Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03255:Gm10220'

414618

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm10220

Ensembl Gene

ENSMUSG00000067698

Gene Name

predicted gene 10220

Synonyms

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.437) question?

Stock #

IGL03255

Quality Score

Status

Chromosome

Chromosomal Location

26319762-26326419 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 26321899 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 258 (S258P)

Ref Sequence

ENSEMBL: ENSMUSP00000085569 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088236]

AlphaFold

K7N660

Predicted Effect

possibly damaging
Transcript: ENSMUST00000088236
AA Change: S258P

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000085569
Gene: ENSMUSG00000067698
AA Change: S258P

Domain	Start	End	E-Value	Type
Pfam:Takusan	50	134	1.6e-25	PFAM
low complexity region	235	259	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600012P17Rik	A	G	1: 158,796,921 (GRCm39)		noncoding transcript	Het
Alpk3	A	G	7: 80,742,310 (GRCm39)	D709G	probably benign	Het
Capn3	G	T	2: 120,320,189 (GRCm39)	R309L	probably damaging	Het
Card11	T	C	5: 140,884,086 (GRCm39)	I398V	possibly damaging	Het
Cps1	T	A	1: 67,184,960 (GRCm39)	Y162*	probably null	Het
Defa26	A	T	8: 22,108,257 (GRCm39)	D20V	probably damaging	Het
Defa39	T	C	8: 22,193,534 (GRCm39)	T29A	possibly damaging	Het
Dnah8	T	G	17: 30,960,355 (GRCm39)	L2244R	probably damaging	Het
Fhad1	T	A	4: 141,700,191 (GRCm39)	N353I	possibly damaging	Het
Flt1	T	A	5: 147,525,331 (GRCm39)		probably benign	Het
Glyr1	G	A	16: 4,866,621 (GRCm39)		probably null	Het
Lama3	A	T	18: 12,672,760 (GRCm39)	D845V	probably damaging	Het
Myh2	T	A	11: 67,084,051 (GRCm39)	L1558Q	probably damaging	Het
Nelfb	G	T	2: 25,093,207 (GRCm39)	H482N	probably benign	Het
Or5ae1	T	C	7: 84,565,725 (GRCm39)	L246P	possibly damaging	Het
Or5p58	A	G	7: 107,694,024 (GRCm39)	V251A	probably damaging	Het
Ppfia2	A	G	10: 106,732,368 (GRCm39)	T972A	possibly damaging	Het
Slc5a4a	G	A	10: 75,986,346 (GRCm39)	V85M	probably damaging	Het
Slc6a12	T	G	6: 121,331,246 (GRCm39)	C166G	probably damaging	Het
Tm7sf3	T	C	6: 146,507,618 (GRCm39)		probably benign	Het
Tmem94	G	T	11: 115,682,894 (GRCm39)		probably benign	Het
Tmod2	T	C	9: 75,484,540 (GRCm39)		probably benign	Het
Tmprss11c	T	A	5: 86,419,341 (GRCm39)	I73F	probably damaging	Het
Vmn1r10	A	G	6: 57,090,911 (GRCm39)	M168V	probably benign	Het
Vmn2r77	T	A	7: 86,461,131 (GRCm39)	M819K	probably benign	Het
Vmo1	C	T	11: 70,405,236 (GRCm39)		probably null	Het
Ywhab	A	G	2: 163,855,936 (GRCm39)	D104G	probably benign	Het

Other mutations in Gm10220

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00401:Gm10220	APN	5	26,323,609 (GRCm39)	missense	possibly damaging	0.94
IGL01782:Gm10220	APN	5	26,322,021 (GRCm39)	missense	probably damaging	1.00
IGL03194:Gm10220	APN	5	26,326,231 (GRCm39)	missense	probably damaging	1.00
IGL03218:Gm10220	APN	5	26,323,696 (GRCm39)	missense	probably damaging	0.99
R3014:Gm10220	UTSW	5	26,322,826 (GRCm39)	missense	probably damaging	0.99
R3883:Gm10220	UTSW	5	26,321,908 (GRCm39)	missense	possibly damaging	0.70
R4577:Gm10220	UTSW	5	26,322,869 (GRCm39)	missense	probably benign
R5484:Gm10220	UTSW	5	26,322,930 (GRCm39)	missense	possibly damaging	0.59
R6358:Gm10220	UTSW	5	26,325,303 (GRCm39)	splice site	probably null
R8300:Gm10220	UTSW	5	26,322,818 (GRCm39)	missense	probably damaging	0.99
R8871:Gm10220	UTSW	5	26,322,863 (GRCm39)	missense	probably benign	0.01

Posted On

2016-08-02