Incidental Mutation 'IGL03269:Tcrg-V4'
ID415202
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tcrg-V4
Ensembl Gene ENSMUSG00000076745
Gene NameT cell receptor gamma, variable 4
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL03269
Quality Score
Status
Chromosome13
Chromosomal Location19184981-19185501 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 19185452 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Lysine at position 122 (I122K)
Ref Sequence ENSEMBL: ENSMUSP00000100335 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103554] [ENSMUST00000103555] [ENSMUST00000198330]
Predicted Effect probably damaging
Transcript: ENSMUST00000103554
AA Change: I122K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100335
Gene: ENSMUSG00000076745
AA Change: I122K

DomainStartEndE-ValueType
IGv 57 137 5.79e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103555
SMART Domains Protein: ENSMUSP00000100336
Gene: ENSMUSG00000076746

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 40 134 2.94e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197661
Predicted Effect probably benign
Transcript: ENSMUST00000198330
SMART Domains Protein: ENSMUSP00000142811
Gene: ENSMUSG00000076746

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IG 27 121 1.2e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl2 T A 2: 27,108,355 C930* probably null Het
Ankar A T 1: 72,665,201 V854E probably damaging Het
Ccdc151 A G 9: 21,998,043 probably null Het
Ceacam3 T A 7: 17,161,842 L579Q probably damaging Het
Clip2 G T 5: 134,516,894 H314Q probably damaging Het
Fbxo28 A G 1: 182,317,018 V327A possibly damaging Het
Gdap1 T A 1: 17,161,505 F358Y probably benign Het
Ighv1-18 T C 12: 114,682,846 Y46C probably damaging Het
Il1rl2 T A 1: 40,365,312 F531Y probably damaging Het
Irf6 A G 1: 193,162,598 probably benign Het
Ncoa6 T C 2: 155,406,489 T1632A probably damaging Het
Olfr1469 T A 19: 13,411,428 N286K probably damaging Het
Olfr723 T A 14: 49,928,708 T279S probably damaging Het
Olfr902 A G 9: 38,448,901 T10A probably benign Het
Osgepl1 C A 1: 53,321,112 Y332* probably null Het
Pibf1 G A 14: 99,187,735 A553T probably damaging Het
Prpf38b A G 3: 108,905,241 F219L probably benign Het
Pwp1 C A 10: 85,882,904 Q312K probably damaging Het
Rnf17 T C 14: 56,427,946 V185A possibly damaging Het
Serpina3k T C 12: 104,340,521 I4T possibly damaging Het
Slc33a1 A G 3: 63,963,757 V145A probably damaging Het
Slco3a1 T C 7: 74,318,532 D480G possibly damaging Het
Tdpoz4 G A 3: 93,796,837 C147Y probably damaging Het
Tlr4 C A 4: 66,840,796 P609T probably damaging Het
Ttc30a2 T C 2: 75,978,135 D11G possibly damaging Het
Unc79 A G 12: 103,088,677 K927E probably damaging Het
Vmn1r71 G A 7: 10,748,644 T39I possibly damaging Het
Vmn2r9 A G 5: 108,847,954 L276P probably damaging Het
Zfp335 C A 2: 164,900,354 R570L probably damaging Het
Other mutations in Tcrg-V4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Tcrg-V4 APN 13 19185508 unclassified probably benign
IGL02821:Tcrg-V4 APN 13 19185252 missense possibly damaging 0.60
R0102:Tcrg-V4 UTSW 13 19185200 missense possibly damaging 0.74
R0104:Tcrg-V4 UTSW 13 19185310 missense probably damaging 1.00
R4369:Tcrg-V4 UTSW 13 19185397 missense probably benign 0.06
R4856:Tcrg-V4 UTSW 13 19185066 missense probably benign 0.01
R4886:Tcrg-V4 UTSW 13 19185066 missense probably benign 0.01
R6575:Tcrg-V4 UTSW 13 19185080 missense probably benign 0.03
Posted On2016-08-02