Incidental Mutation 'IGL03245:Micall2'
ID 414381
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Micall2
Ensembl Gene ENSMUSG00000036718
Gene Name MICAL-like 2
Synonyms MICAL-L2, Jrab, A930021H16Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.352) question?
Stock # IGL03245
Quality Score
Status
Chromosome 5
Chromosomal Location 139692451-139722091 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 139705014 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 107 (H107Y)
Ref Sequence ENSEMBL: ENSMUSP00000039707 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044642] [ENSMUST00000170773]
AlphaFold Q3TN34
Predicted Effect probably damaging
Transcript: ENSMUST00000044642
AA Change: H107Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000039707
Gene: ENSMUSG00000036718
AA Change: H107Y

DomainStartEndE-ValueType
CH 3 102 4.34e-20 SMART
LIM 187 241 1.62e-5 SMART
low complexity region 242 253 N/A INTRINSIC
low complexity region 326 344 N/A INTRINSIC
low complexity region 428 489 N/A INTRINSIC
low complexity region 502 518 N/A INTRINSIC
low complexity region 728 746 N/A INTRINSIC
low complexity region 755 770 N/A INTRINSIC
DUF3585 840 980 3.1e-63 SMART
Predicted Effect unknown
Transcript: ENSMUST00000170773
AA Change: H24Y
SMART Domains Protein: ENSMUSP00000127937
Gene: ENSMUSG00000036718
AA Change: H24Y

DomainStartEndE-ValueType
SCOP:d1bkra_ 1 25 9e-5 SMART
Blast:DUF3585 1 45 2e-7 BLAST
LIM 104 158 1.62e-5 SMART
low complexity region 159 170 N/A INTRINSIC
low complexity region 243 261 N/A INTRINSIC
low complexity region 345 406 N/A INTRINSIC
low complexity region 419 435 N/A INTRINSIC
low complexity region 645 663 N/A INTRINSIC
low complexity region 672 687 N/A INTRINSIC
DUF3585 757 897 3.1e-63 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 C T 7: 75,259,500 (GRCm39) A708V probably damaging Het
Cdh3 A G 8: 107,279,631 (GRCm39) N749S probably damaging Het
Col3a1 G A 1: 45,370,269 (GRCm39) probably benign Het
Csmd2 T A 4: 128,402,915 (GRCm39) S2334R probably benign Het
Cubn T C 2: 13,360,500 (GRCm39) T1741A probably benign Het
Cuedc1 T C 11: 88,068,088 (GRCm39) probably benign Het
Cutc T C 19: 43,756,621 (GRCm39) S228P possibly damaging Het
Dnmt1 G T 9: 20,827,056 (GRCm39) N1013K probably damaging Het
Dst G T 1: 34,250,229 (GRCm39) probably null Het
Lamc2 A T 1: 153,009,503 (GRCm39) probably null Het
Mettl25 T C 10: 105,662,358 (GRCm39) N204S possibly damaging Het
Or5d16 T A 2: 87,773,086 (GRCm39) R295S possibly damaging Het
Or8g28 T A 9: 39,169,294 (GRCm39) I225F probably damaging Het
Or9a7 A G 6: 40,521,076 (GRCm39) V279A probably damaging Het
Ptger4 A T 15: 5,264,588 (GRCm39) I331N probably damaging Het
Rad54l2 A G 9: 106,580,827 (GRCm39) F898S probably damaging Het
Smr2 A G 5: 88,256,709 (GRCm39) N129S probably benign Het
Tmeff2 T C 1: 51,220,976 (GRCm39) F317S probably benign Het
Trpm6 A T 19: 18,855,065 (GRCm39) E1908V probably damaging Het
Ugt2a3 G A 5: 87,484,439 (GRCm39) P195L probably damaging Het
Xpo7 T A 14: 70,925,734 (GRCm39) D436V probably damaging Het
Zfp804b C A 5: 6,822,253 (GRCm39) S234I possibly damaging Het
Other mutations in Micall2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Micall2 APN 5 139,703,311 (GRCm39) critical splice acceptor site probably null
IGL00496:Micall2 APN 5 139,702,083 (GRCm39) missense probably benign 0.01
IGL02641:Micall2 APN 5 139,705,094 (GRCm39) missense probably damaging 1.00
IGL03252:Micall2 APN 5 139,702,481 (GRCm39) missense probably benign 0.01
R1214:Micall2 UTSW 5 139,697,396 (GRCm39) missense probably damaging 0.97
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1831:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1833:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1969:Micall2 UTSW 5 139,721,885 (GRCm39) missense probably damaging 1.00
R2023:Micall2 UTSW 5 139,703,266 (GRCm39) missense possibly damaging 0.51
R2060:Micall2 UTSW 5 139,697,317 (GRCm39) missense probably damaging 0.98
R2330:Micall2 UTSW 5 139,703,270 (GRCm39) missense probably damaging 1.00
R3820:Micall2 UTSW 5 139,701,611 (GRCm39) missense possibly damaging 0.92
R4299:Micall2 UTSW 5 139,695,226 (GRCm39) intron probably benign
R4334:Micall2 UTSW 5 139,699,105 (GRCm39) missense probably damaging 1.00
R4451:Micall2 UTSW 5 139,692,852 (GRCm39) missense probably damaging 1.00
R4769:Micall2 UTSW 5 139,692,641 (GRCm39) missense probably damaging 0.97
R4911:Micall2 UTSW 5 139,702,580 (GRCm39) missense probably damaging 1.00
R4996:Micall2 UTSW 5 139,696,344 (GRCm39) missense probably benign 0.31
R5118:Micall2 UTSW 5 139,702,202 (GRCm39) missense probably damaging 1.00
R5155:Micall2 UTSW 5 139,695,986 (GRCm39) missense probably damaging 1.00
R5475:Micall2 UTSW 5 139,702,224 (GRCm39) missense probably damaging 1.00
R5750:Micall2 UTSW 5 139,701,456 (GRCm39) splice site probably null
R5998:Micall2 UTSW 5 139,692,666 (GRCm39) critical splice acceptor site probably null
R6181:Micall2 UTSW 5 139,702,506 (GRCm39) missense probably benign 0.41
R6852:Micall2 UTSW 5 139,701,548 (GRCm39) missense possibly damaging 0.90
R7046:Micall2 UTSW 5 139,694,699 (GRCm39) unclassified probably benign
R7395:Micall2 UTSW 5 139,702,124 (GRCm39) missense possibly damaging 0.78
R8514:Micall2 UTSW 5 139,701,977 (GRCm39) missense probably damaging 1.00
R8889:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8892:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8960:Micall2 UTSW 5 139,702,025 (GRCm39) missense probably benign 0.23
R9060:Micall2 UTSW 5 139,705,035 (GRCm39) missense probably damaging 1.00
R9209:Micall2 UTSW 5 139,696,170 (GRCm39) missense unknown
R9227:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9230:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9260:Micall2 UTSW 5 139,695,453 (GRCm39) missense unknown
R9452:Micall2 UTSW 5 139,703,311 (GRCm39) critical splice acceptor site probably null
Z1088:Micall2 UTSW 5 139,702,050 (GRCm39) missense probably benign 0.12
Z1088:Micall2 UTSW 5 139,692,649 (GRCm39) missense probably damaging 1.00
Z1177:Micall2 UTSW 5 139,696,057 (GRCm39) missense unknown
Posted On 2016-08-02