Incidental Mutation 'IGL03233:Gpr108'
ID413964
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr108
Ensembl Gene ENSMUSG00000005823
Gene NameG protein-coupled receptor 108
Synonyms1810015L19Rik
Accession Numbers

Genbank: NM_030084.3; Ensembl: ENSMUST00000005975

Is this an essential gene? Probably non essential (E-score: 0.231) question?
Stock #IGL03233
Quality Score
Status
Chromosome17
Chromosomal Location57234914-57247641 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 57245042 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 123 (I123F)
Ref Sequence ENSEMBL: ENSMUSP00000005975 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005975] [ENSMUST00000019631] [ENSMUST00000224152] [ENSMUST00000224885] [ENSMUST00000224947] [ENSMUST00000225664]
Predicted Effect probably benign
Transcript: ENSMUST00000005975
AA Change: I123F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000005975
Gene: ENSMUSG00000005823
AA Change: I123F

DomainStartEndE-ValueType
low complexity region 61 75 N/A INTRINSIC
low complexity region 86 103 N/A INTRINSIC
Pfam:Lung_7-TM_R 240 529 2.3e-98 PFAM
low complexity region 535 547 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000019631
SMART Domains Protein: ENSMUSP00000019631
Gene: ENSMUSG00000019487

DomainStartEndE-ValueType
FCH 1 94 9.95e-29 SMART
coiled coil region 117 197 N/A INTRINSIC
low complexity region 310 318 N/A INTRINSIC
PDB:2KE4|A 332 425 3e-35 PDB
low complexity region 433 455 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
SH3 489 546 2.44e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000224152
Predicted Effect probably benign
Transcript: ENSMUST00000224885
Predicted Effect probably benign
Transcript: ENSMUST00000224947
Predicted Effect probably benign
Transcript: ENSMUST00000225664
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(3) : Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 T C 4: 86,342,120 F856S probably damaging Het
Ak7 A G 12: 105,761,480 D457G probably damaging Het
Ankrd26 G T 6: 118,535,146 probably null Het
Ano5 C A 7: 51,570,368 P405T probably damaging Het
Asah2 T A 19: 32,054,631 N46I probably benign Het
Atg4c A T 4: 99,229,503 Y343F probably benign Het
Cab39 T A 1: 85,842,323 M175K probably benign Het
Cadps2 T C 6: 23,263,601 E1257G probably benign Het
Casc1 A T 6: 145,181,885 Y433N probably damaging Het
Ces1d A G 8: 93,195,079 Y19H probably benign Het
Cst6 T C 19: 5,349,261 D25G probably damaging Het
Cyp4a30b A T 4: 115,458,970 T298S probably benign Het
Dgkk T C X: 6,903,838 L352P probably damaging Het
Dync2h1 A C 9: 7,101,525 F482V possibly damaging Het
Esco1 A G 18: 10,574,877 W208R probably damaging Het
Fbn2 T C 18: 58,102,377 D676G probably benign Het
Foxp3 T C X: 7,587,423 probably benign Het
Gsdmc4 A T 15: 63,902,860 V24E probably damaging Het
Jam3 C A 9: 27,101,921 V118F probably damaging Het
Kif23 T A 9: 61,926,453 I489F probably benign Het
Lama3 T A 18: 12,481,038 V1288D probably damaging Het
Mark2 G T 19: 7,284,726 H308N possibly damaging Het
Mms19 T C 19: 41,946,913 probably null Het
Neb A T 2: 52,308,301 I477N possibly damaging Het
Npm1 G T 11: 33,156,717 Q204K probably benign Het
Nsun5 G A 5: 135,375,445 V369M probably damaging Het
Olfr1355 C A 10: 78,879,572 Y133* probably null Het
Pcdhb13 T A 18: 37,444,265 N565K probably damaging Het
Pla2r1 A G 2: 60,428,580 F1155L possibly damaging Het
Pus10 T A 11: 23,712,241 W304R probably damaging Het
Rab32 G A 10: 10,546,313 Q221* probably null Het
Rlf A G 4: 121,182,600 probably benign Het
Robo1 A T 16: 72,970,193 I418F probably damaging Het
Slc44a2 T C 9: 21,348,622 I642T possibly damaging Het
Ston2 T A 12: 91,647,853 T594S probably damaging Het
Szt2 T C 4: 118,372,529 T2802A unknown Het
Tshz3 T A 7: 36,770,079 Y498N probably damaging Het
Zfp280b T A 10: 76,039,769 I494N probably damaging Het
Zfp281 A G 1: 136,626,829 Q515R possibly damaging Het
Other mutations in Gpr108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01982:Gpr108 APN 17 57237877 missense probably damaging 1.00
IGL02486:Gpr108 APN 17 57235977 missense probably damaging 1.00
IGL02810:Gpr108 APN 17 57242742 missense probably benign 0.39
1mM(1):Gpr108 UTSW 17 57245352 unclassified probably benign
IGL02799:Gpr108 UTSW 17 57237482 missense probably damaging 1.00
PIT4468001:Gpr108 UTSW 17 57247563 missense probably null 0.09
R0391:Gpr108 UTSW 17 57243101 missense probably benign 0.02
R0469:Gpr108 UTSW 17 57235358 missense possibly damaging 0.65
R0510:Gpr108 UTSW 17 57235358 missense possibly damaging 0.65
R0613:Gpr108 UTSW 17 57238174 splice site probably benign
R1034:Gpr108 UTSW 17 57235995 missense probably damaging 1.00
R1141:Gpr108 UTSW 17 57237219 missense probably damaging 1.00
R1748:Gpr108 UTSW 17 57236217 missense probably damaging 0.99
R2000:Gpr108 UTSW 17 57236712 missense probably benign 0.03
R3036:Gpr108 UTSW 17 57245323 missense probably benign 0.01
R4087:Gpr108 UTSW 17 57237925 missense probably damaging 1.00
R4089:Gpr108 UTSW 17 57237925 missense probably damaging 1.00
R5071:Gpr108 UTSW 17 57235335 missense probably damaging 1.00
R5566:Gpr108 UTSW 17 57236919 missense probably damaging 1.00
R6889:Gpr108 UTSW 17 57236990 missense probably damaging 1.00
Posted On2016-08-02