Incidental Mutation 'IGL03237:Cdc14a'
ID 414114
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc14a
Ensembl Gene ENSMUSG00000033502
Gene Name CDC14 cell division cycle 14A
Synonyms A830059A17Rik, CDC14a1, CDC14A2, Cdc14
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # IGL03237
Quality Score
Status
Chromosome 3
Chromosomal Location 116066202-116222390 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 116198275 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142479 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090464] [ENSMUST00000106491] [ENSMUST00000197830]
AlphaFold Q6GQT0
Predicted Effect probably benign
Transcript: ENSMUST00000090464
SMART Domains Protein: ENSMUSP00000087950
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 13 153 1.6e-66 PFAM
Pfam:Y_phosphatase 210 324 1.1e-7 PFAM
Pfam:DSPc 214 328 1.8e-14 PFAM
low complexity region 539 558 N/A INTRINSIC
low complexity region 573 595 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106491
SMART Domains Protein: ENSMUSP00000102100
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 12 121 9.5e-44 PFAM
Pfam:Y_phosphatase 160 274 6.4e-8 PFAM
Pfam:DSPc 160 280 2.8e-14 PFAM
low complexity region 490 509 N/A INTRINSIC
low complexity region 524 546 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127704
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136994
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148857
Predicted Effect probably benign
Transcript: ENSMUST00000197830
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199454
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 A G 13: 91,929,388 (GRCm39) Y405C probably benign Het
Adam19 A G 11: 46,028,383 (GRCm39) K672R probably benign Het
Adamts7 C A 9: 90,070,717 (GRCm39) P613T probably damaging Het
Adgrl1 G T 8: 84,656,312 (GRCm39) probably null Het
Adrb1 A T 19: 56,711,800 (GRCm39) N333Y probably damaging Het
Aqp7 C T 4: 41,034,884 (GRCm39) V190M possibly damaging Het
Atg101 T C 15: 101,185,054 (GRCm39) F59L probably damaging Het
Capn12 T C 7: 28,590,366 (GRCm39) S638P probably damaging Het
Ccm2l T C 2: 152,907,922 (GRCm39) probably benign Het
Cdh20 A T 1: 110,066,037 (GRCm39) K770N possibly damaging Het
Clxn A G 16: 14,738,652 (GRCm39) D161G probably damaging Het
Col23a1 A C 11: 51,458,746 (GRCm39) E294D possibly damaging Het
Cped1 A T 6: 22,233,595 (GRCm39) Y679F probably damaging Het
Ctu2 A G 8: 123,205,792 (GRCm39) E180G probably benign Het
Cyp11b2 C T 15: 74,722,914 (GRCm39) V495I probably benign Het
Ecpas A T 4: 58,810,668 (GRCm39) M1563K probably benign Het
Gabrg3 A T 7: 56,632,460 (GRCm39) probably null Het
Hsd17b11 A G 5: 104,151,036 (GRCm39) *233Q probably null Het
Klhl41 T C 2: 69,500,902 (GRCm39) V121A possibly damaging Het
Kptn A T 7: 15,854,050 (GRCm39) D56V probably damaging Het
L3mbtl4 T A 17: 69,084,856 (GRCm39) I589N probably damaging Het
Lpl A T 8: 69,347,378 (GRCm39) N177Y possibly damaging Het
Manba G A 3: 135,250,512 (GRCm39) V380M probably damaging Het
Mecom A T 3: 30,010,648 (GRCm39) probably benign Het
Mertk A G 2: 128,632,192 (GRCm39) E707G probably damaging Het
Myo5a A T 9: 75,037,276 (GRCm39) I160F probably damaging Het
Myo7a A T 7: 97,751,800 (GRCm39) I81N probably damaging Het
Nelfcd G A 2: 174,268,625 (GRCm39) A559T possibly damaging Het
Nipal1 C T 5: 72,824,150 (GRCm39) R76C probably damaging Het
Noc3l C T 19: 38,803,125 (GRCm39) probably null Het
Nt5e A G 9: 88,237,787 (GRCm39) D239G probably damaging Het
Olr1 A C 6: 129,479,117 (GRCm39) W34G probably damaging Het
Plekhf1 A T 7: 37,920,799 (GRCm39) N256K probably benign Het
Psen2 T C 1: 180,068,414 (GRCm39) T80A possibly damaging Het
Psg27 A G 7: 18,294,417 (GRCm39) I330T probably benign Het
Ranbp2 T C 10: 58,328,783 (GRCm39) V2894A probably damaging Het
Sgcz A T 8: 38,030,332 (GRCm39) D170E probably benign Het
Snrnp200 C T 2: 127,075,233 (GRCm39) A1573V probably damaging Het
Steap3 C T 1: 120,171,520 (GRCm39) G195D probably damaging Het
Tmem165 T A 5: 76,347,356 (GRCm39) Y5* probably null Het
Tnpo1 C T 13: 99,000,348 (GRCm39) E340K probably damaging Het
Vmn2r67 A T 7: 84,799,118 (GRCm39) C530S probably damaging Het
Wdfy3 T A 5: 101,992,465 (GRCm39) D3389V probably damaging Het
Zfp128 A C 7: 12,624,953 (GRCm39) E440D probably benign Het
Other mutations in Cdc14a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Cdc14a APN 3 116,088,493 (GRCm39) nonsense probably null
IGL01062:Cdc14a APN 3 116,068,361 (GRCm39) splice site probably benign
IGL01584:Cdc14a APN 3 116,186,474 (GRCm39) nonsense probably null
IGL03084:Cdc14a APN 3 116,142,101 (GRCm39) critical splice donor site probably null
IGL03296:Cdc14a APN 3 116,090,807 (GRCm39) missense probably benign 0.02
PIT4131001:Cdc14a UTSW 3 116,122,310 (GRCm39) missense possibly damaging 0.66
R0707:Cdc14a UTSW 3 116,087,362 (GRCm39) splice site probably benign
R0782:Cdc14a UTSW 3 116,115,785 (GRCm39) missense probably damaging 1.00
R0835:Cdc14a UTSW 3 116,122,171 (GRCm39) missense probably benign 0.12
R1363:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R1507:Cdc14a UTSW 3 116,087,646 (GRCm39) missense possibly damaging 0.47
R1545:Cdc14a UTSW 3 116,087,373 (GRCm39) critical splice donor site probably null
R1795:Cdc14a UTSW 3 116,092,122 (GRCm39) missense possibly damaging 0.81
R1797:Cdc14a UTSW 3 116,115,843 (GRCm39) missense probably damaging 1.00
R1830:Cdc14a UTSW 3 116,216,296 (GRCm39) nonsense probably null
R4229:Cdc14a UTSW 3 116,087,413 (GRCm39) missense probably damaging 0.99
R4655:Cdc14a UTSW 3 116,122,136 (GRCm39) missense probably damaging 1.00
R4769:Cdc14a UTSW 3 116,088,399 (GRCm39) critical splice donor site probably null
R4870:Cdc14a UTSW 3 116,217,109 (GRCm39) missense probably benign 0.30
R4980:Cdc14a UTSW 3 116,186,506 (GRCm39) nonsense probably null
R6228:Cdc14a UTSW 3 116,144,862 (GRCm39) missense probably damaging 1.00
R6248:Cdc14a UTSW 3 116,101,843 (GRCm39) missense probably benign 0.01
R6402:Cdc14a UTSW 3 116,142,108 (GRCm39) missense probably damaging 1.00
R6749:Cdc14a UTSW 3 116,090,807 (GRCm39) missense possibly damaging 0.68
R6852:Cdc14a UTSW 3 116,122,325 (GRCm39) missense possibly damaging 0.94
R6996:Cdc14a UTSW 3 116,122,355 (GRCm39) missense probably damaging 1.00
R7185:Cdc14a UTSW 3 116,087,676 (GRCm39) missense probably benign
R7783:Cdc14a UTSW 3 116,198,236 (GRCm39) missense probably damaging 1.00
R7896:Cdc14a UTSW 3 116,088,482 (GRCm39) missense probably benign 0.00
R7991:Cdc14a UTSW 3 116,101,887 (GRCm39) missense probably benign 0.01
R8049:Cdc14a UTSW 3 116,087,577 (GRCm39) missense probably benign 0.33
R9163:Cdc14a UTSW 3 116,122,213 (GRCm39) missense possibly damaging 0.95
R9434:Cdc14a UTSW 3 116,217,092 (GRCm39) missense probably benign
R9526:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R9662:Cdc14a UTSW 3 116,088,484 (GRCm39) missense probably damaging 0.99
R9781:Cdc14a UTSW 3 116,122,274 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02