Incidental Mutation 'IGL03241:Trim75'
ID 414285
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim75
Ensembl Gene ENSMUSG00000071089
Gene Name tripartite motif-containing 75
Synonyms LOC333307
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # IGL03241
Quality Score
Status
Chromosome 8
Chromosomal Location 65434303-65440296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 65435358 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 364 (I364N)
Ref Sequence ENSEMBL: ENSMUSP00000092932 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095295] [ENSMUST00000210982]
AlphaFold Q3UWZ0
Predicted Effect probably damaging
Transcript: ENSMUST00000095295
AA Change: I364N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000092932
Gene: ENSMUSG00000071089
AA Change: I364N

DomainStartEndE-ValueType
RING 16 56 5.1e-11 SMART
BBOX 90 131 1.61e-8 SMART
coiled coil region 166 199 N/A INTRINSIC
PRY 293 344 2.12e-8 SMART
Pfam:SPRY 347 459 3.9e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210982
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 T A 8: 87,236,436 (GRCm39) E1126V possibly damaging Het
Acnat1 A G 4: 49,447,702 (GRCm39) V275A probably benign Het
Adamts15 G A 9: 30,815,781 (GRCm39) P692S probably damaging Het
Aqp7 A T 4: 41,045,270 (GRCm39) probably benign Het
Arhgap26 A T 18: 39,362,970 (GRCm39) I413F probably damaging Het
Cdc25a T C 9: 109,713,267 (GRCm39) probably null Het
Cdh18 C T 15: 23,227,019 (GRCm39) T160I probably benign Het
Cfap206 T C 4: 34,711,553 (GRCm39) Y448C probably damaging Het
Clec4a4 T C 6: 122,967,332 (GRCm39) S3P probably damaging Het
Dhx38 A T 8: 110,289,288 (GRCm39) H37Q possibly damaging Het
F7 A T 8: 13,078,779 (GRCm39) E70V probably damaging Het
Nbeal1 A T 1: 60,274,027 (GRCm39) Q418H possibly damaging Het
Nbeal1 G A 1: 60,274,028 (GRCm39) E419K probably benign Het
Nebl A G 2: 17,397,975 (GRCm39) probably null Het
Or4k15b T A 14: 50,272,525 (GRCm39) M112L possibly damaging Het
Pfkm T C 15: 98,021,061 (GRCm39) V293A probably benign Het
Slc36a3 A G 11: 55,015,934 (GRCm39) S407P possibly damaging Het
Slc5a1 T C 5: 33,290,749 (GRCm39) V111A probably benign Het
St6galnac5 G T 3: 152,552,223 (GRCm39) Q115K probably benign Het
Tex56 G T 13: 35,128,313 (GRCm39) A177S probably damaging Het
Timmdc1 G A 16: 38,331,071 (GRCm39) probably benign Het
Trim34b T C 7: 103,983,820 (GRCm39) probably benign Het
Vmn1r27 T A 6: 58,192,126 (GRCm39) N293Y probably benign Het
Vmn2r88 A G 14: 51,655,830 (GRCm39) T689A probably benign Het
Vmn2r97 T C 17: 19,148,438 (GRCm39) V111A probably benign Het
Zfp114 C T 7: 23,880,437 (GRCm39) T261I probably benign Het
Zfp516 A G 18: 83,005,645 (GRCm39) T850A probably benign Het
Other mutations in Trim75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01337:Trim75 APN 8 65,436,387 (GRCm39) missense possibly damaging 0.61
IGL02959:Trim75 APN 8 65,435,417 (GRCm39) missense possibly damaging 0.71
IGL03026:Trim75 APN 8 65,436,438 (GRCm39) missense probably benign 0.01
IGL03155:Trim75 APN 8 65,435,992 (GRCm39) missense possibly damaging 0.91
IGL03228:Trim75 APN 8 65,436,006 (GRCm39) missense probably benign 0.00
R0089:Trim75 UTSW 8 65,435,580 (GRCm39) missense possibly damaging 0.92
R0413:Trim75 UTSW 8 65,435,892 (GRCm39) missense probably benign 0.26
R0523:Trim75 UTSW 8 65,436,442 (GRCm39) missense probably benign 0.05
R1675:Trim75 UTSW 8 65,435,163 (GRCm39) missense probably damaging 0.99
R1721:Trim75 UTSW 8 65,435,391 (GRCm39) splice site probably null
R3861:Trim75 UTSW 8 65,435,479 (GRCm39) missense probably damaging 1.00
R4196:Trim75 UTSW 8 65,435,416 (GRCm39) missense probably damaging 1.00
R4469:Trim75 UTSW 8 65,436,369 (GRCm39) missense probably damaging 1.00
R4740:Trim75 UTSW 8 65,435,199 (GRCm39) missense probably damaging 1.00
R5049:Trim75 UTSW 8 65,435,091 (GRCm39) splice site probably null
R6046:Trim75 UTSW 8 65,435,535 (GRCm39) missense probably damaging 1.00
R6227:Trim75 UTSW 8 65,435,748 (GRCm39) missense probably benign 0.30
R6254:Trim75 UTSW 8 65,436,094 (GRCm39) nonsense probably null
R6444:Trim75 UTSW 8 65,435,488 (GRCm39) missense possibly damaging 0.88
R7363:Trim75 UTSW 8 65,435,539 (GRCm39) missense probably damaging 1.00
R7936:Trim75 UTSW 8 65,435,190 (GRCm39) missense probably damaging 1.00
R9328:Trim75 UTSW 8 65,435,315 (GRCm39) missense probably benign 0.06
R9453:Trim75 UTSW 8 65,436,561 (GRCm39) start gained probably benign
X0019:Trim75 UTSW 8 65,436,183 (GRCm39) missense probably benign 0.00
Z1177:Trim75 UTSW 8 65,435,593 (GRCm39) missense probably damaging 0.96
Z1177:Trim75 UTSW 8 65,435,313 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02