Incidental Mutation 'IGL03202:Olfr525'
ID413019
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr525
Ensembl Gene ENSMUSG00000061489
Gene Nameolfactory receptor 525
SynonymsMOR251-2, GA_x6K02T2PBJ9-42472898-42473827
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #IGL03202
Quality Score
Status
Chromosome7
Chromosomal Location140320858-140327625 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 140323106 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 136 (M136V)
Ref Sequence ENSEMBL: ENSMUSP00000149361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078103] [ENSMUST00000214594]
Predicted Effect possibly damaging
Transcript: ENSMUST00000078103
AA Change: M136V

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000077243
Gene: ENSMUSG00000061489
AA Change: M136V

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 260 1.5e-5 PFAM
Pfam:7tm_1 41 290 1.3e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214594
AA Change: M136V

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215542
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik T C 10: 87,074,047 M1T probably null Het
2810474O19Rik G A 6: 149,326,439 V328I probably benign Het
Ace T A 11: 105,976,962 I168N probably damaging Het
Actr10 T G 12: 70,940,831 C37W probably damaging Het
Atp10b T C 11: 43,234,441 probably null Het
Bend5 A G 4: 111,433,244 N146D possibly damaging Het
Cacna1b A G 2: 24,651,112 F1347L probably damaging Het
Crybg3 T A 16: 59,494,709 I2910F probably damaging Het
Cspg4 T C 9: 56,897,739 S1945P possibly damaging Het
Cxcr4 T G 1: 128,588,904 K340T probably damaging Het
Dnah6 T A 6: 73,144,700 Y1433F probably damaging Het
Eif2ak4 T C 2: 118,400,620 V77A probably damaging Het
Fscn3 A T 6: 28,434,452 H342L probably benign Het
Gm884 T A 11: 103,615,373 E1923V probably benign Het
Gm9843 T C 16: 76,403,346 noncoding transcript Het
Hdac9 T C 12: 34,373,951 E520G probably damaging Het
Itm2b G A 14: 73,365,789 P120L probably damaging Het
Itpa T A 2: 130,667,939 probably benign Het
Lce1l A T 3: 92,850,324 C76S unknown Het
Lin54 A G 5: 100,475,814 S55P possibly damaging Het
Mtfmt C A 9: 65,448,726 P303Q probably damaging Het
Nae1 A T 8: 104,518,179 probably benign Het
Ncapd3 T A 9: 27,071,715 probably benign Het
Olfr381 G A 11: 73,486,525 Q100* probably null Het
Pcnx2 A C 8: 125,772,044 I1572S probably damaging Het
Piezo2 A T 18: 63,011,598 Y2809N probably damaging Het
Pygl G T 12: 70,199,646 Q376K probably benign Het
Rrp12 T C 19: 41,868,766 probably null Het
Sephs1 A T 2: 4,889,263 I92F possibly damaging Het
Taar4 T C 10: 23,960,794 F101L probably damaging Het
Tenm2 A G 11: 36,024,548 I2053T probably damaging Het
Tgfbr3 T G 5: 107,109,764 probably benign Het
Vmn2r108 A T 17: 20,471,057 Y401* probably null Het
Vmn2r87 A G 10: 130,497,222 M53T probably benign Het
Zfp941 A G 7: 140,813,053 V131A probably benign Het
Other mutations in Olfr525
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02143:Olfr525 APN 7 140323592 nonsense probably null
IGL02450:Olfr525 APN 7 140323227 missense possibly damaging 0.95
IGL02927:Olfr525 APN 7 140322741 missense probably damaging 1.00
IGL03008:Olfr525 APN 7 140323532 missense probably damaging 1.00
R0268:Olfr525 UTSW 7 140323155 missense possibly damaging 0.63
R0612:Olfr525 UTSW 7 140323188 missense possibly damaging 0.63
R0751:Olfr525 UTSW 7 140323325 missense probably benign
R0801:Olfr525 UTSW 7 140322918 missense probably damaging 1.00
R0940:Olfr525 UTSW 7 140323152 missense probably benign 0.01
R2220:Olfr525 UTSW 7 140323571 missense probably benign 0.03
R3748:Olfr525 UTSW 7 140323128 missense possibly damaging 0.87
R4660:Olfr525 UTSW 7 140323412 missense possibly damaging 0.67
R4683:Olfr525 UTSW 7 140322768 missense probably benign 0.01
R4887:Olfr525 UTSW 7 140323101 missense probably benign
R4919:Olfr525 UTSW 7 140323514 nonsense probably null
R5097:Olfr525 UTSW 7 140323095 missense probably damaging 1.00
R5836:Olfr525 UTSW 7 140322914 missense probably benign
R7024:Olfr525 UTSW 7 140322846 missense possibly damaging 0.75
Posted On2016-08-02