Incidental Mutation 'IGL03263:Bcas3'
ID414985
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Bcas3
Ensembl Gene ENSMUSG00000059439
Gene Namebreast carcinoma amplified sequence 3
Synonyms2610028P08Rik, 1500019F07Rik, rudhira, K20D4
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.730) question?
Stock #IGL03263
Quality Score
Status
Chromosome11
Chromosomal Location85353167-85826058 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) C to T at 85822122 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000074875] [ENSMUST00000092821] [ENSMUST00000092822] [ENSMUST00000108061] [ENSMUST00000108062]
Predicted Effect probably benign
Transcript: ENSMUST00000074875
SMART Domains Protein: ENSMUSP00000074416
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 3e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 792 2.3e-33 PFAM
low complexity region 885 901 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000092821
SMART Domains Protein: ENSMUSP00000090496
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 3e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 776 3.8e-35 PFAM
low complexity region 870 886 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000092822
SMART Domains Protein: ENSMUSP00000090497
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
low complexity region 3 17 N/A INTRINSIC
low complexity region 28 37 N/A INTRINSIC
Pfam:BCAS3 44 298 1.2e-35 PFAM
low complexity region 415 431 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108061
SMART Domains Protein: ENSMUSP00000103696
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 2e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 789 1e-33 PFAM
low complexity region 899 913 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108062
SMART Domains Protein: ENSMUSP00000103697
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
Blast:WD40 56 104 2e-17 BLAST
WD40 340 380 7.7e-1 SMART
WD40 390 433 2.47e1 SMART
low complexity region 480 494 N/A INTRINSIC
low complexity region 505 514 N/A INTRINSIC
Pfam:BCAS3 521 796 1.3e-28 PFAM
low complexity region 899 913 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130343
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136117
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140562
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140673
Predicted Effect probably benign
Transcript: ENSMUST00000142596
SMART Domains Protein: ENSMUSP00000122571
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
low complexity region 7 21 N/A INTRINSIC
low complexity region 32 41 N/A INTRINSIC
Pfam:BCAS3 48 323 3e-29 PFAM
low complexity region 434 450 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145281
Predicted Effect probably benign
Transcript: ENSMUST00000149662
SMART Domains Protein: ENSMUSP00000120891
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
low complexity region 41 52 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000154396
SMART Domains Protein: ENSMUSP00000122154
Gene: ENSMUSG00000059439

DomainStartEndE-ValueType
WD40 120 160 7.7e-1 SMART
WD40 170 213 2.47e1 SMART
low complexity region 260 274 N/A INTRINSIC
low complexity region 285 294 N/A INTRINSIC
Pfam:BCAS3 301 561 1e-30 PFAM
low complexity region 650 666 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik T A 5: 138,564,237 I81F probably damaging Het
Acacb C T 5: 114,213,693 H1164Y probably damaging Het
Adamts5 A T 16: 85,869,942 V554E probably damaging Het
Asns G A 6: 7,689,404 R33C probably benign Het
BC051076 T G 5: 87,964,118 noncoding transcript Het
Bpifb1 A G 2: 154,215,306 M395V probably benign Het
Cdcp1 C A 9: 123,180,087 V509L probably benign Het
Cdhr2 A G 13: 54,718,113 T277A possibly damaging Het
Ces1d C A 8: 93,169,718 probably null Het
Clca4a T A 3: 144,966,431 E250V probably damaging Het
Cplx4 T C 18: 65,967,488 D79G probably benign Het
Dcaf11 A G 14: 55,565,492 D246G probably damaging Het
Dnah2 A T 11: 69,529,381 probably null Het
Dock3 A T 9: 106,930,131 probably benign Het
Fam170a T C 18: 50,280,521 probably benign Het
Fgfr2 T A 7: 130,180,419 M423L probably benign Het
Gabra2 A G 5: 70,973,493 F331L probably damaging Het
Galnt18 C T 7: 111,520,114 R400Q probably damaging Het
Gm884 A G 11: 103,613,699 V2481A possibly damaging Het
H2-M11 A T 17: 36,548,913 Q266L probably damaging Het
Igf2bp1 A T 11: 95,966,673 V502D probably damaging Het
Ik A G 18: 36,748,646 N111S probably damaging Het
Intu T A 3: 40,672,597 Y269* probably null Het
Krt82 T C 15: 101,541,872 Y463C probably benign Het
Lrig1 A G 6: 94,611,647 M507T probably benign Het
Mag T G 7: 30,899,528 probably null Het
Map7 T A 10: 20,245,322 Y121* probably null Het
March6 A G 15: 31,486,362 I349T probably benign Het
Mas1 A G 17: 12,841,564 V324A possibly damaging Het
Nckap1l T C 15: 103,464,405 W259R probably damaging Het
Nhsl1 T A 10: 18,498,079 Y164* probably null Het
Olfr678 T A 7: 105,070,002 H178Q probably damaging Het
Olfr885 A T 9: 38,061,713 Y131F probably damaging Het
Pcdhb2 A G 18: 37,296,006 D344G probably damaging Het
Pclo T C 5: 14,681,810 V3442A unknown Het
Polr3c C T 3: 96,714,251 probably benign Het
Ppp2r2d C T 7: 138,872,922 R11* probably null Het
Ptgfr T A 3: 151,835,863 M3L probably benign Het
Rfx6 A G 10: 51,725,807 S741G probably benign Het
Rif1 T C 2: 52,090,261 V490A probably damaging Het
Samd7 T A 3: 30,762,153 H349Q probably damaging Het
Sh3pxd2a T C 19: 47,314,043 N199S probably damaging Het
Spef2 T A 15: 9,667,219 K794N possibly damaging Het
Spta1 C T 1: 174,213,918 A1316V probably damaging Het
Vwa7 A G 17: 35,021,599 E410G probably benign Het
Washc2 T A 6: 116,238,123 probably benign Het
Wdr72 A C 9: 74,157,429 Y581S probably damaging Het
Zdhhc17 T C 10: 110,961,016 D298G probably damaging Het
Other mutations in Bcas3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Bcas3 APN 11 85365591 missense probably damaging 0.98
IGL00754:Bcas3 APN 11 85495823 splice site probably benign
IGL01712:Bcas3 APN 11 85581048 missense probably damaging 0.99
IGL02073:Bcas3 APN 11 85557437 missense probably damaging 1.00
IGL02261:Bcas3 APN 11 85531930 missense probably damaging 1.00
IGL02323:Bcas3 APN 11 85495845 missense probably damaging 0.97
IGL02493:Bcas3 APN 11 85495882 missense probably damaging 0.99
IGL02609:Bcas3 APN 11 85457894 missense probably damaging 1.00
IGL02808:Bcas3 APN 11 85495851 missense probably benign 0.02
IGL03085:Bcas3 APN 11 85476783 missense probably damaging 1.00
FR4340:Bcas3 UTSW 11 85509497 missense probably benign 0.12
FR4342:Bcas3 UTSW 11 85509497 missense probably benign 0.12
FR4589:Bcas3 UTSW 11 85509497 missense probably benign 0.12
IGL02991:Bcas3 UTSW 11 85457887 nonsense probably null
PIT4377001:Bcas3 UTSW 11 85495842 missense probably damaging 0.98
PIT4472001:Bcas3 UTSW 11 85531900 missense probably damaging 0.99
R0145:Bcas3 UTSW 11 85359610 splice site probably benign
R0257:Bcas3 UTSW 11 85822039 missense probably benign 0.00
R0276:Bcas3 UTSW 11 85470837 critical splice donor site probably null
R0485:Bcas3 UTSW 11 85495850 missense probably damaging 0.99
R1053:Bcas3 UTSW 11 85557410 missense probably benign 0.10
R1833:Bcas3 UTSW 11 85583949 missense probably benign 0.00
R2107:Bcas3 UTSW 11 85457878 missense probably damaging 0.97
R2108:Bcas3 UTSW 11 85457878 missense probably damaging 0.97
R2215:Bcas3 UTSW 11 85801943 missense probably damaging 0.99
R2404:Bcas3 UTSW 11 85354889 splice site probably benign
R2413:Bcas3 UTSW 11 85531855 missense probably damaging 1.00
R3694:Bcas3 UTSW 11 85801802 missense probably benign 0.00
R3880:Bcas3 UTSW 11 85371122 missense probably benign 0.02
R4241:Bcas3 UTSW 11 85470826 missense probably damaging 0.99
R4794:Bcas3 UTSW 11 85509468 missense probably damaging 1.00
R5035:Bcas3 UTSW 11 85543945 missense probably damaging 1.00
R5073:Bcas3 UTSW 11 85371132 missense probably damaging 1.00
R5245:Bcas3 UTSW 11 85559086 missense probably damaging 1.00
R5358:Bcas3 UTSW 11 85451755 missense probably benign 0.02
R5395:Bcas3 UTSW 11 85825249 missense probably damaging 0.99
R5615:Bcas3 UTSW 11 85470761 missense probably damaging 1.00
R5753:Bcas3 UTSW 11 85822084 intron probably benign
R6198:Bcas3 UTSW 11 85509435 missense probably damaging 0.99
R6668:Bcas3 UTSW 11 85801851 missense probably damaging 0.98
R7170:Bcas3 UTSW 11 85495918 missense probably damaging 0.96
R7171:Bcas3 UTSW 11 85583937 missense probably damaging 1.00
V3553:Bcas3 UTSW 11 85822100 intron probably benign
X0020:Bcas3 UTSW 11 85531808 missense possibly damaging 0.95
Posted On2016-08-02