Incidental Mutation 'IGL03236:Zfp768'
ID 414059
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp768
Ensembl Gene ENSMUSG00000047371
Gene Name zinc finger protein 768
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # IGL03236
Quality Score
Status
Chromosome 7
Chromosomal Location 126941967-126944486 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 126943142 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 329 (L329F)
Ref Sequence ENSEMBL: ENSMUSP00000145704 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060783] [ENSMUST00000205266]
AlphaFold Q8R0T2
Predicted Effect possibly damaging
Transcript: ENSMUST00000060783
AA Change: L332F

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000055374
Gene: ENSMUSG00000047371
AA Change: L332F

DomainStartEndE-ValueType
low complexity region 62 80 N/A INTRINSIC
Pfam:RNA_pol_Rpb1_R 112 130 3.7e-4 PFAM
Pfam:RNA_pol_Rpb1_R 133 152 1.3e-4 PFAM
low complexity region 271 288 N/A INTRINSIC
ZnF_C2H2 289 311 7.15e-2 SMART
ZnF_C2H2 317 339 1.22e-4 SMART
ZnF_C2H2 345 367 1.5e-4 SMART
ZnF_C2H2 373 395 4.3e-5 SMART
ZnF_C2H2 401 423 4.24e-4 SMART
ZnF_C2H2 429 451 9.58e-3 SMART
ZnF_C2H2 457 479 1.47e-3 SMART
ZnF_C2H2 485 507 7.49e-5 SMART
ZnF_C2H2 513 535 1.03e-2 SMART
ZnF_C2H2 541 563 6.52e-5 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000205266
AA Change: L329F

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm1 A G 4: 144,246,486 (GRCm39) T11A probably benign Het
Abca17 A G 17: 24,545,450 (GRCm39) probably benign Het
Aox1 G T 1: 58,349,156 (GRCm39) E641* probably null Het
Arhgef10l G T 4: 140,338,671 (GRCm39) D30E probably damaging Het
Arhgef37 A T 18: 61,656,897 (GRCm39) I56N probably damaging Het
Cwf19l1 T C 19: 44,115,887 (GRCm39) I181V probably benign Het
Dnai2 A G 11: 114,648,075 (GRCm39) probably benign Het
Elp2 A G 18: 24,755,300 (GRCm39) probably benign Het
Epb41l4a G A 18: 33,943,272 (GRCm39) S541L probably damaging Het
Ibsp A C 5: 104,453,871 (GRCm39) N70H probably benign Het
Ikzf1 A G 11: 11,657,848 (GRCm39) E35G probably damaging Het
Kdm5a T C 6: 120,415,949 (GRCm39) V1623A probably damaging Het
Kpna7 A T 5: 144,922,504 (GRCm39) V499E unknown Het
Krtap4-16 C A 11: 99,741,962 (GRCm39) R146L unknown Het
Map2k5 T A 9: 63,193,674 (GRCm39) probably benign Het
Mfn2 A G 4: 147,966,562 (GRCm39) F543S probably damaging Het
Mical3 A G 6: 120,946,345 (GRCm39) L1052P probably benign Het
Mycbp2 T C 14: 103,536,134 (GRCm39) N272S probably damaging Het
Ndel1 A G 11: 68,732,976 (GRCm39) Y87H probably benign Het
Ndnf G A 6: 65,673,156 (GRCm39) V45M possibly damaging Het
Nr3c1 A G 18: 39,619,444 (GRCm39) I281T probably benign Het
Ntm A G 9: 29,020,802 (GRCm39) V139A probably benign Het
Or5ac23 A C 16: 59,149,200 (GRCm39) V224G probably damaging Het
Pkhd1l1 T G 15: 44,445,222 (GRCm39) V3698G probably damaging Het
Plcb1 A G 2: 135,188,226 (GRCm39) Y773C probably damaging Het
Prkaca T A 8: 84,717,074 (GRCm39) F138Y probably damaging Het
Qser1 T C 2: 104,616,877 (GRCm39) T1312A probably benign Het
Slc47a2 T C 11: 61,204,505 (GRCm39) E282G probably damaging Het
Smchd1 G A 17: 71,698,425 (GRCm39) T1117I possibly damaging Het
Utp6 A G 11: 79,851,567 (GRCm39) probably benign Het
Vmn1r66 T A 7: 10,008,990 (GRCm39) K14N probably damaging Het
Vmn1r71 A T 7: 10,482,211 (GRCm39) V93E probably benign Het
Other mutations in Zfp768
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01153:Zfp768 APN 7 126,943,703 (GRCm39) missense possibly damaging 0.80
R1490:Zfp768 UTSW 7 126,942,803 (GRCm39) missense probably damaging 1.00
R1497:Zfp768 UTSW 7 126,942,733 (GRCm39) missense probably damaging 1.00
R2251:Zfp768 UTSW 7 126,943,550 (GRCm39) missense probably benign
R2298:Zfp768 UTSW 7 126,943,361 (GRCm39) missense probably benign 0.11
R2360:Zfp768 UTSW 7 126,943,810 (GRCm39) missense probably benign 0.43
R4751:Zfp768 UTSW 7 126,943,934 (GRCm39) missense possibly damaging 0.94
R4795:Zfp768 UTSW 7 126,942,547 (GRCm39) missense possibly damaging 0.60
R5011:Zfp768 UTSW 7 126,942,875 (GRCm39) missense probably damaging 1.00
R5518:Zfp768 UTSW 7 126,943,583 (GRCm39) missense probably benign
R5602:Zfp768 UTSW 7 126,943,804 (GRCm39) missense possibly damaging 0.73
R5876:Zfp768 UTSW 7 126,943,718 (GRCm39) missense probably benign 0.01
R6245:Zfp768 UTSW 7 126,943,263 (GRCm39) nonsense probably null
R6273:Zfp768 UTSW 7 126,944,319 (GRCm39) critical splice donor site probably null
R6376:Zfp768 UTSW 7 126,943,892 (GRCm39) missense probably benign 0.34
R6475:Zfp768 UTSW 7 126,943,827 (GRCm39) missense probably damaging 0.97
R7125:Zfp768 UTSW 7 126,943,959 (GRCm39) missense probably damaging 0.98
R7905:Zfp768 UTSW 7 126,943,831 (GRCm39) missense probably damaging 0.99
R8781:Zfp768 UTSW 7 126,942,476 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02