Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03257:Zfp618'

414701

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp618

Ensembl Gene

ENSMUSG00000028358

Gene Name

zinc finger protein 618

Synonyms

Nedd10, 2810040O04Rik, D430033D05Rik, 2810031P15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

IGL03257

Quality Score

Status

Chromosome

Chromosomal Location

62883810-63057945 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 63050908 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 563 (Y563C)

Ref Sequence

ENSEMBL: ENSMUSP00000103038 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064814] [ENSMUST00000107415]

AlphaFold

Q80YY7

Predicted Effect

probably damaging
Transcript: ENSMUST00000064814
AA Change: Y470C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000069275
Gene: ENSMUSG00000028358
AA Change: Y470C

Domain	Start	End	E-Value	Type
ZnF_C2H2	114	136	5.06e-2	SMART
ZnF_C2H2	155	177	8.81e-2	SMART
ZnF_C2H2	243	265	2.91e-2	SMART
low complexity region	288	295	N/A	INTRINSIC
ZnF_C2H2	298	320	2.53e-2	SMART
PDB:2BW3\|A	377	690	5e-8	PDB

Predicted Effect

probably damaging
Transcript: ENSMUST00000107415
AA Change: Y563C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000103038
Gene: ENSMUSG00000028358
AA Change: Y563C

Domain	Start	End	E-Value	Type
ZnF_C2H2	146	168	5.06e-2	SMART
ZnF_C2H2	187	209	8.81e-2	SMART
ZnF_C2H2	255	277	2.91e-2	SMART
low complexity region	381	388	N/A	INTRINSIC
ZnF_C2H2	391	413	2.53e-2	SMART
PDB:2BW3\|A	479	783	9e-8	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	C	A	14: 118,852,623 (GRCm39)	V489L	probably benign	Het
Alpk2	C	A	18: 65,482,945 (GRCm39)	E354D	probably damaging	Het
Ank1	A	T	8: 23,612,914 (GRCm39)	K1060M	probably damaging	Het
Cand2	A	G	6: 115,776,944 (GRCm39)	N1111D	possibly damaging	Het
Ccny	A	T	18: 9,386,747 (GRCm39)	S73T	possibly damaging	Het
Clps	T	C	17: 28,779,634 (GRCm39)		probably benign	Het
Cnga1	C	A	5: 72,768,205 (GRCm39)	W160C	probably damaging	Het
Col6a5	T	C	9: 105,759,072 (GRCm39)	S2045G	possibly damaging	Het
Dennd4a	T	G	9: 64,779,156 (GRCm39)	N546K	possibly damaging	Het
Efcab5	A	T	11: 77,079,596 (GRCm39)	M50K	probably damaging	Het
Fntb	A	G	12: 76,934,805 (GRCm39)	H228R	probably damaging	Het
Gm4787	C	T	12: 81,424,826 (GRCm39)	C444Y	probably damaging	Het
Gpm6a	A	G	8: 55,490,507 (GRCm39)	Y61C	probably damaging	Het
Grm5	T	A	7: 87,252,106 (GRCm39)	S119T	possibly damaging	Het
Igf1r	T	A	7: 67,864,688 (GRCm39)	I1162N	probably damaging	Het
Irx5	A	G	8: 93,087,258 (GRCm39)	T397A	probably benign	Het
Kdm1b	C	T	13: 47,202,742 (GRCm39)	T59M	probably damaging	Het
Lrrc9	T	A	12: 72,496,542 (GRCm39)	S57T	probably benign	Het
Nup210l	A	T	3: 90,087,455 (GRCm39)		probably null	Het
Or5p52	T	C	7: 107,501,963 (GRCm39)	I13T	probably benign	Het
Or8k27	A	T	2: 86,276,234 (GRCm39)	F31I	probably damaging	Het
Prl8a1	A	G	13: 27,759,656 (GRCm39)	I127T	probably damaging	Het
Psme1	T	C	14: 55,818,086 (GRCm39)	I142T	probably damaging	Het
Ptbp3	A	T	4: 59,493,370 (GRCm39)		probably benign	Het
Rnf20	T	A	4: 49,645,687 (GRCm39)	N321K	probably benign	Het
Ttc23	T	C	7: 67,361,126 (GRCm39)	S340P	probably damaging	Het
Txnrd1	A	T	10: 82,721,105 (GRCm39)	K393I	probably benign	Het
Zfp365	A	T	10: 67,724,868 (GRCm39)	F340Y	possibly damaging	Het
Zfp451	C	A	1: 33,816,129 (GRCm39)	R607L	possibly damaging	Het

Other mutations in Zfp618

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01301:Zfp618	APN	4	63,051,063 (GRCm39)	missense	probably damaging	1.00
IGL01563:Zfp618	APN	4	62,998,133 (GRCm39)	missense	probably benign	0.38
IGL01726:Zfp618	APN	4	63,050,872 (GRCm39)	missense	probably damaging	1.00
IGL02139:Zfp618	APN	4	63,051,773 (GRCm39)	missense	probably damaging	1.00
IGL02182:Zfp618	APN	4	63,013,798 (GRCm39)	splice site	probably benign
IGL02533:Zfp618	APN	4	63,007,642 (GRCm39)	missense	probably damaging	1.00
IGL03231:Zfp618	APN	4	63,012,716 (GRCm39)	missense	probably damaging	1.00
ANU18:Zfp618	UTSW	4	63,051,063 (GRCm39)	missense	probably damaging	1.00
IGL03014:Zfp618	UTSW	4	62,998,325 (GRCm39)	missense	probably damaging	1.00
R0288:Zfp618	UTSW	4	63,051,171 (GRCm39)	missense	possibly damaging	0.57
R0408:Zfp618	UTSW	4	63,004,809 (GRCm39)	missense	probably damaging	0.97
R0685:Zfp618	UTSW	4	63,052,011 (GRCm39)	missense	probably benign	0.21
R1482:Zfp618	UTSW	4	63,033,685 (GRCm39)	missense	possibly damaging	0.64
R1585:Zfp618	UTSW	4	63,051,175 (GRCm39)	missense	probably damaging	1.00
R1649:Zfp618	UTSW	4	63,013,774 (GRCm39)	missense	probably damaging	1.00
R1744:Zfp618	UTSW	4	63,004,871 (GRCm39)	splice site	probably benign
R1793:Zfp618	UTSW	4	63,051,474 (GRCm39)	missense	probably damaging	0.97
R1952:Zfp618	UTSW	4	63,050,555 (GRCm39)	splice site	probably null
R1996:Zfp618	UTSW	4	63,049,452 (GRCm39)	splice site	probably null
R3792:Zfp618	UTSW	4	63,033,728 (GRCm39)	intron	probably benign
R3803:Zfp618	UTSW	4	63,051,256 (GRCm39)	missense	probably damaging	1.00
R3821:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R3838:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4009:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4010:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4565:Zfp618	UTSW	4	63,039,588 (GRCm39)	missense	probably damaging	1.00
R4611:Zfp618	UTSW	4	63,051,216 (GRCm39)	missense	probably damaging	1.00
R5019:Zfp618	UTSW	4	63,021,789 (GRCm39)	missense	probably damaging	1.00
R5154:Zfp618	UTSW	4	63,051,446 (GRCm39)	missense	probably damaging	1.00
R5183:Zfp618	UTSW	4	63,017,519 (GRCm39)	missense	probably benign
R5354:Zfp618	UTSW	4	62,998,265 (GRCm39)	missense	probably damaging	1.00
R5383:Zfp618	UTSW	4	63,013,729 (GRCm39)	missense	probably benign	0.33
R5774:Zfp618	UTSW	4	63,050,799 (GRCm39)	missense	probably damaging	1.00
R5932:Zfp618	UTSW	4	63,036,803 (GRCm39)	nonsense	probably null
R6101:Zfp618	UTSW	4	63,051,478 (GRCm39)	missense	probably benign	0.09
R6105:Zfp618	UTSW	4	63,051,478 (GRCm39)	missense	probably benign	0.09
R6478:Zfp618	UTSW	4	63,050,943 (GRCm39)	missense	probably damaging	1.00
R6598:Zfp618	UTSW	4	63,007,636 (GRCm39)	missense	probably damaging	1.00
R7386:Zfp618	UTSW	4	63,013,622 (GRCm39)	critical splice donor site	probably null
R7666:Zfp618	UTSW	4	63,050,954 (GRCm39)	nonsense	probably null
R7678:Zfp618	UTSW	4	63,004,858 (GRCm39)	missense	probably benign	0.07
R7975:Zfp618	UTSW	4	63,049,352 (GRCm39)	missense	possibly damaging	0.93
R8276:Zfp618	UTSW	4	63,051,193 (GRCm39)	missense	probably damaging	1.00
R8421:Zfp618	UTSW	4	63,051,483 (GRCm39)	missense	probably damaging	1.00
R8988:Zfp618	UTSW	4	63,012,708 (GRCm39)	missense	probably benign	0.09
R9022:Zfp618	UTSW	4	63,012,687 (GRCm39)	missense	probably damaging	1.00
R9150:Zfp618	UTSW	4	63,039,603 (GRCm39)	nonsense	probably null
R9163:Zfp618	UTSW	4	63,051,511 (GRCm39)	missense	probably damaging	1.00
R9364:Zfp618	UTSW	4	63,036,824 (GRCm39)	missense	probably damaging	0.99
R9382:Zfp618	UTSW	4	63,051,258 (GRCm39)	missense	probably damaging	0.97
R9424:Zfp618	UTSW	4	63,051,282 (GRCm39)	missense	probably benign	0.00
R9462:Zfp618	UTSW	4	63,051,510 (GRCm39)	missense	possibly damaging	0.94
R9576:Zfp618	UTSW	4	63,051,282 (GRCm39)	missense	probably benign	0.00
R9587:Zfp618	UTSW	4	63,051,916 (GRCm39)	missense
X0011:Zfp618	UTSW	4	62,998,243 (GRCm39)	missense	probably damaging	0.99
Z1176:Zfp618	UTSW	4	63,051,000 (GRCm39)	missense	probably benign	0.12
Z1176:Zfp618	UTSW	4	63,013,734 (GRCm39)	missense	probably benign	0.29

Posted On

2016-08-02