Incidental Mutation 'IGL03212:Zfp942'
| ID |
413337 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp942
|
| Ensembl Gene |
ENSMUSG00000071267 |
| Gene Name |
zinc finger protein 942 |
| Synonyms |
3110048L19Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
IGL03212
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
22145941-22181445 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 22148445 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 61
(Y61*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000089494
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074295]
[ENSMUST00000091879]
|
| AlphaFold |
B8JJA7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000074295
AA Change: Y61*
|
| SMART Domains |
Protein: ENSMUSP00000073907
Gene: ENSMUSG00000071267
AA Change: Y61*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
69 |
6.55e-19 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.32e-1 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.99e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000091879
AA Change: Y61*
|
| SMART Domains |
Protein: ENSMUSP00000089494
Gene: ENSMUSG00000071267
AA Change: Y61*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
69 |
6.55e-19 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.32e-1 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.99e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Als2 |
A |
G |
1: 59,242,085 (GRCm39) |
S657P |
probably benign |
Het |
| Atp2c1 |
T |
A |
9: 105,322,466 (GRCm39) |
N221I |
probably damaging |
Het |
| Atp5pd |
G |
T |
11: 115,306,597 (GRCm39) |
H155N |
probably damaging |
Het |
| Cd55b |
A |
T |
1: 130,339,179 (GRCm39) |
N316K |
probably benign |
Het |
| Celsr1 |
A |
T |
15: 85,814,878 (GRCm39) |
M1861K |
probably benign |
Het |
| Cfap69 |
T |
G |
5: 5,707,849 (GRCm39) |
|
probably null |
Het |
| Col7a1 |
C |
A |
9: 108,803,520 (GRCm39) |
P2169Q |
unknown |
Het |
| Cyp2j5 |
G |
T |
4: 96,552,055 (GRCm39) |
H65N |
probably damaging |
Het |
| Dnah5 |
T |
C |
15: 28,290,309 (GRCm39) |
V1233A |
probably benign |
Het |
| Fn1 |
A |
T |
1: 71,680,484 (GRCm39) |
L407* |
probably null |
Het |
| Fpr-rs3 |
T |
C |
17: 20,844,121 (GRCm39) |
D340G |
probably benign |
Het |
| Fut2 |
C |
T |
7: 45,300,193 (GRCm39) |
G193E |
possibly damaging |
Het |
| Glmp |
T |
C |
3: 88,235,664 (GRCm39) |
S317P |
probably benign |
Het |
| Gm5581 |
A |
T |
6: 131,158,413 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5624 |
A |
T |
14: 44,798,167 (GRCm39) |
N103K |
probably benign |
Het |
| Gprin3 |
A |
G |
6: 59,332,013 (GRCm39) |
F98S |
probably benign |
Het |
| Ighmbp2 |
A |
G |
19: 3,329,942 (GRCm39) |
V104A |
probably damaging |
Het |
| Igkv4-79 |
A |
C |
6: 69,020,214 (GRCm39) |
S34A |
probably benign |
Het |
| Igsf10 |
G |
A |
3: 59,235,586 (GRCm39) |
P1532S |
probably benign |
Het |
| Myt1l |
A |
G |
12: 29,877,819 (GRCm39) |
K490R |
unknown |
Het |
| Or5d46 |
T |
A |
2: 88,170,016 (GRCm39) |
Y36N |
probably damaging |
Het |
| Pira13 |
T |
A |
7: 3,826,132 (GRCm39) |
Q287L |
probably benign |
Het |
| Plxna1 |
T |
A |
6: 89,308,885 (GRCm39) |
T1198S |
probably damaging |
Het |
| Pramel6 |
A |
G |
2: 87,340,769 (GRCm39) |
D367G |
probably damaging |
Het |
| Rbm28 |
G |
T |
6: 29,131,274 (GRCm39) |
R10S |
probably damaging |
Het |
| Rdh10 |
T |
G |
1: 16,178,051 (GRCm39) |
C108G |
probably benign |
Het |
| Rfx7 |
C |
A |
9: 72,526,443 (GRCm39) |
T1211K |
probably benign |
Het |
| Slc24a5 |
C |
A |
2: 124,922,750 (GRCm39) |
T141N |
probably damaging |
Het |
| Smarca5 |
T |
A |
8: 81,438,410 (GRCm39) |
N642I |
possibly damaging |
Het |
| Smchd1 |
C |
A |
17: 71,750,886 (GRCm39) |
R344L |
probably damaging |
Het |
| Tmx3 |
T |
A |
18: 90,556,642 (GRCm39) |
I355N |
probably damaging |
Het |
| Tram1l1 |
G |
A |
3: 124,115,563 (GRCm39) |
G241D |
possibly damaging |
Het |
| Ubr4 |
A |
G |
4: 139,137,074 (GRCm39) |
T982A |
probably benign |
Het |
| Vmn2r52 |
T |
G |
7: 9,893,474 (GRCm39) |
H555P |
possibly damaging |
Het |
| Zbtb43 |
A |
T |
2: 33,344,286 (GRCm39) |
M313K |
probably benign |
Het |
|
| Other mutations in Zfp942 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Zfp942
|
APN |
17 |
22,148,042 (GRCm39) |
missense |
probably benign |
|
|
IGL00586:Zfp942
|
APN |
17 |
22,147,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02973:Zfp942
|
APN |
17 |
22,151,972 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03382:Zfp942
|
APN |
17 |
22,148,083 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0008:Zfp942
|
UTSW |
17 |
22,147,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0113:Zfp942
|
UTSW |
17 |
22,148,066 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0244:Zfp942
|
UTSW |
17 |
22,147,553 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0369:Zfp942
|
UTSW |
17 |
22,148,017 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1664:Zfp942
|
UTSW |
17 |
22,147,420 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1824:Zfp942
|
UTSW |
17 |
22,147,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4545:Zfp942
|
UTSW |
17 |
22,147,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4785:Zfp942
|
UTSW |
17 |
22,148,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5493:Zfp942
|
UTSW |
17 |
22,151,985 (GRCm39) |
missense |
probably null |
0.66 |
|
R6568:Zfp942
|
UTSW |
17 |
22,148,043 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6733:Zfp942
|
UTSW |
17 |
22,147,733 (GRCm39) |
nonsense |
probably null |
|
|
R7650:Zfp942
|
UTSW |
17 |
22,147,818 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7935:Zfp942
|
UTSW |
17 |
22,148,208 (GRCm39) |
nonsense |
probably null |
|
|
R8065:Zfp942
|
UTSW |
17 |
22,149,391 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8067:Zfp942
|
UTSW |
17 |
22,149,391 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8237:Zfp942
|
UTSW |
17 |
22,147,226 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8513:Zfp942
|
UTSW |
17 |
22,147,282 (GRCm39) |
missense |
probably benign |
|
|
R9468:Zfp942
|
UTSW |
17 |
22,148,422 (GRCm39) |
missense |
probably benign |
0.24 |
|
R9539:Zfp942
|
UTSW |
17 |
22,148,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Zfp942
|
UTSW |
17 |
22,147,463 (GRCm39) |
missense |
probably benign |
0.05 |
|
X0025:Zfp942
|
UTSW |
17 |
22,148,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation