probably benign Het
Hebp1 A G 6: 135,132,190 (GRCm39) M59T probably benign Het
Lrp1 A T 10: 127,404,554 (GRCm39) V1989D probably damaging Het
Ltc4s T C 11: 50,127,398 (GRCm39) *151W probably null Het
Map3k21 A G 8: 126,650,801 (GRCm39) T268A possibly damaging Het
Mdp1 A G 14: 55,896,444 (GRCm39) L164P probably damaging Het
Mroh4 T C 15: 74,483,388 (GRCm39) T650A probably damaging Het
Mss51 T C 14: 20,535,165 (GRCm39) N202D probably benign Het
Nalf1 T C 8: 9,282,975 (GRCm39) D358G probably damaging Het
Ncoa6 A G 2: 155,257,788 (GRCm39) M585T possibly damaging Het
Nelfcd G A 2: 174,268,625 (GRCm39) A559T possibly damaging Het
Npvf A C 6: 50,627,878 (GRCm39) D180E possibly damaging Het
Nup188 A T 2: 30,194,346 (GRCm39) Y173F possibly damaging Het
Oas3 C A 5: 120,897,018 (GRCm39) A868S probably damaging Het
Pkhd1l1 A G 15: 44,381,531 (GRCm39) T1086A probably damaging Het
Pla2g6 G A 15: 79,201,985 (GRCm39) P62L probably damaging Het
Rara T C 11: 98,862,490 (GRCm39) M297T possibly damaging Het
Tmc1 T C 19: 20,782,017 (GRCm39) E567G probably damaging Het
Tnxb C T 17: 34,914,921 (GRCm39) Q1970* probably null Het
Usp11 T C X: 20,578,656 (GRCm39) I162T probably benign Het
Utrn A G 10: 12,282,173 (GRCm39) probably benign Het
Zfhx3 A G 8: 109,521,359 (GRCm39) E827G probably damaging Het
Other mutations in Mtus2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01104:Mtus2 APN 5 148,013,819 (GRCm39) splice site probably null
IGL01911:Mtus2 APN 5 148,015,030 (GRCm39) missense probably benign 0.00
IGL01973:Mtus2 APN 5 148,240,286 (GRCm39) splice site probably benign
IGL02452:Mtus2 APN 5 148,014,473 (GRCm39) missense probably benign 0.01
IGL02476:Mtus2 APN 5 148,014,748 (GRCm39) missense probably benign 0.01
IGL02716:Mtus2 APN 5 148,173,120 (GRCm39) missense probably benign 0.05
rumblado UTSW 5 148,243,518 (GRCm39) nonsense probably null
IGL02991:Mtus2 UTSW 5 148,250,310 (GRCm39) missense probably damaging 1.00
PIT4431001:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0310:Mtus2 UTSW 5 148,043,829 (GRCm39) missense probably benign 0.17
R0729:Mtus2 UTSW 5 148,014,097 (GRCm39) missense probably benign 0.08
R0968:Mtus2 UTSW 5 148,014,994 (GRCm39) missense probably benign 0.09
R1231:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1253:Mtus2 UTSW 5 148,240,380 (GRCm39) nonsense probably null
R1556:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1561:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1574:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1750:Mtus2 UTSW 5 148,214,443 (GRCm39) missense probably damaging 0.97
R2318:Mtus2 UTSW 5 148,043,892 (GRCm39) nonsense probably null
R2327:Mtus2 UTSW 5 148,014,725 (GRCm39) missense probably benign 0.00
R3153:Mtus2 UTSW 5 148,019,870 (GRCm39) missense probably damaging 1.00
R3154:Mtus2 UTSW 5 148,240,083 (GRCm39) intron probably benign
R3158:Mtus2 UTSW 5 148,168,637 (GRCm39) missense probably damaging 1.00
R3548:Mtus2 UTSW 5 148,232,316 (GRCm39) missense probably damaging 1.00
R3861:Mtus2 UTSW 5 148,250,223 (GRCm39) missense probably damaging 1.00
R4395:Mtus2 UTSW 5 148,013,432 (GRCm39) missense probably benign 0.17
R4396:Mtus2 UTSW 5 148,140,748 (GRCm39) missense possibly damaging 0.81
R4667:Mtus2 UTSW 5 148,235,070 (GRCm39) missense possibly damaging 0.64
R4887:Mtus2 UTSW 5 148,013,913 (GRCm39) nonsense probably null
R4931:Mtus2 UTSW 5 148,014,226 (GRCm39) missense probably benign 0.09
R5097:Mtus2 UTSW 5 148,232,392 (GRCm39) missense probably damaging 0.99
R5318:Mtus2 UTSW 5 148,013,382 (GRCm39) missense probably benign 0.05
R5372:Mtus2 UTSW 5 148,250,222 (GRCm39) missense probably damaging 1.00
R5388:Mtus2 UTSW 5 148,243,518 (GRCm39) nonsense probably null
R5622:Mtus2 UTSW 5 148,015,244 (GRCm39) missense probably benign 0.09
R6009:Mtus2 UTSW 5 148,243,462 (GRCm39) missense probably damaging 1.00
R6379:Mtus2 UTSW 5 148,014,008 (GRCm39) missense probably benign 0.00
R6409:Mtus2 UTSW 5 148,014,425 (GRCm39) missense probably benign
R6527:Mtus2 UTSW 5 148,214,408 (GRCm39) critical splice acceptor site probably null
R6853:Mtus2 UTSW 5 148,043,821 (GRCm39) missense probably damaging 1.00
R7001:Mtus2 UTSW 5 148,214,438 (GRCm39) missense probably damaging 1.00
R7187:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R7276:Mtus2 UTSW 5 148,013,368 (GRCm39) missense probably benign
R7594:Mtus2 UTSW 5 148,014,216 (GRCm39) missense probably benign 0.44
R7790:Mtus2 UTSW 5 148,014,998 (GRCm39) missense probably benign 0.09
R7967:Mtus2 UTSW 5 148,014,656 (GRCm39) missense probably benign 0.32
R7987:Mtus2 UTSW 5 148,168,836 (GRCm39) splice site probably null
R8112:Mtus2 UTSW 5 148,013,713 (GRCm39) nonsense probably null
R8273:Mtus2 UTSW 5 148,043,815 (GRCm39) missense probably damaging 1.00
R8527:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8542:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8783:Mtus2 UTSW 5 148,019,861 (GRCm39) missense probably damaging 1.00
R8805:Mtus2 UTSW 5 148,015,303 (GRCm39) missense possibly damaging 0.58
R9204:Mtus2 UTSW 5 148,238,293 (GRCm39) missense probably damaging 1.00
R9210:Mtus2 UTSW 5 148,014,124 (GRCm39) missense probably benign 0.00
R9261:Mtus2 UTSW 5 148,243,453 (GRCm39) nonsense probably null
R9419:Mtus2 UTSW 5 148,243,451 (GRCm39) missense probably damaging 1.00
R9477:Mtus2 UTSW 5 148,014,740 (GRCm39) missense probably benign
R9483:Mtus2 UTSW 5 148,232,300 (GRCm39) missense possibly damaging 0.80
R9563:Mtus2 UTSW 5 148,250,217 (GRCm39) missense
R9643:Mtus2 UTSW 5 148,014,025 (GRCm39) missense probably benign 0.04
R9716:Mtus2 UTSW 5 148,013,464 (GRCm39) missense possibly damaging 0.82
R9745:Mtus2 UTSW 5 148,013,311 (GRCm39) missense possibly damaging 0.81
X0017:Mtus2 UTSW 5 148,214,410 (GRCm39) missense possibly damaging 0.83
X0028:Mtus2 UTSW 5 148,014,128 (GRCm39) missense probably benign 0.03
Z1088:Mtus2 UTSW 5 148,240,073 (GRCm39) intron probably benign
Z1176:Mtus2 UTSW 5 148,014,068 (GRCm39) missense probably benign 0.05
Z1176:Mtus2 UTSW 5 148,013,552 (GRCm39) missense probably benign 0.31
Z1177:Mtus2 UTSW 5 148,140,887 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02