Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03237:Zfp128'

414095

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp128

Ensembl Gene

ENSMUSG00000060397

Gene Name

zinc finger protein 128

Synonyms

mZnf8, 9630016P15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

IGL03237

Quality Score

Status

Chromosome

Chromosomal Location

12615105-12627349 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 12624953 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 440 (E440D)

Ref Sequence

ENSEMBL: ENSMUSP00000115378 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000144578]

AlphaFold

Q8BGV5

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000081891

Predicted Effect

probably benign
Transcript: ENSMUST00000144578
AA Change: E440D

PolyPhen 2 Score 0.278 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000115378
Gene: ENSMUSG00000060397
AA Change: E440D

Domain	Start	End	E-Value	Type
KRAB	25	85	2.51e-38	SMART
ZnF_C2H2	254	276	8.47e-4	SMART
ZnF_C2H2	282	304	5.21e-4	SMART
ZnF_C2H2	310	332	4.17e-3	SMART
ZnF_C2H2	338	360	3.89e-3	SMART
ZnF_C2H2	366	388	1.47e-3	SMART
ZnF_C2H2	394	416	8.47e-4	SMART
ZnF_C2H2	464	486	3.39e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot12	A	G	13: 91,929,388 (GRCm39)	Y405C	probably benign	Het
Adam19	A	G	11: 46,028,383 (GRCm39)	K672R	probably benign	Het
Adamts7	C	A	9: 90,070,717 (GRCm39)	P613T	probably damaging	Het
Adgrl1	G	T	8: 84,656,312 (GRCm39)		probably null	Het
Adrb1	A	T	19: 56,711,800 (GRCm39)	N333Y	probably damaging	Het
Aqp7	C	T	4: 41,034,884 (GRCm39)	V190M	possibly damaging	Het
Atg101	T	C	15: 101,185,054 (GRCm39)	F59L	probably damaging	Het
Capn12	T	C	7: 28,590,366 (GRCm39)	S638P	probably damaging	Het
Ccm2l	T	C	2: 152,907,922 (GRCm39)		probably benign	Het
Cdc14a	A	T	3: 116,198,275 (GRCm39)		probably benign	Het
Cdh20	A	T	1: 110,066,037 (GRCm39)	K770N	possibly damaging	Het
Clxn	A	G	16: 14,738,652 (GRCm39)	D161G	probably damaging	Het
Col23a1	A	C	11: 51,458,746 (GRCm39)	E294D	possibly damaging	Het
Cped1	A	T	6: 22,233,595 (GRCm39)	Y679F	probably damaging	Het
Ctu2	A	G	8: 123,205,792 (GRCm39)	E180G	probably benign	Het
Cyp11b2	C	T	15: 74,722,914 (GRCm39)	V495I	probably benign	Het
Ecpas	A	T	4: 58,810,668 (GRCm39)	M1563K	probably benign	Het
Gabrg3	A	T	7: 56,632,460 (GRCm39)		probably null	Het
Hsd17b11	A	G	5: 104,151,036 (GRCm39)	*233Q	probably null	Het
Klhl41	T	C	2: 69,500,902 (GRCm39)	V121A	possibly damaging	Het
Kptn	A	T	7: 15,854,050 (GRCm39)	D56V	probably damaging	Het
L3mbtl4	T	A	17: 69,084,856 (GRCm39)	I589N	probably damaging	Het
Lpl	A	T	8: 69,347,378 (GRCm39)	N177Y	possibly damaging	Het
Manba	G	A	3: 135,250,512 (GRCm39)	V380M	probably damaging	Het
Mecom	A	T	3: 30,010,648 (GRCm39)		probably benign	Het
Mertk	A	G	2: 128,632,192 (GRCm39)	E707G	probably damaging	Het
Myo5a	A	T	9: 75,037,276 (GRCm39)	I160F	probably damaging	Het
Myo7a	A	T	7: 97,751,800 (GRCm39)	I81N	probably damaging	Het
Nelfcd	G	A	2: 174,268,625 (GRCm39)	A559T	possibly damaging	Het
Nipal1	C	T	5: 72,824,150 (GRCm39)	R76C	probably damaging	Het
Noc3l	C	T	19: 38,803,125 (GRCm39)		probably null	Het
Nt5e	A	G	9: 88,237,787 (GRCm39)	D239G	probably damaging	Het
Olr1	A	C	6: 129,479,117 (GRCm39)	W34G	probably damaging	Het
Plekhf1	A	T	7: 37,920,799 (GRCm39)	N256K	probably benign	Het
Psen2	T	C	1: 180,068,414 (GRCm39)	T80A	possibly damaging	Het
Psg27	A	G	7: 18,294,417 (GRCm39)	I330T	probably benign	Het
Ranbp2	T	C	10: 58,328,783 (GRCm39)	V2894A	probably damaging	Het
Sgcz	A	T	8: 38,030,332 (GRCm39)	D170E	probably benign	Het
Snrnp200	C	T	2: 127,075,233 (GRCm39)	A1573V	probably damaging	Het
Steap3	C	T	1: 120,171,520 (GRCm39)	G195D	probably damaging	Het
Tmem165	T	A	5: 76,347,356 (GRCm39)	Y5*	probably null	Het
Tnpo1	C	T	13: 99,000,348 (GRCm39)	E340K	probably damaging	Het
Vmn2r67	A	T	7: 84,799,118 (GRCm39)	C530S	probably damaging	Het
Wdfy3	T	A	5: 101,992,465 (GRCm39)	D3389V	probably damaging	Het

Other mutations in Zfp128

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Zfp128	APN	7	12,624,949 (GRCm39)	missense	probably benign	0.00
IGL01293:Zfp128	APN	7	12,625,351 (GRCm39)	makesense	probably null
IGL02067:Zfp128	APN	7	12,618,977 (GRCm39)	missense	possibly damaging	0.86
IGL02146:Zfp128	APN	7	12,623,959 (GRCm39)	missense	possibly damaging	0.72
IGL02654:Zfp128	APN	7	12,618,606 (GRCm39)	missense	possibly damaging	0.95
IGL03066:Zfp128	APN	7	12,624,044 (GRCm39)	missense	probably benign	0.00
IGL03076:Zfp128	APN	7	12,618,636 (GRCm39)	missense	possibly damaging	0.95
IGL03113:Zfp128	APN	7	12,624,314 (GRCm39)	missense	probably benign	0.00
prayer	UTSW	7	12,624,563 (GRCm39)	nonsense	probably null
R0783:Zfp128	UTSW	7	12,624,199 (GRCm39)	missense	probably damaging	1.00
R1686:Zfp128	UTSW	7	12,624,563 (GRCm39)	nonsense	probably null
R1806:Zfp128	UTSW	7	12,624,949 (GRCm39)	missense	probably benign	0.00
R2021:Zfp128	UTSW	7	12,623,956 (GRCm39)	missense	possibly damaging	0.96
R3792:Zfp128	UTSW	7	12,618,659 (GRCm39)	missense	probably damaging	0.98
R4105:Zfp128	UTSW	7	12,618,667 (GRCm39)	missense	probably damaging	0.99
R4167:Zfp128	UTSW	7	12,624,289 (GRCm39)	missense	probably benign	0.28
R4168:Zfp128	UTSW	7	12,624,289 (GRCm39)	missense	probably benign	0.28
R5743:Zfp128	UTSW	7	12,618,654 (GRCm39)	missense	probably damaging	1.00
R6266:Zfp128	UTSW	7	12,624,897 (GRCm39)	missense	possibly damaging	0.80
R6799:Zfp128	UTSW	7	12,624,826 (GRCm39)	missense	possibly damaging	0.93
R7102:Zfp128	UTSW	7	12,624,399 (GRCm39)	missense	probably damaging	1.00
R7313:Zfp128	UTSW	7	12,624,461 (GRCm39)	missense	possibly damaging	0.94
R7428:Zfp128	UTSW	7	12,624,289 (GRCm39)	missense	probably benign	0.28
R7504:Zfp128	UTSW	7	12,624,405 (GRCm39)	missense	probably damaging	0.99
R7539:Zfp128	UTSW	7	12,624,479 (GRCm39)	nonsense	probably null
R7636:Zfp128	UTSW	7	12,624,039 (GRCm39)	missense	probably benign
R7755:Zfp128	UTSW	7	12,624,240 (GRCm39)	nonsense	probably null
R7820:Zfp128	UTSW	7	12,624,949 (GRCm39)	missense	probably benign	0.00
R8269:Zfp128	UTSW	7	12,624,663 (GRCm39)	missense	probably damaging	1.00
R8932:Zfp128	UTSW	7	12,625,113 (GRCm39)	missense	possibly damaging	0.91
R9361:Zfp128	UTSW	7	12,624,364 (GRCm39)	missense	probably damaging	0.99
R9381:Zfp128	UTSW	7	12,624,897 (GRCm39)	missense	possibly damaging	0.80

Posted On

2016-08-02