Incidental Mutation 'IGL03224:Meikin'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Meikin
Ensembl Gene ENSMUSG00000020332
Gene Namemeiotic kinetochore factor
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.199) question?
Stock #IGL03224
Quality Score
Chromosomal Location54370652-54426790 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 54398460 bp
Amino Acid Change Methionine to Valine at position 220 (M220V)
Ref Sequence ENSEMBL: ENSMUSP00000091745 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094193]
Predicted Effect probably benign
Transcript: ENSMUST00000094193
AA Change: M220V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000091745
Gene: ENSMUSG00000020332
AA Change: M220V

low complexity region 91 104 N/A INTRINSIC
low complexity region 361 386 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143919
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144172
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with defects in sister kinetochore pairing in meiosis I. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624J02Rik A G 7: 118,792,553 probably benign Het
Ash1l T C 3: 89,035,268 probably benign Het
Capn10 T G 1: 92,939,324 V92G probably damaging Het
Cntn2 A G 1: 132,523,042 C532R probably damaging Het
Csf1r T C 18: 61,112,062 F233L probably damaging Het
Cts6 T C 13: 61,201,733 D82G probably damaging Het
Cym T C 3: 107,218,732 S72G possibly damaging Het
Cyp4a29 T A 4: 115,247,050 M105K probably damaging Het
Dhx35 T C 2: 158,857,132 probably benign Het
Dnah5 C A 15: 28,459,154 D4506E probably damaging Het
Dok5 T C 2: 170,832,887 F139L possibly damaging Het
Dync2h1 T C 9: 7,076,235 D2974G probably benign Het
Frem3 C T 8: 80,613,463 T795I probably damaging Het
Ints6l A G X: 56,497,927 T525A probably damaging Het
Lrp1b T C 2: 41,471,031 T587A possibly damaging Het
Mmp12 T A 9: 7,350,002 probably benign Het
Mpp7 T C 18: 7,403,269 D347G probably benign Het
Myo3b A G 2: 70,349,939 Y1190C probably benign Het
Myo5c A G 9: 75,278,243 K963E probably benign Het
Nipbl T C 15: 8,293,085 D2614G probably damaging Het
Ppp1r3f A G X: 7,560,582 V480A probably benign Het
Prkcb A T 7: 122,516,924 K209* probably null Het
Rasgef1a A G 6: 118,089,806 probably benign Het
Ryr3 A T 2: 112,954,336 C233* probably null Het
Scn8a A G 15: 101,035,639 R1534G probably damaging Het
Slitrk3 A T 3: 73,049,930 L503H possibly damaging Het
Spag17 A G 3: 100,010,840 K380E possibly damaging Het
Spata31d1a A G 13: 59,701,026 V1096A possibly damaging Het
Synrg C T 11: 84,039,666 T1278M possibly damaging Het
Teddm1a G T 1: 153,892,017 V76F possibly damaging Het
Troap A G 15: 99,081,877 T365A probably benign Het
Other mutations in Meikin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Meikin APN 11 54398494 missense probably damaging 0.96
IGL02893:Meikin APN 11 54417758 missense possibly damaging 0.83
R0153:Meikin UTSW 11 54409642 splice site probably benign
R0634:Meikin UTSW 11 54390483 missense probably benign 0.22
R1374:Meikin UTSW 11 54398444 splice site probably benign
R1457:Meikin UTSW 11 54370941 nonsense probably null
R1659:Meikin UTSW 11 54390566 nonsense probably null
R1799:Meikin UTSW 11 54417787 missense probably benign 0.27
R2869:Meikin UTSW 11 54373507 missense possibly damaging 0.46
R2869:Meikin UTSW 11 54373507 missense possibly damaging 0.46
R3801:Meikin UTSW 11 54399871 synonymous probably null
R4384:Meikin UTSW 11 54417787 nonsense probably null
R6343:Meikin UTSW 11 54370766 missense probably damaging 0.97
R6523:Meikin UTSW 11 54398501 nonsense probably null
R6878:Meikin UTSW 11 54411886 missense possibly damaging 0.83
Posted On2016-08-02