Incidental Mutation 'IGL03227:Fscn3'
ID 414134
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fscn3
Ensembl Gene ENSMUSG00000029707
Gene Name fascin actin-bundling protein 3
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # IGL03227
Quality Score
Status
Chromosome 6
Chromosomal Location 28427888-28438621 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 28434429 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 335 (S335P)
Ref Sequence ENSEMBL: ENSMUSP00000031719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031719]
AlphaFold Q9QXW4
Predicted Effect probably benign
Transcript: ENSMUST00000031719
AA Change: S335P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000031719
Gene: ENSMUSG00000029707
AA Change: S335P

DomainStartEndE-ValueType
Pfam:Fascin 24 138 1e-29 PFAM
SCOP:d1dfca2 146 260 2e-48 SMART
Pfam:Fascin 271 381 2.1e-26 PFAM
SCOP:d1dfca4 386 498 3e-53 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147036
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 C T 1: 25,586,556 (GRCm39) G172E probably damaging Het
Alas2 A G X: 149,340,262 (GRCm39) K151E probably damaging Het
Apob A G 12: 8,066,089 (GRCm39) T4353A probably benign Het
Arhgef1 C A 7: 24,622,276 (GRCm39) D554E probably damaging Het
Atad2b T A 12: 5,056,715 (GRCm39) L857Q probably damaging Het
Atp2b4 C A 1: 133,657,445 (GRCm39) probably benign Het
Bche C A 3: 73,608,945 (GRCm39) K160N probably damaging Het
Bmx A G X: 162,986,192 (GRCm39) M537T probably damaging Het
Bysl T C 17: 47,922,017 (GRCm39) N27S probably benign Het
Ccdc110 T A 8: 46,394,586 (GRCm39) L159H probably damaging Het
Cd34 G A 1: 194,640,771 (GRCm39) C212Y probably damaging Het
Erich2 C T 2: 70,343,114 (GRCm39) probably benign Het
Fap T A 2: 62,361,107 (GRCm39) probably null Het
Fitm2 T C 2: 163,311,452 (GRCm39) T254A probably benign Het
Grk2 C T 19: 4,337,857 (GRCm39) E508K probably benign Het
Lbr T C 1: 181,663,620 (GRCm39) probably null Het
Lct A T 1: 128,255,426 (GRCm39) F205L probably benign Het
Magi3 A T 3: 103,958,435 (GRCm39) I550N probably benign Het
Med13 A G 11: 86,218,618 (GRCm39) probably benign Het
Msh3 A T 13: 92,422,468 (GRCm39) S563T probably damaging Het
Msra A G 14: 64,551,192 (GRCm39) V50A probably benign Het
Or7g25 A G 9: 19,160,518 (GRCm39) M59T probably damaging Het
Pcdhb13 T A 18: 37,576,711 (GRCm39) V363E probably damaging Het
Piezo2 G A 18: 63,257,677 (GRCm39) T347M probably damaging Het
Rapgef2 T C 3: 78,999,920 (GRCm39) probably benign Het
Rtl9 A C X: 141,882,824 (GRCm39) T79P probably benign Het
Slc15a2 A G 16: 36,576,410 (GRCm39) probably null Het
Slc51a G A 16: 32,297,568 (GRCm39) R110C probably damaging Het
Smurf1 G T 5: 144,835,992 (GRCm39) P123H probably damaging Het
Strn4 A G 7: 16,571,639 (GRCm39) T590A possibly damaging Het
Trpm6 T C 19: 18,796,483 (GRCm39) S780P probably benign Het
Trpm6 T C 19: 18,764,143 (GRCm39) Y250H probably benign Het
Zfp770 A T 2: 114,027,570 (GRCm39) C166* probably null Het
Other mutations in Fscn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01290:Fscn3 APN 6 28,430,505 (GRCm39) missense probably benign 0.43
IGL01312:Fscn3 APN 6 28,434,469 (GRCm39) missense probably damaging 0.99
IGL01634:Fscn3 APN 6 28,430,537 (GRCm39) missense probably damaging 1.00
IGL01899:Fscn3 APN 6 28,436,078 (GRCm39) missense probably damaging 1.00
IGL01928:Fscn3 APN 6 28,430,181 (GRCm39) missense possibly damaging 0.65
IGL02334:Fscn3 APN 6 28,428,153 (GRCm39) splice site probably null
IGL02959:Fscn3 APN 6 28,435,997 (GRCm39) missense possibly damaging 0.93
IGL03201:Fscn3 APN 6 28,430,604 (GRCm39) missense probably benign 0.07
IGL03202:Fscn3 APN 6 28,434,451 (GRCm39) missense probably benign 0.10
0152:Fscn3 UTSW 6 28,429,966 (GRCm39) unclassified probably benign
R1478:Fscn3 UTSW 6 28,430,567 (GRCm39) missense probably benign
R1502:Fscn3 UTSW 6 28,435,622 (GRCm39) missense probably benign 0.05
R1955:Fscn3 UTSW 6 28,430,235 (GRCm39) missense possibly damaging 0.82
R2122:Fscn3 UTSW 6 28,430,388 (GRCm39) missense probably benign 0.18
R2135:Fscn3 UTSW 6 28,431,583 (GRCm39) missense probably benign 0.02
R3713:Fscn3 UTSW 6 28,428,091 (GRCm39) missense possibly damaging 0.89
R3715:Fscn3 UTSW 6 28,428,091 (GRCm39) missense possibly damaging 0.89
R3778:Fscn3 UTSW 6 28,430,031 (GRCm39) missense possibly damaging 0.72
R4572:Fscn3 UTSW 6 28,430,634 (GRCm39) splice site probably null
R4745:Fscn3 UTSW 6 28,435,627 (GRCm39) missense probably damaging 0.98
R4764:Fscn3 UTSW 6 28,436,200 (GRCm39) makesense probably null
R4794:Fscn3 UTSW 6 28,430,595 (GRCm39) missense probably damaging 1.00
R5738:Fscn3 UTSW 6 28,430,030 (GRCm39) missense possibly damaging 0.56
R5951:Fscn3 UTSW 6 28,436,173 (GRCm39) missense possibly damaging 0.88
R5994:Fscn3 UTSW 6 28,430,294 (GRCm39) missense probably benign
R6595:Fscn3 UTSW 6 28,430,174 (GRCm39) missense probably damaging 1.00
R7323:Fscn3 UTSW 6 28,431,544 (GRCm39) missense possibly damaging 0.53
R7738:Fscn3 UTSW 6 28,434,445 (GRCm39) missense probably benign 0.01
R7840:Fscn3 UTSW 6 28,430,175 (GRCm39) missense probably damaging 1.00
R8169:Fscn3 UTSW 6 28,430,328 (GRCm39) missense possibly damaging 0.79
R8991:Fscn3 UTSW 6 28,434,472 (GRCm39) missense probably benign
R9111:Fscn3 UTSW 6 28,430,310 (GRCm39) missense probably damaging 0.98
R9350:Fscn3 UTSW 6 28,430,432 (GRCm39) nonsense probably null
R9370:Fscn3 UTSW 6 28,434,535 (GRCm39) missense probably benign
R9410:Fscn3 UTSW 6 28,430,432 (GRCm39) nonsense probably null
Posted On 2016-08-02