Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03261:Scart2'

414815

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scart2

Ensembl Gene

ENSMUSG00000054672

Gene Name

scavenger receptor family member expressed on T cells 2

Synonyms

5830411N06Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03261

Quality Score

Status

Chromosome

Chromosomal Location

139827197-139880649 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 139874746 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 408 (H408R)

Ref Sequence

ENSEMBL: ENSMUSP00000131905 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093984] [ENSMUST00000164583]

AlphaFold

B3F5L4

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000059882

SMART Domains

Protein: ENSMUSP00000061346
Gene: ENSMUSG00000054672

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
SR	29	130	1.49e-18	SMART
SR	137	233	2.53e-4	SMART
SR	238	336	1.65e-34	SMART
SR	340	440	4.53e-32	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000093984
AA Change: H292R

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000091520
Gene: ENSMUSG00000054672
AA Change: H292R

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
SR	29	130	1.49e-18	SMART
SR	137	233	2.53e-4	SMART
SR	238	336	1.65e-34	SMART
SR	340	440	4.53e-32	SMART
SR	446	546	8.78e-30	SMART
SR	551	651	1.26e-53	SMART
SR	656	756	2.88e-16	SMART
SR	783	883	7.62e-48	SMART
transmembrane domain	903	925	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000164583
AA Change: H408R

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000131905
Gene: ENSMUSG00000054672
AA Change: H408R

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
SR	29	130	1.49e-18	SMART
SR	137	233	2.53e-4	SMART
Blast:SR	291	349	5e-12	BLAST
SR	354	452	1.65e-34	SMART
SR	456	556	4.53e-32	SMART
SR	562	662	8.78e-30	SMART
SR	667	767	1.26e-53	SMART
SR	772	872	2.88e-16	SMART
SR	899	999	7.62e-48	SMART
transmembrane domain	1019	1041	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210212

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211749

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310022A10Rik	T	G	7: 27,279,863 (GRCm39)	Y281*	probably null	Het
Adamts3	T	C	5: 90,030,756 (GRCm39)		probably benign	Het
Afp	T	C	5: 90,639,610 (GRCm39)		probably null	Het
Ap1g2	T	C	14: 55,337,987 (GRCm39)	T634A	probably benign	Het
Cidec	A	G	6: 113,410,133 (GRCm39)	V32A	probably benign	Het
Dip2a	G	A	10: 76,140,982 (GRCm39)	P315S	possibly damaging	Het
Hoxc11	T	C	15: 102,863,178 (GRCm39)	V73A	probably benign	Het
Jmjd1c	A	G	10: 67,067,849 (GRCm39)	Y1784C	probably damaging	Het
Mmp21	A	G	7: 133,276,403 (GRCm39)	V480A	probably benign	Het
Nek4	C	T	14: 30,697,247 (GRCm39)	T471I	probably benign	Het
Nr4a2	A	G	2: 57,000,199 (GRCm39)	V299A	probably benign	Het
Or14j8	A	T	17: 38,263,697 (GRCm39)	S73T	possibly damaging	Het
Or6c5	A	G	10: 129,074,272 (GRCm39)	T85A	possibly damaging	Het
Ptprg	A	G	14: 12,225,552 (GRCm38)	D505G	probably damaging	Het
Rag2	A	G	2: 101,460,608 (GRCm39)	D306G	probably damaging	Het
Rpap2	T	A	5: 107,746,426 (GRCm39)	S38T	possibly damaging	Het
Scgb2b7	A	T	7: 31,404,506 (GRCm39)	C65S	probably damaging	Het
Slx4ip	A	T	2: 136,888,659 (GRCm39)	R113S	probably benign	Het
Smyd5	T	A	6: 85,409,000 (GRCm39)	M5K	probably benign	Het
Stkld1	A	T	2: 26,842,789 (GRCm39)	H587L	probably benign	Het
Taf4b	A	G	18: 14,954,585 (GRCm39)	T554A	probably benign	Het
Tex16	C	A	X: 111,028,552 (GRCm39)	D350E	possibly damaging	Het
Tex38	T	C	4: 115,637,723 (GRCm39)	K27E	possibly damaging	Het
Trdv4	T	C	14: 54,312,875 (GRCm39)	L83P	possibly damaging	Het
Ugt2a3	G	A	5: 87,484,439 (GRCm39)	P195L	probably damaging	Het
Vmn1r120	A	G	7: 20,787,450 (GRCm39)	L87P	probably damaging	Het
Zfp236	T	C	18: 82,648,733 (GRCm39)	D916G	possibly damaging	Het

Other mutations in Scart2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Scart2	APN	7	139,874,755 (GRCm39)	missense	probably damaging	0.99
IGL01101:Scart2	APN	7	139,876,017 (GRCm39)	missense	probably benign	0.35
IGL01120:Scart2	APN	7	139,876,472 (GRCm39)	missense	probably benign	0.02
IGL01958:Scart2	APN	7	139,854,040 (GRCm39)	missense	probably damaging	1.00
IGL02150:Scart2	APN	7	139,877,772 (GRCm39)	missense	possibly damaging	0.84
IGL02193:Scart2	APN	7	139,828,913 (GRCm39)	missense	probably benign	0.17
IGL02239:Scart2	APN	7	139,875,756 (GRCm39)	missense	probably damaging	1.00
IGL02335:Scart2	APN	7	139,876,453 (GRCm39)	missense	probably damaging	1.00
IGL02569:Scart2	APN	7	139,878,275 (GRCm39)	missense	probably benign	0.01
IGL02993:Scart2	APN	7	139,876,486 (GRCm39)	missense	probably benign	0.07
IGL03365:Scart2	APN	7	139,876,682 (GRCm39)	missense	probably damaging	1.00
IGL03399:Scart2	APN	7	139,827,869 (GRCm39)	missense	probably benign	0.00
IGL03052:Scart2	UTSW	7	139,828,827 (GRCm39)	missense	probably damaging	1.00
PIT4791001:Scart2	UTSW	7	139,853,975 (GRCm39)	missense	possibly damaging	0.53
R0021:Scart2	UTSW	7	139,876,310 (GRCm39)	missense	probably benign	0.15
R0021:Scart2	UTSW	7	139,876,310 (GRCm39)	missense	probably benign	0.15
R0347:Scart2	UTSW	7	139,877,767 (GRCm39)	missense	probably damaging	1.00
R0374:Scart2	UTSW	7	139,828,874 (GRCm39)	missense	probably damaging	1.00
R0639:Scart2	UTSW	7	139,827,872 (GRCm39)	missense	probably benign	0.01
R0667:Scart2	UTSW	7	139,841,450 (GRCm39)	missense	possibly damaging	0.73
R0789:Scart2	UTSW	7	139,828,133 (GRCm39)	missense	probably damaging	1.00
R0959:Scart2	UTSW	7	139,874,704 (GRCm39)	missense	probably damaging	1.00
R1316:Scart2	UTSW	7	139,879,583 (GRCm39)	missense	probably benign	0.09
R1764:Scart2	UTSW	7	139,877,178 (GRCm39)	missense	probably benign	0.00
R2247:Scart2	UTSW	7	139,829,042 (GRCm39)	missense	probably null	0.96
R2379:Scart2	UTSW	7	139,879,682 (GRCm39)	missense	probably benign	0.15
R4112:Scart2	UTSW	7	139,878,281 (GRCm39)	nonsense	probably null
R4114:Scart2	UTSW	7	139,877,823 (GRCm39)	missense	probably damaging	1.00
R4346:Scart2	UTSW	7	139,827,878 (GRCm39)	missense	probably damaging	0.97
R4836:Scart2	UTSW	7	139,879,021 (GRCm39)	missense	probably benign
R4956:Scart2	UTSW	7	139,878,275 (GRCm39)	missense	probably benign	0.00
R5208:Scart2	UTSW	7	139,877,949 (GRCm39)	missense	probably benign	0.00
R5571:Scart2	UTSW	7	139,829,036 (GRCm39)	missense	probably damaging	1.00
R5583:Scart2	UTSW	7	139,876,739 (GRCm39)	missense	probably damaging	1.00
R5645:Scart2	UTSW	7	139,828,853 (GRCm39)	missense	possibly damaging	0.95
R6183:Scart2	UTSW	7	139,875,947 (GRCm39)	missense	possibly damaging	0.82
R6995:Scart2	UTSW	7	139,841,514 (GRCm39)	missense	probably benign
R7436:Scart2	UTSW	7	139,841,520 (GRCm39)	missense	probably benign
R7621:Scart2	UTSW	7	139,876,742 (GRCm39)	missense	probably damaging	1.00
R7662:Scart2	UTSW	7	139,874,725 (GRCm39)	missense	possibly damaging	0.58
R7669:Scart2	UTSW	7	139,876,234 (GRCm39)	missense	possibly damaging	0.47
R7686:Scart2	UTSW	7	139,828,965 (GRCm39)	missense	probably benign	0.00
R7985:Scart2	UTSW	7	139,876,806 (GRCm39)	missense	probably damaging	1.00
R8330:Scart2	UTSW	7	139,876,231 (GRCm39)	nonsense	probably null
R8843:Scart2	UTSW	7	139,828,913 (GRCm39)	missense	possibly damaging	0.93
R8888:Scart2	UTSW	7	139,841,532 (GRCm39)	missense	possibly damaging	0.93
R8895:Scart2	UTSW	7	139,841,532 (GRCm39)	missense	possibly damaging	0.93
R9044:Scart2	UTSW	7	139,828,010 (GRCm39)	missense	probably damaging	1.00
R9142:Scart2	UTSW	7	139,877,806 (GRCm39)	missense	probably damaging	1.00
R9152:Scart2	UTSW	7	139,877,256 (GRCm39)	missense	possibly damaging	0.55
R9470:Scart2	UTSW	7	139,827,345 (GRCm39)	missense	probably benign	0.07
R9509:Scart2	UTSW	7	139,879,644 (GRCm39)	nonsense	probably null
R9522:Scart2	UTSW	7	139,853,987 (GRCm39)	missense	possibly damaging	0.73
R9755:Scart2	UTSW	7	139,841,544 (GRCm39)	critical splice donor site	probably null
R9794:Scart2	UTSW	7	139,874,716 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02