Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03210:Zfp455'

413266

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp455

Ensembl Gene

ENSMUSG00000051037

Gene Name

zinc finger protein 455

Synonyms

Rslcan-10, 3732412P20Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.356) question?

Stock #

IGL03210

Quality Score

Status

Chromosome

Chromosomal Location

67342570-67357362 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 67355113 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 127 (H127L)

Ref Sequence

ENSEMBL: ENSMUSP00000112546 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117110] [ENSMUST00000120861]

AlphaFold

Q7M6X9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000117110
AA Change: H62L

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000113356
Gene: ENSMUSG00000051037
AA Change: H62L

Domain	Start	End	E-Value	Type
ZnF_C2H2	44	66	7.15e-2	SMART
ZnF_C2H2	72	94	1.6e-4	SMART
ZnF_C2H2	100	122	2.12e-4	SMART
ZnF_C2H2	128	150	6.23e-2	SMART
ZnF_C2H2	184	206	1.01e-1	SMART
ZnF_C2H2	212	234	3.11e-2	SMART
ZnF_C2H2	240	262	1.1e-2	SMART
ZnF_C2H2	268	290	1.38e-3	SMART
ZnF_C2H2	296	318	3.58e-2	SMART
ZnF_C2H2	324	346	2.24e-3	SMART
ZnF_C2H2	352	374	7.9e-4	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000120861
AA Change: H127L

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000112546
Gene: ENSMUSG00000051037
AA Change: H127L

Domain	Start	End	E-Value	Type
KRAB	5	65	1.92e-34	SMART
ZnF_C2H2	109	131	7.15e-2	SMART
ZnF_C2H2	137	159	1.6e-4	SMART
ZnF_C2H2	165	187	2.12e-4	SMART
ZnF_C2H2	193	215	6.23e-2	SMART
ZnF_C2H2	249	271	1.01e-1	SMART
ZnF_C2H2	277	299	3.11e-2	SMART
ZnF_C2H2	305	327	1.1e-2	SMART
ZnF_C2H2	333	355	1.38e-3	SMART
ZnF_C2H2	361	383	3.58e-2	SMART
ZnF_C2H2	389	411	2.24e-3	SMART
ZnF_C2H2	417	439	7.9e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921539E11Rik	A	G	4: 103,141,635 (GRCm39)	F9L	probably benign	Het
Adora3	T	C	3: 105,815,176 (GRCm39)	S163P	probably benign	Het
Ark2c	C	A	18: 77,554,435 (GRCm39)	V60L	probably damaging	Het
C3	G	A	17: 57,522,846 (GRCm39)	Q1013*	probably null	Het
Cacna1b	A	T	2: 24,540,584 (GRCm39)	F1381Y	probably benign	Het
Dcdc2b	T	C	4: 129,505,578 (GRCm39)	K95R	probably benign	Het
Dnah8	A	G	17: 31,034,639 (GRCm39)	E4186G	probably damaging	Het
Dock1	T	C	7: 134,358,668 (GRCm39)	V374A	possibly damaging	Het
Gramd2b	A	G	18: 56,607,170 (GRCm39)	T95A	probably benign	Het
Grk2	C	T	19: 4,337,857 (GRCm39)	E508K	probably benign	Het
Hmgb4	A	G	4: 128,154,535 (GRCm39)	V11A	probably benign	Het
Knl1	G	A	2: 118,901,098 (GRCm39)	S933N	probably benign	Het
Ldlrad3	G	A	2: 101,900,271 (GRCm39)		probably benign	Het
Lrrc37a	T	A	11: 103,390,331 (GRCm39)	Y1698F	probably benign	Het
Ms4a14	A	G	19: 11,279,325 (GRCm39)	W1078R	possibly damaging	Het
Nol4l	G	A	2: 153,371,378 (GRCm39)	P102L	probably benign	Het
Nsun3	A	G	16: 62,591,110 (GRCm39)	F178L	probably damaging	Het
Nup85	T	A	11: 115,457,462 (GRCm39)	Y55N	probably benign	Het
Opcml	A	G	9: 28,812,833 (GRCm39)	E175G	probably damaging	Het
Or10a3m	T	A	7: 108,312,775 (GRCm39)	Y60N	probably damaging	Het
Or11g7	A	T	14: 50,691,440 (GRCm39)	R310S	probably benign	Het
Or9g4	T	C	2: 85,504,697 (GRCm39)	Y266C	probably damaging	Het
Pask	A	T	1: 93,247,714 (GRCm39)	W1074R	possibly damaging	Het
Pdzrn3	T	C	6: 101,133,913 (GRCm39)	T439A	possibly damaging	Het
Pkd1l1	C	A	11: 8,915,127 (GRCm39)	V138L	unknown	Het
Ptprj	C	A	2: 90,300,070 (GRCm39)	V244L	probably benign	Het
Rapgef5	A	G	12: 117,706,607 (GRCm39)	K697E	probably damaging	Het
Rp9	G	T	9: 22,368,724 (GRCm39)	H78Q	probably benign	Het
Serpinb8	A	G	1: 107,530,641 (GRCm39)	T140A	probably damaging	Het
Slc29a4	A	T	5: 142,700,863 (GRCm39)	M203L	probably damaging	Het
Stag1	T	A	9: 100,727,129 (GRCm39)	L363I	possibly damaging	Het
Susd1	T	G	4: 59,333,035 (GRCm39)		probably null	Het
Thoc3	A	T	13: 54,614,035 (GRCm39)	M196K	probably benign	Het
Tnr	A	G	1: 159,715,880 (GRCm39)	T881A	probably benign	Het
Ttbk2	A	G	2: 120,652,973 (GRCm39)	V17A	probably damaging	Het
Ttc41	T	A	10: 86,560,278 (GRCm39)		probably null	Het
Utp14b	A	G	1: 78,643,268 (GRCm39)	M389V	probably benign	Het
Utp4	T	A	8: 107,642,888 (GRCm39)	H515Q	probably benign	Het
Xpo1	A	G	11: 23,228,834 (GRCm39)	H223R	probably benign	Het
Xpot	A	G	10: 121,451,132 (GRCm39)		probably benign	Het
Zscan4e	T	A	7: 11,041,459 (GRCm39)	M166L	probably benign	Het

Other mutations in Zfp455

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00743:Zfp455	APN	13	67,355,962 (GRCm39)	missense	probably benign	0.33
IGL03111:Zfp455	APN	13	67,356,063 (GRCm39)	missense	probably benign	0.00
IGL03371:Zfp455	APN	13	67,355,066 (GRCm39)	nonsense	probably null
PIT4504001:Zfp455	UTSW	13	67,346,685 (GRCm39)	missense	probably damaging	0.98
R0245:Zfp455	UTSW	13	67,355,899 (GRCm39)	missense	probably damaging	1.00
R0277:Zfp455	UTSW	13	67,346,728 (GRCm39)	splice site	probably null
R1141:Zfp455	UTSW	13	67,346,655 (GRCm39)	missense	probably damaging	1.00
R1266:Zfp455	UTSW	13	67,355,028 (GRCm39)	nonsense	probably null
R1657:Zfp455	UTSW	13	67,346,703 (GRCm39)	missense	possibly damaging	0.83
R1749:Zfp455	UTSW	13	67,355,073 (GRCm39)	missense	probably damaging	1.00
R1757:Zfp455	UTSW	13	67,355,601 (GRCm39)	missense	probably damaging	1.00
R1854:Zfp455	UTSW	13	67,355,881 (GRCm39)	missense	probably damaging	1.00
R1867:Zfp455	UTSW	13	67,355,509 (GRCm39)	missense	probably benign	0.33
R4411:Zfp455	UTSW	13	67,355,389 (GRCm39)	missense	probably damaging	0.96
R6060:Zfp455	UTSW	13	67,355,257 (GRCm39)	missense	probably damaging	1.00
R6544:Zfp455	UTSW	13	67,355,121 (GRCm39)	missense	probably benign	0.33
R7132:Zfp455	UTSW	13	67,347,230 (GRCm39)	missense	probably damaging	1.00
R7524:Zfp455	UTSW	13	67,355,688 (GRCm39)	missense	possibly damaging	0.73
R7966:Zfp455	UTSW	13	67,347,302 (GRCm39)	missense	probably benign
R8848:Zfp455	UTSW	13	67,356,089 (GRCm39)	missense	possibly damaging	0.70
R8994:Zfp455	UTSW	13	67,355,478 (GRCm39)	missense	probably damaging	1.00
Z1176:Zfp455	UTSW	13	67,355,107 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02