Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03247:Ifna2'

414423

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna2

Ensembl Gene

ENSMUSG00000078354

Gene Name

interferon alpha 2

Synonyms

Ifa2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL03247

Quality Score

Status

Chromosome

Chromosomal Location

88601444-88602016 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 88601614 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 135 (T135S)

Ref Sequence

ENSEMBL: ENSMUSP00000100778 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105147]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000105147
AA Change: T135S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000100778
Gene: ENSMUSG00000078354
AA Change: T135S

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	1.24e-70	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy4	T	A	14: 56,007,553 (GRCm39)	I926F	probably damaging	Het
Agap3	A	G	5: 24,692,820 (GRCm39)	N418D	probably damaging	Het
Alms1	T	C	6: 85,655,579 (GRCm39)	V3375A	possibly damaging	Het
Ankrd6	T	A	4: 32,860,441 (GRCm39)	M1L	possibly damaging	Het
Aox4	A	G	1: 58,303,526 (GRCm39)	D1188G	probably damaging	Het
Car2	T	A	3: 14,952,999 (GRCm39)	L47Q	probably damaging	Het
Catsper2	A	G	2: 121,240,681 (GRCm39)	V107A	probably benign	Het
Catsperg2	T	C	7: 29,416,473 (GRCm39)	N313S	possibly damaging	Het
Dolk	T	C	2: 30,175,523 (GRCm39)	Y174C	probably damaging	Het
Erfe	A	G	1: 91,298,147 (GRCm39)	E219G	probably benign	Het
Ern2	T	C	7: 121,770,894 (GRCm39)	E733G	probably benign	Het
Fam228a	A	G	12: 4,787,734 (GRCm39)	F13S	probably damaging	Het
Fancd2	T	C	6: 113,545,169 (GRCm39)	V829A	probably benign	Het
Gid4	C	A	11: 60,323,169 (GRCm39)	T87N	probably benign	Het
H2-Ob	A	G	17: 34,462,466 (GRCm39)	K152R	probably benign	Het
Il1rapl2	G	A	X: 137,690,429 (GRCm39)	G298D	probably damaging	Het
Mbd1	T	A	18: 74,407,825 (GRCm39)	L174*	probably null	Het
Mga	T	A	2: 119,765,994 (GRCm39)	D1341E	possibly damaging	Het
Mmp12	T	A	9: 7,348,631 (GRCm39)	M54K	probably benign	Het
Mphosph8	T	A	14: 56,916,277 (GRCm39)		probably null	Het
Mrps23	A	G	11: 88,100,922 (GRCm39)		probably benign	Het
Necab1	C	T	4: 14,960,046 (GRCm39)	M300I	probably benign	Het
Nid2	G	A	14: 19,829,688 (GRCm39)	D660N	probably damaging	Het
Or2ag12	T	A	7: 106,276,754 (GRCm39)	H313L	probably benign	Het
Or9r7	T	A	10: 129,962,584 (GRCm39)	E114V	probably damaging	Het
P2ry13	A	T	3: 59,117,013 (GRCm39)	V255D	possibly damaging	Het
Peak1	C	T	9: 56,165,214 (GRCm39)	E905K	probably damaging	Het
Picalm	C	A	7: 89,843,499 (GRCm39)	Q550K	probably benign	Het
Rnf103	T	A	6: 71,487,289 (GRCm39)	V640E	possibly damaging	Het
Sec31b	T	G	19: 44,507,379 (GRCm39)	K817N	possibly damaging	Het
Shisal2a	A	T	4: 108,225,098 (GRCm39)	C155S	probably benign	Het
Skint2	C	A	4: 112,483,223 (GRCm39)	H209Q	probably benign	Het
Skint5	T	C	4: 113,798,005 (GRCm39)	S193G	probably damaging	Het
Tacr3	A	G	3: 134,635,852 (GRCm39)		probably benign	Het
Tek	A	G	4: 94,753,680 (GRCm39)	M1041V	possibly damaging	Het
Tm4sf1	A	G	3: 57,200,436 (GRCm39)	S89P	possibly damaging	Het
Tusc3	T	A	8: 39,597,931 (GRCm39)	N299K	possibly damaging	Het
Washc4	T	C	10: 83,400,327 (GRCm39)	S418P	probably benign	Het

Other mutations in Ifna2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01882:Ifna2	APN	4	88,601,979 (GRCm39)	missense	possibly damaging	0.87
PIT4687001:Ifna2	UTSW	4	88,601,542 (GRCm39)	missense	possibly damaging	0.92
R0691:Ifna2	UTSW	4	88,601,895 (GRCm39)	missense	probably damaging	1.00
R1305:Ifna2	UTSW	4	88,601,614 (GRCm39)	missense	probably benign	0.00
R6470:Ifna2	UTSW	4	88,601,751 (GRCm39)	missense	probably benign	0.01
R7886:Ifna2	UTSW	4	88,601,506 (GRCm39)	missense	probably damaging	1.00
R8560:Ifna2	UTSW	4	88,601,502 (GRCm39)	missense	possibly damaging	0.93
R8931:Ifna2	UTSW	4	88,601,712 (GRCm39)	missense	probably benign	0.30
R9037:Ifna2	UTSW	4	88,601,664 (GRCm39)	missense	probably benign	0.11
X0013:Ifna2	UTSW	4	88,601,771 (GRCm39)	missense	probably benign

Posted On

2016-08-02