Incidental Mutation 'IGL03225:Lrrc58'
ID 413772
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc58
Ensembl Gene ENSMUSG00000034158
Gene Name leucine rich repeat containing 58
Synonyms C330018J07Rik, 1810012N18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.183) question?
Stock # IGL03225
Quality Score
Status
Chromosome 16
Chromosomal Location 37688762-37709219 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 37701632 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 303 (C303W)
Ref Sequence ENSEMBL: ENSMUSP00000077779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078717]
AlphaFold Q3UGP9
Predicted Effect probably damaging
Transcript: ENSMUST00000078717
AA Change: C303W

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000077779
Gene: ENSMUSG00000034158
AA Change: C303W

DomainStartEndE-ValueType
LRR 39 61 1.12e2 SMART
LRR 62 85 3.02e0 SMART
LRR 114 136 1.33e2 SMART
LRR 137 159 1.16e-1 SMART
LRR 160 182 1.86e0 SMART
LRR 183 205 1.12e1 SMART
LRR_TYP 206 229 2.71e-2 SMART
low complexity region 327 354 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119947
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405O20Rik A G 7: 50,249,668 (GRCm39) K234R probably benign Het
Adam21 T C 12: 81,606,043 (GRCm39) E573G probably benign Het
Aox4 A T 1: 58,286,386 (GRCm39) I673F possibly damaging Het
Arfgef1 A T 1: 10,224,543 (GRCm39) I1431N probably damaging Het
Cask A G X: 13,531,760 (GRCm39) M103V possibly damaging Het
Clba1 T C 12: 112,779,211 (GRCm39) Y283H probably damaging Het
Fam83h T C 15: 75,875,150 (GRCm39) E729G probably damaging Het
Gnb4 T C 3: 32,641,881 (GRCm39) T249A probably damaging Het
Gpr12 A G 5: 146,520,761 (GRCm39) S54P probably damaging Het
Krt20 A G 11: 99,322,756 (GRCm39) V293A probably damaging Het
Lonrf1 A G 8: 36,689,855 (GRCm39) V706A probably damaging Het
Mbnl2 A G 14: 120,622,875 (GRCm39) T138A probably benign Het
Mss51 G A 14: 20,537,205 (GRCm39) R88* probably null Het
Nup214 T A 2: 31,924,423 (GRCm39) S146T probably damaging Het
Otop2 G A 11: 115,220,633 (GRCm39) R491H probably damaging Het
Podnl1 G A 8: 84,858,818 (GRCm39) V548I probably benign Het
Prkcz A T 4: 155,352,652 (GRCm39) F492I probably damaging Het
Sgtb T C 13: 104,268,453 (GRCm39) L163P probably damaging Het
Spsb3 T C 17: 25,110,045 (GRCm39) I365T possibly damaging Het
Tmem273 A G 14: 32,527,133 (GRCm39) I33M probably damaging Het
Trio T C 15: 27,902,781 (GRCm39) I227V probably benign Het
Vdac1 G A 11: 52,267,482 (GRCm39) R93H probably benign Het
Wasf2 A G 4: 132,903,857 (GRCm39) T22A probably benign Het
Other mutations in Lrrc58
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0744:Lrrc58 UTSW 16 37,698,935 (GRCm39) splice site probably benign
R2140:Lrrc58 UTSW 16 37,701,771 (GRCm39) missense probably damaging 1.00
R4995:Lrrc58 UTSW 16 37,697,418 (GRCm39) missense probably benign 0.02
R7438:Lrrc58 UTSW 16 37,689,053 (GRCm39) missense probably benign 0.33
R8459:Lrrc58 UTSW 16 37,698,872 (GRCm39) missense probably benign 0.04
R9219:Lrrc58 UTSW 16 37,689,180 (GRCm39) missense probably damaging 0.98
Posted On 2016-08-02