Incidental Mutation 'IGL03227:Zfp770'
| ID |
414128 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp770
|
| Ensembl Gene |
ENSMUSG00000040321 |
| Gene Name |
zinc finger protein 770 |
| Synonyms |
6430601A21Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.233)
|
| Stock # |
IGL03227
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
114023937-114031945 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 114027570 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 166
(C166*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052194
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050668]
|
| AlphaFold |
Q8BIQ8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000050668
AA Change: C166*
|
| SMART Domains |
Protein: ENSMUSP00000052194
Gene: ENSMUSG00000040321
AA Change: C166*
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
31 |
53 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
59 |
81 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
85 |
107 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
164 |
186 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
192 |
214 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
220 |
242 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
298 |
318 |
1.93e2 |
SMART |
|
low complexity region
|
341 |
354 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
485 |
507 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
513 |
535 |
1.82e-3 |
SMART |
|
low complexity region
|
576 |
595 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
640 |
662 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
668 |
690 |
7.37e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123562
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(4) : Targeted(3) Gene trapped(1)
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb3 |
C |
T |
1: 25,586,556 (GRCm39) |
G172E |
probably damaging |
Het |
| Alas2 |
A |
G |
X: 149,340,262 (GRCm39) |
K151E |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,066,089 (GRCm39) |
T4353A |
probably benign |
Het |
| Arhgef1 |
C |
A |
7: 24,622,276 (GRCm39) |
D554E |
probably damaging |
Het |
| Atad2b |
T |
A |
12: 5,056,715 (GRCm39) |
L857Q |
probably damaging |
Het |
| Atp2b4 |
C |
A |
1: 133,657,445 (GRCm39) |
|
probably benign |
Het |
| Bche |
C |
A |
3: 73,608,945 (GRCm39) |
K160N |
probably damaging |
Het |
| Bmx |
A |
G |
X: 162,986,192 (GRCm39) |
M537T |
probably damaging |
Het |
| Bysl |
T |
C |
17: 47,922,017 (GRCm39) |
N27S |
probably benign |
Het |
| Ccdc110 |
T |
A |
8: 46,394,586 (GRCm39) |
L159H |
probably damaging |
Het |
| Cd34 |
G |
A |
1: 194,640,771 (GRCm39) |
C212Y |
probably damaging |
Het |
| Erich2 |
C |
T |
2: 70,343,114 (GRCm39) |
|
probably benign |
Het |
| Fap |
T |
A |
2: 62,361,107 (GRCm39) |
|
probably null |
Het |
| Fitm2 |
T |
C |
2: 163,311,452 (GRCm39) |
T254A |
probably benign |
Het |
| Fscn3 |
T |
C |
6: 28,434,429 (GRCm39) |
S335P |
probably benign |
Het |
| Grk2 |
C |
T |
19: 4,337,857 (GRCm39) |
E508K |
probably benign |
Het |
| Lbr |
T |
C |
1: 181,663,620 (GRCm39) |
|
probably null |
Het |
| Lct |
A |
T |
1: 128,255,426 (GRCm39) |
F205L |
probably benign |
Het |
| Magi3 |
A |
T |
3: 103,958,435 (GRCm39) |
I550N |
probably benign |
Het |
| Med13 |
A |
G |
11: 86,218,618 (GRCm39) |
|
probably benign |
Het |
| Msh3 |
A |
T |
13: 92,422,468 (GRCm39) |
S563T |
probably damaging |
Het |
| Msra |
A |
G |
14: 64,551,192 (GRCm39) |
V50A |
probably benign |
Het |
| Or7g25 |
A |
G |
9: 19,160,518 (GRCm39) |
M59T |
probably damaging |
Het |
| Pcdhb13 |
T |
A |
18: 37,576,711 (GRCm39) |
V363E |
probably damaging |
Het |
| Piezo2 |
G |
A |
18: 63,257,677 (GRCm39) |
T347M |
probably damaging |
Het |
| Rapgef2 |
T |
C |
3: 78,999,920 (GRCm39) |
|
probably benign |
Het |
| Rtl9 |
A |
C |
X: 141,882,824 (GRCm39) |
T79P |
probably benign |
Het |
| Slc15a2 |
A |
G |
16: 36,576,410 (GRCm39) |
|
probably null |
Het |
| Slc51a |
G |
A |
16: 32,297,568 (GRCm39) |
R110C |
probably damaging |
Het |
| Smurf1 |
G |
T |
5: 144,835,992 (GRCm39) |
P123H |
probably damaging |
Het |
| Strn4 |
A |
G |
7: 16,571,639 (GRCm39) |
T590A |
possibly damaging |
Het |
| Trpm6 |
T |
C |
19: 18,796,483 (GRCm39) |
S780P |
probably benign |
Het |
| Trpm6 |
T |
C |
19: 18,764,143 (GRCm39) |
Y250H |
probably benign |
Het |
|
| Other mutations in Zfp770 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Zfp770
|
APN |
2 |
114,026,413 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL00478:Zfp770
|
APN |
2 |
114,027,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01539:Zfp770
|
APN |
2 |
114,027,574 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01778:Zfp770
|
APN |
2 |
114,026,719 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02596:Zfp770
|
APN |
2 |
114,026,308 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0057:Zfp770
|
UTSW |
2 |
114,027,713 (GRCm39) |
nonsense |
probably null |
|
|
R0057:Zfp770
|
UTSW |
2 |
114,027,713 (GRCm39) |
nonsense |
probably null |
|
|
R1081:Zfp770
|
UTSW |
2 |
114,027,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Zfp770
|
UTSW |
2 |
114,027,514 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4477:Zfp770
|
UTSW |
2 |
114,027,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4597:Zfp770
|
UTSW |
2 |
114,027,251 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4964:Zfp770
|
UTSW |
2 |
114,027,868 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4966:Zfp770
|
UTSW |
2 |
114,027,868 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5259:Zfp770
|
UTSW |
2 |
114,027,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5440:Zfp770
|
UTSW |
2 |
114,026,596 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5910:Zfp770
|
UTSW |
2 |
114,026,713 (GRCm39) |
nonsense |
probably null |
|
|
R5941:Zfp770
|
UTSW |
2 |
114,028,027 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6074:Zfp770
|
UTSW |
2 |
114,026,870 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6341:Zfp770
|
UTSW |
2 |
114,027,240 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7181:Zfp770
|
UTSW |
2 |
114,027,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7288:Zfp770
|
UTSW |
2 |
114,026,142 (GRCm39) |
nonsense |
probably null |
|
|
R7935:Zfp770
|
UTSW |
2 |
114,027,305 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8119:Zfp770
|
UTSW |
2 |
114,027,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8304:Zfp770
|
UTSW |
2 |
114,027,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9356:Zfp770
|
UTSW |
2 |
114,026,917 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9657:Zfp770
|
UTSW |
2 |
114,027,766 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9663:Zfp770
|
UTSW |
2 |
114,026,949 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2016-08-02 |
Incidental Mutation