Incidental Mutation 'IGL03195:Or2ag16'
ID 412764
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2ag16
Ensembl Gene ENSMUSG00000059087
Gene Name olfactory receptor family 2 subfamily AG member 16
Synonyms MOR283-3, GA_x6K02T2PBJ9-9130754-9129519, Olfr698
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # IGL03195
Quality Score
Status
Chromosome 7
Chromosomal Location 106351658-106352593 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106351980 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 205 (I205T)
Ref Sequence ENSEMBL: ENSMUSP00000149305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074981] [ENSMUST00000214306] [ENSMUST00000216255]
AlphaFold Q7TRN4
Predicted Effect probably benign
Transcript: ENSMUST00000074981
AA Change: I205T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074509
Gene: ENSMUSG00000059087
AA Change: I205T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 35 305 9.8e-8 PFAM
Pfam:7tm_1 41 290 4.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214306
AA Change: I205T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215892
Predicted Effect probably benign
Transcript: ENSMUST00000216255
AA Change: I205T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,903,607 (GRCm39) D1086G possibly damaging Het
Ahcyl2 T C 6: 29,906,768 (GRCm39) probably benign Het
Ankrd42 T A 7: 92,241,066 (GRCm39) Q431L probably benign Het
Arhgap12 A T 18: 6,031,766 (GRCm39) F592I probably damaging Het
Arhgef28 A G 13: 98,088,071 (GRCm39) probably null Het
Boc A G 16: 44,313,184 (GRCm39) F560S probably damaging Het
Ccdc81 A T 7: 89,545,916 (GRCm39) V96E probably benign Het
Cep162 C T 9: 87,107,839 (GRCm39) S517N probably benign Het
Cntnap5a A G 1: 116,085,178 (GRCm39) N372S probably benign Het
Dnah7a G A 1: 53,458,766 (GRCm39) R3791C probably damaging Het
Fdxr T C 11: 115,166,918 (GRCm39) Q57R probably benign Het
Fsip2l T A X: 47,961,825 (GRCm39) Q296L possibly damaging Het
G3bp2 A G 5: 92,216,367 (GRCm39) probably benign Het
Hmcn1 G A 1: 150,678,660 (GRCm39) T487I probably benign Het
Kpna7 A T 5: 144,933,847 (GRCm39) I282N probably damaging Het
Lif A T 11: 4,219,201 (GRCm39) Y160F probably damaging Het
Lrp1b A T 2: 41,361,134 (GRCm39) D556E possibly damaging Het
Myom2 G T 8: 15,161,844 (GRCm39) E954* probably null Het
Nr6a1 A T 2: 38,632,948 (GRCm39) I171N probably damaging Het
Nup210 C A 6: 90,992,832 (GRCm39) R1059L probably benign Het
Or11g27 A G 14: 50,770,877 (GRCm39) T3A probably benign Het
Or2w25 G A 11: 59,504,629 (GRCm39) V280M probably damaging Het
Or5ak4 A T 2: 85,161,864 (GRCm39) I126N probably damaging Het
Or5aq6 A T 2: 86,922,913 (GRCm39) V276E probably damaging Het
Ostm1 T C 10: 42,574,213 (GRCm39) V302A probably damaging Het
Oxct1 A G 15: 4,130,671 (GRCm39) M388V possibly damaging Het
Ppp6r2 G A 15: 89,152,758 (GRCm39) V300I possibly damaging Het
Prmt1 T C 7: 44,626,995 (GRCm39) Y205C probably damaging Het
Slc45a4 A C 15: 73,456,272 (GRCm39) V636G possibly damaging Het
Spata18 T A 5: 73,828,591 (GRCm39) L270Q probably damaging Het
Stard9 G A 2: 120,536,283 (GRCm39) D4151N probably damaging Het
Thsd7b G A 1: 129,556,646 (GRCm39) C334Y probably damaging Het
Tmtc3 C T 10: 100,294,896 (GRCm39) V406M probably benign Het
Trpc5 T A X: 143,165,724 (GRCm39) M900L probably benign Het
Ttc9c T C 19: 8,793,344 (GRCm39) K99E probably benign Het
Vmn1r73 A G 7: 11,491,007 (GRCm39) E275G probably damaging Het
Other mutations in Or2ag16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01373:Or2ag16 APN 7 106,351,653 (GRCm39) utr 3 prime probably benign
IGL01901:Or2ag16 APN 7 106,351,752 (GRCm39) missense possibly damaging 0.52
IGL01912:Or2ag16 APN 7 106,352,199 (GRCm39) missense probably damaging 1.00
IGL01998:Or2ag16 APN 7 106,351,758 (GRCm39) missense possibly damaging 0.63
IGL02640:Or2ag16 APN 7 106,352,559 (GRCm39) missense probably damaging 1.00
R0255:Or2ag16 UTSW 7 106,352,196 (GRCm39) missense probably benign 0.19
R1104:Or2ag16 UTSW 7 106,351,989 (GRCm39) missense probably benign 0.37
R1796:Or2ag16 UTSW 7 106,351,756 (GRCm39) missense probably benign 0.02
R1909:Or2ag16 UTSW 7 106,352,202 (GRCm39) missense probably benign 0.21
R4133:Or2ag16 UTSW 7 106,352,286 (GRCm39) missense probably damaging 0.98
R5194:Or2ag16 UTSW 7 106,352,426 (GRCm39) missense probably benign 0.15
R5389:Or2ag16 UTSW 7 106,352,290 (GRCm39) missense probably damaging 0.99
R5426:Or2ag16 UTSW 7 106,351,773 (GRCm39) missense probably benign
R6162:Or2ag16 UTSW 7 106,352,227 (GRCm39) missense probably damaging 1.00
R6463:Or2ag16 UTSW 7 106,352,008 (GRCm39) missense probably benign 0.23
R6643:Or2ag16 UTSW 7 106,351,776 (GRCm39) missense probably benign 0.41
R6831:Or2ag16 UTSW 7 106,351,778 (GRCm39) missense probably damaging 0.99
R6972:Or2ag16 UTSW 7 106,351,906 (GRCm39) missense possibly damaging 0.60
R7392:Or2ag16 UTSW 7 106,352,589 (GRCm39) missense possibly damaging 0.69
R7717:Or2ag16 UTSW 7 106,351,843 (GRCm39) missense possibly damaging 0.58
R7852:Or2ag16 UTSW 7 106,351,845 (GRCm39) missense probably damaging 0.98
R8073:Or2ag16 UTSW 7 106,352,008 (GRCm39) nonsense probably null
R8245:Or2ag16 UTSW 7 106,352,374 (GRCm39) missense probably benign 0.03
R8698:Or2ag16 UTSW 7 106,352,571 (GRCm39) missense probably benign 0.05
R9192:Or2ag16 UTSW 7 106,352,430 (GRCm39) missense probably damaging 1.00
R9333:Or2ag16 UTSW 7 106,351,782 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02