Incidental Mutation 'IGL03196:Or9g4b'
ID 412815
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or9g4b
Ensembl Gene ENSMUSG00000033850
Gene Name olfactory receptor family 9 subfamily G member 4B
Synonyms GA_x6K02T2Q125-47264151-47265089, Olfr1015, MOR213-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # IGL03196
Quality Score
Status
Chromosome 2
Chromosomal Location 85615818-85616833 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 85616365 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 170 (G170D)
Ref Sequence ENSEMBL: ENSMUSP00000148957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047870] [ENSMUST00000215945]
AlphaFold Q7TR94
Predicted Effect possibly damaging
Transcript: ENSMUST00000047870
AA Change: G170D

PolyPhen 2 Score 0.629 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000046301
Gene: ENSMUSG00000033850
AA Change: G170D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.5e-49 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214726
Predicted Effect possibly damaging
Transcript: ENSMUST00000215945
AA Change: G170D

PolyPhen 2 Score 0.629 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003E16Rik T C 6: 83,138,045 (GRCm39) V57A probably damaging Het
Adck1 T C 12: 88,397,885 (GRCm39) V173A probably damaging Het
Adgrv1 C A 13: 81,594,597 (GRCm39) R4139L probably benign Het
Aqp4 T G 18: 15,526,566 (GRCm39) D305A probably benign Het
Cadm1 T C 9: 47,710,675 (GRCm39) S193P possibly damaging Het
Ccdc88a T C 11: 29,432,340 (GRCm39) S377P possibly damaging Het
Clic5 C A 17: 44,552,960 (GRCm39) H71Q possibly damaging Het
Col20a1 G A 2: 180,649,671 (GRCm39) probably null Het
Col5a1 A G 2: 27,865,610 (GRCm39) D759G unknown Het
Cplane1 A T 15: 8,230,826 (GRCm39) K1034N probably damaging Het
Cpt1b A G 15: 89,308,598 (GRCm39) V110A probably benign Het
Cts8 C T 13: 61,401,272 (GRCm39) G85S probably benign Het
Cul5 T A 9: 53,537,180 (GRCm39) M551L probably damaging Het
Eno1b T A 18: 48,180,558 (GRCm39) D245E probably damaging Het
Fgf1 A T 18: 38,975,028 (GRCm39) Y140* probably null Het
Flt1 A G 5: 147,551,937 (GRCm39) probably null Het
Fndc7 A G 3: 108,790,760 (GRCm39) Y89H probably damaging Het
Gm3127 A T 14: 15,432,259 (GRCm39) M254L probably benign Het
Gm5849 T C 3: 90,685,089 (GRCm39) E32G probably damaging Het
Gys1 T C 7: 45,104,241 (GRCm39) probably benign Het
H2ap A G X: 9,713,349 (GRCm39) Q27R possibly damaging Het
Hdgfl2 T C 17: 56,400,607 (GRCm39) V125A probably benign Het
Igkv6-32 C T 6: 70,051,042 (GRCm39) V105I probably benign Het
Lmo3 T C 6: 138,342,993 (GRCm39) T140A probably benign Het
Marf1 A G 16: 13,958,123 (GRCm39) V793A possibly damaging Het
Mep1b A C 18: 21,228,121 (GRCm39) I575L probably benign Het
Mtmr4 T A 11: 87,491,609 (GRCm39) I155N possibly damaging Het
Muc2 T C 7: 141,301,367 (GRCm39) F361L probably damaging Het
Ncoa7 T A 10: 30,523,510 (GRCm39) probably benign Het
Nme6 C T 9: 109,670,561 (GRCm39) R71W probably damaging Het
Or56b1b T C 7: 108,164,061 (GRCm39) S314G probably benign Het
Or9m2 A T 2: 87,820,826 (GRCm39) I124F possibly damaging Het
Osbpl9 C T 4: 108,930,061 (GRCm39) V357I probably damaging Het
Ppp4r3a A G 12: 101,015,913 (GRCm39) probably benign Het
Rnf216 T C 5: 143,066,766 (GRCm39) R474G probably damaging Het
Rpp25l A G 4: 41,712,541 (GRCm39) V78A possibly damaging Het
Sh3bp2 C A 5: 34,714,687 (GRCm39) P245Q probably damaging Het
Slc33a1 A G 3: 63,871,151 (GRCm39) F154S possibly damaging Het
Wasf2 T A 4: 132,921,732 (GRCm39) S284T unknown Het
Wdtc1 T C 4: 133,022,648 (GRCm39) E566G probably damaging Het
Zcchc14 C T 8: 122,335,877 (GRCm39) probably benign Het
Other mutations in Or9g4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Or9g4b APN 2 85,616,461 (GRCm39) missense probably benign 0.21
IGL01716:Or9g4b APN 2 85,616,487 (GRCm39) missense probably damaging 0.97
IGL03374:Or9g4b APN 2 85,616,053 (GRCm39) missense probably damaging 1.00
R0329:Or9g4b UTSW 2 85,616,147 (GRCm39) nonsense probably null
R0330:Or9g4b UTSW 2 85,616,147 (GRCm39) nonsense probably null
R0714:Or9g4b UTSW 2 85,616,743 (GRCm39) missense probably damaging 1.00
R0965:Or9g4b UTSW 2 85,616,643 (GRCm39) missense probably damaging 1.00
R1078:Or9g4b UTSW 2 85,616,437 (GRCm39) missense possibly damaging 0.53
R3826:Or9g4b UTSW 2 85,616,559 (GRCm39) nonsense probably null
R5031:Or9g4b UTSW 2 85,616,062 (GRCm39) nonsense probably null
R5239:Or9g4b UTSW 2 85,616,002 (GRCm39) missense probably damaging 1.00
R6120:Or9g4b UTSW 2 85,616,685 (GRCm39) missense probably damaging 1.00
R6177:Or9g4b UTSW 2 85,616,004 (GRCm39) missense probably damaging 0.99
R6726:Or9g4b UTSW 2 85,615,906 (GRCm39) missense possibly damaging 0.51
R6954:Or9g4b UTSW 2 85,616,726 (GRCm39) nonsense probably null
R7766:Or9g4b UTSW 2 85,616,002 (GRCm39) missense probably damaging 1.00
R8193:Or9g4b UTSW 2 85,616,305 (GRCm39) missense probably benign 0.34
R8245:Or9g4b UTSW 2 85,616,119 (GRCm39) missense probably benign 0.02
R8339:Or9g4b UTSW 2 85,615,876 (GRCm39) missense probably damaging 0.98
R9272:Or9g4b UTSW 2 85,616,088 (GRCm39) missense probably benign 0.09
Z1176:Or9g4b UTSW 2 85,616,464 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02